Results 41 to 50 of about 964,892 (304)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Acta Physica Sinica, 1953 This paper consists of two parts. The first part gives a description of the motion of large eddies in a turbulent flow. The non-stationary character of the large eddies is emphasized. Up to present, there appears to be some confusion regarding the law of turbulence decay, especially the variation of the microscale with time. This paper introduces a new
openaire +3 more sources
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Natural Image Decay With a Decay Effects Generator
IEEE Access, 2023 We present a novel framework for simulating time-varying decay effects for natural images. Conventional methods assume the input image includes enough decay information and uses the color or texture information of the decayed regions to transfer its effect to the non-decayed regions.
Guoqing Hao +4 more
openaire +2 more sources
Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers
FEBS Letters, EarlyView.Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui +4 more
wiley +1 more source
HeritageThis study investigates the deterioration of granite graffiti at the Philae Archaeological Site on Bigeh Island (Aswan, Egypt), attributed to Khaemwaset (1281–1225 BCE, 19th Dynasty).
Abdelrhman Fahmy +2 more
doaj +1 more source
Materiales de Construccion, 2020 The advanced condition of deterioration of the column’s bases of the courtyard of the Bishop’s Palace of Tarazona (Spain) built in the middle of 16th century required its restoration with Aragonese alabaster.
R. Bustamante +3 more
doaj +1 more source
FEBS Letters, EarlyView.Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana +3 more
wiley +1 more source