Results 251 to 260 of about 15,112 (276)

Decellularized human valve allografts

The Annals of Thoracic Surgery, 2001
Variable performance of allograft tissues in children and some adults may be linked to an immune response and could be mitigated by reducing implant antigenicity.As endothelial and fibroblast cells are the likely source of valve antigenicity, human (CryoValve SG) and sheep pulmonary valves were decellularized using the SynerGraft treatment process ...
R C, Elkins, P E, Dawson, S, Goldstein, S P, Walsh, K S, Black   +4 more
openaire   +2 more sources

Alveolar Rhabdomyosarcoma Decellularization

2017
In cancer research, it is an urgent need in the obtainment of a simple and reproducible model that mimics in all the complexity the pathological microenvironment. Specifically, the will to improve the overall survival of young patients affected by rhabdomyosarcoma compels researchers to develop new models resembling the multifaceted environment of the ...
Pozzobon, Michela, Saggioro, Mattia, D'AGOSTINO, STEFANIA, Bisogno, Gianni, Muraca, Maurizio, Gamba, Piergiorgio   +5 more
openaire   +3 more sources

Biomedical Application of Decellularized Scaffolds

ACS Applied Bio Materials, 2023
Tissue loss and end-stage organ failure are serious health problems across the world. Natural and synthetic polymer scaffold material based artificial organs play an important role in the field of tissue engineering and organ regeneration, but they are not from the body and may cause side effects such as rejection.
Fang Zhang, Huimin Gao, Xuefeng Jiang, Fang Yang, Jun Zhang, Saijie Song, Jian Shen   +6 more
openaire   +2 more sources

Mouse Skeletal Muscle Decellularization

2017
Natural acellular matrices obtained from decellularization procedures are biocompatible and non-immunogenic materials considered promising tools for regenerative medicine purposes. Before in vivo implantation, these matrices must be efficiently decellularized, removing all the cellular components to avoid any immunogenic reaction.
Piccoli, Martina, Trevisan, Caterina, Maghin, Edoardo, Franzin, Chiara, Pozzobon, Michela, TREVISAN CATERINA   +5 more
openaire   +2 more sources

Corneal extracellular matrix decellularization

2020
Decellularized corneal scaffolds have the potential to be used as alternatives to donor corneas during keratoplasty. Here a decellularization technique is described that involves the use of sodium dodecyl sulfate, Triton-X100, DNAse and RNAse to remove cells and cellular constituents.
openaire   +2 more sources

Tracheal Cartilage Isolation and Decellularization

2017
Tissue decellularization allows isolation of tissue extracellular matrix components, enabling bioengineering of native tissue microenvironments with minimal antigenic components. Here we describe a method to harvest decellularized cartilage tissue from donor trachea using a series of chemical and enzymatic washes and incorporating the extracellular ...
Zachary, Galliger, Angela, Panoskaltsis-Mortari   +1 more
openaire   +2 more sources

Decellularization of organs and tissues

Khirurgiya. Zhurnal im. N.I. Pirogova, 2019
The use of allogenic materials in reconstructive surgery is of great scientific interest due to high availability of donor tissues. The positive aspects of allogenous tissue transplantation are complicated by the histological incompatibility of donor tissue and recipient organism.
O I, Startseva, M E, Sinelnikov, Yu V, Babayeva, V V, Trushenkova   +3 more
openaire   +2 more sources

Decellularization of Small Intestinal Submucosa

2021
Small intestinal submucosa (SIS) is the most studied extracellular matrix (ECM) for repair and regeneration of different organs and tissues. Promising results of SIS-ECM as a vascular graft, led scientists to examine its applicability for repairing other tissues.
Sahar, Jelodari, Esmaeil, Sadroddiny
openaire   +2 more sources

Decellularized matrices in regenerative medicine

Acta Biomaterialia, 2018
Of all biologic matrices, decellularized extracellular matrix (dECM) has emerged as a promising tool used either alone or when combined with other biologics in the fields of tissue engineering or regenerative medicine - both preclinically and clinically.
Doris A, Taylor, Luiz C, Sampaio, Zannatul, Ferdous, Andrea S, Gobin, Lakeshia J, Taite   +4 more
openaire   +2 more sources

Perfusion decellularization of whole organs

Nature Protocols, 2014
The native extracellular matrix (ECM) outlines the architecture of organs and tissues. It provides a unique niche of composition and form, which serves as a foundational scaffold that supports organ-specific cell types and enables normal organ function.
Jacques P, Guyette, Sarah E, Gilpin, Jonathan M, Charest, Luis F, Tapias, Xi, Ren, Harald C, Ott   +5 more
openaire   +2 more sources