Two Decades of Advances and Limitations in Organ Recellularization [PDF]
Current Issues in Molecular BiologyThe recellularization of tissues after decellularization is a relatively new technology in the field of tissue engineering (TE). Decellularization involves removing cells from a tissue or organ, leaving only the extracellular matrix (ECM).
Alina Stoian +2 more
exaly +4 more sources
Effective Recellularization Using Mesenchymal Stem Cell Monoculture for Next-Generation Heart Valves [PDF]
BioengineeringObjective: Effectively eliminating xenoimmunogenicity and achieving recellularization in cardiac xenografts remains a critical challenge in developing an ideal implantable xenograft.
So Young Kim +7 more
doaj +2 more sources
Recellularization of Bioengineered Scaffolds for Vascular Composite Allotransplantation
Frontiers in Surgery, 2022 Traumatic injuries or cancer resection resulting in large volumetric soft tissue loss requires surgical reconstruction. Vascular composite allotransplantation (VCA) is an emerging reconstructive option that transfers multiple, complex tissues as a whole ...
Siba Haykal, Haykal Siba
exaly +3 more sources
Biological tissue engineering for Fontan failure using decellularized extracellular matrix: a systematic review [PDF]
Journal of Translational MedicineBackground Functional univentricular heart disease is the most severe congenital condition, managed by Fontan surgery, which is life-sustaining by creating a non-contractile conduit yet limited by long-term complications.
Elizaveta Polyakova +11 more
doaj +2 more sources
Enhanced recellularization by using albumin coating with roller bottle cell culture
Regenerative Therapy, 2023 Introduction: The decellularization and recellularization is a promising approach for tissue engineering and regenerative medicine. However, the decellularization process depletes important components like glycosaminoglycans (GAGs), affecting cell ...
Boyun Kim, Jina Ryu
exaly +3 more sources
Ex vivo perfusion recellularization of acellular rat hindlimbs for vascular composite allotransplantation [PDF]
Scientific ReportsVascular composite allotransplantation (VCA) is a promising reconstructive surgical option for severe tissue loss. Autologous reconstructive methods are limited by donor tissue availability and donor site morbidity.
Aisha Adil +4 more
doaj +2 more sources
Recellularization of Native Tissue Derived Acellular Scaffolds with Mesenchymal Stem Cells
Cells, 2021 The functionalization of decellularized scaffolds is still challenging because of the recellularization-related limitations, including the finding of the most optimal kind of cell(s) and the best way to control their distribution within the scaffolds to ...
Ebtehal Ahmed +2 more
exaly +3 more sources
Recellularization of decellularized heart valves: Progress toward the tissue-engineered heart valve
Journal of Tissue Engineering, 2017 The tissue-engineered heart valve portends a new era in the field of valve replacement. Decellularized heart valves are of great interest as a scaffold for the tissue-engineered heart valve due to their naturally bioactive composition, clinical relevance
Mitchell C Vedepo +2 more
exaly +2 more sources
Cells, 2021 Background. Liver transplantation remains the only viable therapy for liver failure but has a severely restricted utility. Here, we aimed to decellularize rat livers to form acellular 3D bio-scaffolds suitable for seeding with induced pluripotent cells ...
Omnia A M Badr +2 more
exaly +3 more sources
A novel agarose-free, standardized generation and versatile ECM characterization of decellularized scaffolds from normal and fibrotic human lung tissue [PDF]
Frontiers in Bioengineering and BiotechnologyBackgroundThe extracellular matrix (ECM) is a key regulator of tissue homeostasis and remodeling in interstitial lung diseases (ILD) such as idiopathic pulmonary fibrosis (IPF) and fibrotic hypersensitivity pneumonitis (FHP).
Eike B. Preuß +17 more
doaj +2 more sources