Results 11 to 20 of about 74 (54)

Optogenetic methods to stimulate gamma motor neuron axons ex vivo

Experimental Physiology, EarlyView.
Abstract It is challenging to stimulate gamma motor neurons, which are important regulators of muscle spindle afferent function, without also recruiting alpha motor neurons. Here, we test the feasibility of stimulating gamma motor neuron axons using optogenetics in two transgenic mouse lines. We used an ex vivo muscle–nerve preparation in adult mice to
Apoorva Karekal, Remie Mandawe, Cameron Chun, Sai Kiran Byri, Danitza Cheline, Serena Ortiz, Shawn Hochman, Katherine A. Wilkinson   +7 more
wiley   +1 more source

Inhibition and potentiation of the exercise pressor reflex by pharmacological modulation of TRPC6 in male rats

The Journal of Physiology, EarlyView.
Abstract figure legend The majority of L4–L5 dorsal root ganglion cells innervating the triceps surae muscles of healthy rats expressed TRPC6 channels. In decerebrated rats, pharmacological inhibition of TRPC6 channels by injection of antagonists (SAR7334 or BI‐749327) into the arterial supply of the triceps surae muscles inhibited the exercise pressor
Guillaume P. Ducrocq, Laura Anselmi, Salvatore L. Stella Jr, Steven W. Copp, Victor Ruiz‐Velasco, Marc P. Kaufman   +5 more
wiley   +1 more source

Lactate and hydrogen ions play a predominant role in evoking the exercise pressor reflex during ischaemic contractions but not during freely perfused contractions

The Journal of Physiology, EarlyView.
Abstract figure legend The role of lactate and hydrogen ions in evoking the metabolic component of the exercise pressor reflex was studied in rats with either a functional pygm gene (pygm+/+) or with a non‐functional “knocked out” pygm gene (pygm−/−). The pygm gene is responsible for producing the myophosphorylase enzyme which catalyses the breakdown ...
Guillaume P. Ducrocq, Laura Anselmi, Victor Ruiz‐Velasco, Marc P. Kaufman   +3 more
wiley   +1 more source

Intracerebroventricular insulin injection acutely normalizes the augmented exercise pressor reflex in male rats with type 2 diabetes mellitus

The Journal of Physiology, EarlyView.
Abstract figure legend The exercise pressor reflex (EPR), evoked by muscle contraction, is exaggerated in male rats with type 2 diabetes mellitus (T2DM). Cerebrospinal fluid insulin and phosphoinositide 3‐kinase in the nucleus tractus solitarius levels are normal in controls and low in T2DM rats, corresponding with normal and exaggerated EPR function ...
Juan A. Estrada, Rie Ishizawa, Han‐Kyul Kim, Ayumi Fukazawa, Amane Hori, Norio Hotta, Gary A. Iwamoto, Scott A. Smith, Wanpen Vongpatanasin, Masaki Mizuno   +9 more
wiley   +1 more source

Craniotomia descompressiva no edema cerebral grave: a propósito de 30 casos operados Descompressive craniotomy in acute brain edema: report of 30 cases

Arquivos de Neuro-Psiquiatria, 1976
Craniotomia descompressiva uni ou bilateral foi empregada como tratamento paliativo em 30 casos de edema cerebral grave de etiologia predominantemente traumática. Coma, midríase e descerebração caracterizaram o quadro clínico na maioria dos casos.
José A. Gonçalves da Silva, Cláudio E. Gonçalves da Silva, Maricélia B. Rodrigues Sousa   +2 more
doaj  

There Are No Differences in Startle Conditioned Cervicomedullary Motor Evoked Potentials Across Isometric, Concentric, and Eccentric Muscle Actions at the Same Absolute Force Output

European Journal of Neuroscience, Volume 62, Issue 3, August 2025.
In this work we demonstrate for the first time that reticulospinal tract (RST) excitability can be indirectly measured using conditioned cervicomedullary motor evoked potentials (CMEPs) during dynamic muscle actions. Although there were no differences in RST excitability across isometric, concentric and eccentric muscle actions during the same absolute
Eoin Haigney, Elliott Atkinson, Paul Ansdell, Rodrigo Vitorio, Kevin Thomas, Stuart Goodall, Glyn Howatson, Luca Angius, Dawson J. Kidgell, Padraig Spillane, Emma Squires, Justin W. Andrushko   +11 more
wiley   +1 more source

Muscle afferent ASIC3 upregulation mediates the exacerbated exercise pressor reflex in male rats following hindlimb ischemia–reperfusion

Physiological Reports, Volume 13, Issue 13, July 2025.
Muscle Afferent ASIC3 Upregulation Mediates the Exacerbated Exercise Pressor Reflex in Male Rats Following Hindlimb Ischemia‐Reperfusion. Abstract We examined if the hindlimb muscle ischemia–reperfusion (IR) alters ASIC3‐mediated muscle afferent activity in regulating the exercise pressor reflex (EPR).
Lu Qin, Xuexin Zhang, Jianhua Li
wiley   +1 more source

Pervasive Motor and Balance Difficulties in University Students With Dyslexia

Dyslexia, Volume 31, Issue 2, May 2025.
ABSTRACT Previous research suggests that dyslexic university students are unlikely to experience significant co‐occurring motor or balance difficulties and may represent instances of ‘pure’ dyslexia. However, the motor and balance measures used in previous studies have been limited in scope.
Martin McPhillips, Helen McNally, Bronagh Taylor, Michail Doumas   +3 more
wiley   +1 more source

Bromethalin Exposure in Dogs and Cats: A 14‐Year Retrospective Study (2010–2023) From the California Animal Health and Food Safety Laboratory System

Journal of Veterinary Internal Medicine, Volume 39, Issue 3, May/June 2025.
ABSTRACT Background Bromethalin, a rodenticide, is increasingly used due to restrictions on other rodenticides. Objectives The study aimed to analyze the frequency, demographics, clinical signs, and diagnostics of suspected bromethalin intoxication in dogs and cats.
Sigal Klainbart, Marcos Pérez‐López, Michael S. Filigenzi, Robert H. Poppenga   +3 more
wiley   +1 more source

Mechanisms mediating muscle metaboreflex control of cardiac output during exercise: Impaired regulation in heart failure

Experimental Physiology, Volume 110, Issue 5, Page 675-685, 1 May 2025.
Abstract The ability to increase cardiac output during dynamic exercise is paramount for the ability to maintain workload performance. Reflex control of the cardiovascular system during exercise is complex and multifaceted involving multiple feedforward and feedback systems.
Donal S. O'Leary, Joseph Mannozzi
wiley   +1 more source