Results 151 to 160 of about 15,112 (276)

Engineered extracellular vesicles for precision renal therapy: Bioengineering strategies and clinical translation

Interdisciplinary Medicine, EarlyView.
Engineered extracellular vesicles (EVs) offer a versatile platform for kidney‐targeted therapy. This review summarizes bioengineering strategies, including cargo loading, surface modification, biomimetic fabrication, and biomaterial integration. We highlight translational challenges and propose future solutions to accelerate the clinical application of
Linru Shi, Bei Li, Wanzhu Liu, Haifeng Wu, Wenrong Xu, Cheng Ji, Hui Qian   +6 more
wiley   +1 more source

The effect of bioactive membrane in alveolar ridge preservation: A double‐blind randomized clinical trial

Journal of Periodontology, EarlyView.
Abstract Background This randomized controlled trial aims to evaluate alveolar ridge preservation (ARP) with or without a biologically active amnion–chorion membrane (BACM). Methods Thirty patients requiring tooth extraction in the esthetic zone were randomly assigned to 2 groups.
Magdalena Orlowska, Muhammad H. A. Saleh, Ann Decker, Junying Li, Alice Ou, Nataly Zambrana, Paolo Nava, Fernanda A. da Costa Deller, Hom‐Lay Wang   +8 more
wiley   +1 more source

Crosslinked Gelatin‐Polycaprolactone Scaffolds: Balancing Biocompatibility and Inflammatory Response for Tissue Engineering Applications

Polymer Engineering &Science, EarlyView.
Crosslinked gelatin‐functionalized PCL scaffolds exhibited enhanced hydrophilicity, structural stability, and porous interactions. In vitro assays demonstrated improved osteoblast adhesion, viability, and proliferation without cytotoxicity, while in vivo evaluation showed no adverse inflammatory response, supporting their potential application in ...
Fernanda Ramírez‐Ruiz, Israel Núñez‐Tapia, Lucía Pérez‐Sánchez, María Cristina Piña‐Barba, Irving Sanchez‐Leal, Marco Antonio Alvarez‐Perez, Iriczalli Cruz‐Maya, Janeth Serrano‐Bello   +7 more
wiley   +1 more source

Migrasomes, Matrix‐Bound Nanovesicles, and More: Messengers in the Matrix

PROTEOMICS, EarlyView.
ABSTRACT Extracellular vesicles (EVs) and particles (EPs) are diverse micro‐ and nanoparticles that circulate in bodily fluids and can attach to, or be deposited onto, the extracellular matrix (ECM) and other surfaces. To date, the nomenclature and classification of matrix‐bound or matrix‐associated EVs and EPs (MEVPs) have been unclear, largely due to
Anna V. Kolesov, Natalie Reitz, Marley Dewey, Colin L. Hisey   +3 more
wiley   +1 more source

ChitoSilkBioPatch: A bio‐inspired wound dressing scaffold for antibiotic‐free diabetic wound management

VIEW, EarlyView.
We present ChitoSilkBioPatch, a maleimide‐functionalized chitosan/dACM hydrogel integrated with a stretchable nanopatterned silk mesh to provide intrinsic, antibiotic‐free antibacterial activity and bioactive wound support. The scaffold eliminates S. aureus and P.
Dorsa Dehghan‐Baniani, Babak Mehrjou, Yucong Li, Zhaowei Jiang, Xiaomin Lu, Yin Xiao, Huanxiong Chen, Tsz Lam Yiu, Chi Chiu Wang, Hongkai Wu, Gang Li, Paul K. Chu, Wayne Yuk Wai Lee   +12 more
wiley   +1 more source

Comparative Outcomes of Two Non‐Crosslinked Porcine Acellular Dermal Matrices in Complex Abdominal Wall Reconstruction: A Randomized Controlled Trial and an Observational Cohort Study

World Journal of Surgery, EarlyView.
Biologic mesh has historically been used for ventral hernia repairs (VHR) in contaminated fields in an off‐label fashion due to early evidence suggesting that they may be able to withstand these conditions more favorably than synthetic mesh. This study aims to compare outcomes of two non‐crosslinked porcine acellular dermal matrices—XenMatrix (Bard ...
Abdulaziz Elemosho, Benjamin A. Sarac, Molly A. Olson, Ibrahim Khansa, Paige N. Hackenberger, Vimal Narula, Daniel S. Eiferman, Jeffrey E. Janis   +7 more
wiley   +1 more source

In Vitro and In Vivo Evaluation of Decellularized Porcine Femoral Aorta Reinforced With Electrospun Coarse Polycaprolactone Fibers for Vascular Graft Application

Artificial Organs, EarlyView.
This study aims to develop a hybrid small‐diameter vascular graft by combining electrospun PCL with decellularized porcine femoral aorta (PECM). The graft showed complete decellularization, strong mechanical integrity, and no layer delamination.
Hyun‐Yong Lee, Md. Abdullah Al Fahad, Myeongki Park, Hoe‐Jin Kang, Nusrat Jahan, Prayas Chakma Shanto, Hyeyoung Kim, Byong‐Taek Lee, Sang Ho Bae   +8 more
wiley   +1 more source

Degradomics for large‐scale mechanistic insights on proteases and proteolysis in human health

The FEBS Journal, EarlyView.
Proteolysis has an important role in human disease but remains relatively unexplored. Degradomics, the uncovering of proteolysis in tissues, cells, and proteins, uses mass spectrometry‐based terminomics to identify protein termini occurring therein (forward degradomics) and to define the actions of proteases (reverse degradomics).
Daniel R. Martin, Sumit Bhutada, Suneel S. Apte   +2 more
wiley   +1 more source

Slow‐Resorbing Small Intestinal Submucosa Membrane for Horizontal Ridge Augmentation: A Case Series

Journal of Esthetic and Restorative Dentistry, EarlyView.
ABSTRACT Objective To evaluate the efficacy of a slow‐resorbing small intestinal submucosa (SIS) membrane combined with freeze‐dried bone allograft (FDBA) for horizontal bone augmentation in severely atrophic ridges. Materials and Methods Six patients underwent horizontal ridge augmentation using FDBA and a slow‐resorbing SIS membrane.
Mingxu Sun, Zhaozhao Chen, Zhen Yang, Chongxia Yue, Xingwang Liu, Hom‐Lay Wang   +5 more
wiley   +1 more source

Cell Therapy for Periodontal, Soft‐Tissue, and Craniofacial Regeneration

Journal of Periodontal Research, EarlyView.
The clinical translation of mesenchymal stem/stromal cells (MSCs) represents a major advancement in dentistry, especially for periodontal, soft‐tissue, and craniofacial regeneration. However, several challenges remain to be addressed, including the absence of standardised protocols, limited scalability, regulatory hurdles, a lack of well‐controlled ...
Kamal Mustafa, Shuntaro Yamada, Nerea Sanchez, Magdalena Mayol, Cecilie Gjerde, Mariano Sanz   +5 more
wiley   +1 more source