Results 21 to 30 of about 74 (54)
Intrinsic properties of spinal motoneurons degrade ankle torque control in humans
The Journal of Physiology, Volume 603, Issue 8, Page 2443-2463, 15 April 2025.Abstract figure legend All motor commands are processed via spinal motoneurons, whose intrinsic electrical properties are adapted by brainstem neuromodulatory inputs. The effects of these neuromodulatory inputs (i.e. persistent inward currents; PICs) must be precisely regulated by inhibitory mechanisms to support the full range of human motor ...
James A. Beauchamp +5 more
wiley +1 more source
Dendritic alterations precede age‐related dysphagia and nucleus ambiguus motor neuron death
The Journal of Physiology, Volume 603, Issue 5, Page 1299-1321, 1 March 2025.Abstract figure legend Here, we evaluate the effects of ageing on the timing and pressure generation during naturalistic water bolus swallows, using Millar catheters placed in the pharynx (purple: to measure swallow pressure) and in the thorax (green: to time the breath).
Matthew J. Fogarty
wiley +1 more source
Cancer, Volume 131, Issue 3, 1 February 2025.Abstract Tarlatamab is a bispecific T‐cell engager immunotherapy targeting delta‐like ligand 3 (DLL3) and the cluster of differentiation 3 (CD3) molecule. In the phase 2 DeLLphi‐301 trial of tarlatamab for patients with previously treated small cell lung cancer, tarlatamab 10 mg every 2 weeks achieved durable responses and encouraging survival outcomes.
Jacob M. Sands +18 more
wiley +1 more source
Role of forelimb morphology in muscle sensorimotor functions during locomotion in the cat
The Journal of Physiology, Volume 603, Issue 2, Page 447-487, 15 January 2025.Abstract figure legend Experimentally obtained and computed neuromechanical variables characterizing sensorimotor functions of cat forelimb muscles during locomotion. Abstract Previous studies established strong links between morphological characteristics of mammalian hindlimb muscles and their sensorimotor functions during locomotion.
Seyed Mohammadali Rahmati +9 more
wiley +1 more source
Are we there yet? CAR‐T therapy in multiple myeloma
British Journal of Haematology, Volume 205, Issue 6, Page 2175-2189, December 2024.Chimeric antigen receptor T‐cell (CAR‐T) therapy has achieved hitherto unseen responses in heavily pretreated relapsed/refractory multiple myeloma. Nevertheless, patients still relapse. Mechanisms of resistance to CAR‐T include tumour‐intrinsic factors, the immunosuppressive tumour microenvironment, impaired baseline T‐cell fitness and CAR‐T factors ...
Eitan Mirvis, Reuben Benjamin
wiley +1 more source
Clinical observations in acute neurology: A historical explanation of the present
European Journal of Neurology, Volume 31, Issue 11, November 2024.Abstract Background The history of the development of acute neurologic disease as a biologic mechanism is of interest. Equally important is how it translated to the bedside and how the clinical examination differentiated itself. Methods This paper reviews primary sources pertaining to acute neurologic conditions described mostly in the 19th and 20th ...
Eelco F. M. Wijdicks
wiley +1 more source
Veterinary Surgery, Volume 53, Issue 8, Page 1430-1437, November 2024.Abstract Objective To describe the approach for placement of a transcerebellar fourth ventriculoperitoneal shunt for management of presumed fourth ventricle arachnoid diverticulum and secondary obstructive hydrocephalus of a dog. To describe the outcome of this procedure. Study design Case report. Animals Male entire English springer spaniel, 3 years 9
Sophie Wyatt, Joe Fenn, Elsa Beltran
wiley +1 more source
Proceedings 35th Symposium ESVN‐ECVN
Journal of Veterinary Internal Medicine, Volume 39, Issue 2, March/April 2025.
wiley +1 more source
The Decerebrate State in the Primate
Archives of Neurology, 1971 Electromyographic analysis of postural reflexes in (1) patients considered "decerebrate," ie, manifesting the signs reported in monkeys with brain stem transection, (2) patients with upper motoneuron disorders, and (3) normal controls revealed in all groups a stereotyped extensor posturing especially of the forelimbs, called the reactive extensor ...
Shirley A. Sahrmann +2 more
+9 more sources
Postural Diplopia—Residuum of the Decerebrate State
Archives of Neurology, 1963 It is generally recognized that the appearance of the decerebrate state in patients harboring space-occupying intracranial lesions is of grave prognostic import. However, survival and recovery of such patients is well documented. 1 Survivors have exhibited varying degrees of neurological deficit, related to the decerebrate state as well as to its cause.
Robert M. Weiss
+7 more sources