Results 41 to 50 of about 6,165 (139)

The evolution of muscle spindles

Experimental Physiology, Volume 110, Issue 10, Page 1401-1421, October 1, 2025.
Abstract Muscle spindles are stretch‐sensitive mechanoreceptors found in the skeletal muscles of most four‐limbed vertebrates. They are unique amongst sensory receptors in the ability to regulate their sensitivity by contraction of the intrafusal muscle fibres on which the sensory endings lie.
Robert W. Banks, Uwe Proske
wiley   +1 more source

A Role for the Kolliker-Fuse Nucleus in Cholinergic Modulation of Breathing at Night During Wakefulness and NREM Sleep [PDF]

, 2010
For many years, acetylcholine has been known to contribute to the control of breathing and sleep. To probe further the contributions of cholinergic rostral pontine systems in control of breathing, we designed this study to test the hypothesis that ...
Bonis, Joshua M., Forster, Hubert V., Kiner, T., Krause, Katie L., Marshall, B. D., Neumueller, Suzanne E., Pan, Lawrence, Qian, B., Smith, A.   +8 more
core   +1 more source

Optogenetic methods to stimulate gamma motor neuron axons ex vivo

Experimental Physiology, Volume 110, Issue 10, Page 1531-1541, October 1, 2025.
Abstract It is challenging to stimulate gamma motor neurons, which are important regulators of muscle spindle afferent function, without also recruiting alpha motor neurons. Here, we test the feasibility of stimulating gamma motor neuron axons using optogenetics in two transgenic mouse lines. We used an ex vivo muscle–nerve preparation in adult mice to
Apoorva Karekal, Remie Mandawe, Cameron Chun, Sai Kiran Byri, Danitza Cheline, Serena Ortiz, Shawn Hochman, Katherine A. Wilkinson   +7 more
wiley   +1 more source

Avenues of future research in homotransplantation of the liver with particular reference to hepatic supportive procedures, antilymphocyte serum, and tissue typing [PDF]

, 1966
Three general areas of research which bear on the developing field of liver transplantation are reviewed. These are: (1) the prospects of obtaining better immunosuppression with particular reference to heterologous antilymphocyte serum; (2) the possible ...
Anderson, Bibler, Eiseman, Gray, Halgrimson, Hill, Jeejeebhoy, Marchioro, Mikaeloff, Monaco, Monaco, Norman, Patrick, Rich, Robert J. McCardle, Sacks, Starzl, Starzl, Starzl, Starzl, Steinberg, Tanous D. Faris, Thaler, Thomas E. Starzl, Thomas L. Marchioro, Vang, Waksman, Woodruff, Woodruff, Woodruff, Woodruff, Yoji Iwaski   +31 more
core   +1 more source

GsMTx‐4 inhibits the exercise pressor reflex and the muscle mechanoreflex primarily through TRPC inhibition

The Journal of Physiology, Volume 603, Issue 19, Page 5333-5350, October 1, 2025.
Abstract figure legend In decerebrated rats, injection of the TRPC6 channels antagonist (SAR7334) in the arterial supply of the triceps surae muscles was followed by injection of the TRPC6 and Piezo 2 channels antagonist (GsMTx‐4) to isolate the role of Piezo 2 in evoking the muscle mechanoreflex and exercise pressor reflex. The exercise pressor reflex
Guillaume P. Ducrocq, Laura Anselmi, Kristen Brandt, Jianli Wang, Victor Ruiz Velasco, Marc P. Kaufman   +5 more
wiley   +1 more source

Inhibition and potentiation of the exercise pressor reflex by pharmacological modulation of TRPC6 in male rats

The Journal of Physiology, Volume 603, Issue 18, Page 5027-5052, September 15, 2025.
Abstract figure legend The majority of L4–L5 dorsal root ganglion cells innervating the triceps surae muscles of healthy rats expressed TRPC6 channels. In decerebrated rats, pharmacological inhibition of TRPC6 channels by injection of antagonists (SAR7334 or BI‐749327) into the arterial supply of the triceps surae muscles inhibited the exercise pressor
Guillaume P. Ducrocq, Laura Anselmi, Salvatore L. Stella Jr, Steven W. Copp, Victor Ruiz‐Velasco, Marc P. Kaufman   +5 more
wiley   +1 more source

THE PSYCHOMOTOR THEORY OF HUMAN MIND [PDF]

, 2007
This study presents a new theory to explain the neural origins of human mind. This is the psychomotor theory. The author briefly analyzed the historical development of the mind-brain theories.
TAN, Prof. Dr. Uner
core   +1 more source

Lactate and hydrogen ions play a predominant role in evoking the exercise pressor reflex during ischaemic contractions but not during freely perfused contractions

The Journal of Physiology, Volume 603, Issue 18, Page 5053-5070, September 15, 2025.
Abstract figure legend The role of lactate and hydrogen ions in evoking the metabolic component of the exercise pressor reflex was studied in rats with either a functional pygm gene (pygm+/+) or with a non‐functional “knocked out” pygm gene (pygm−/−). The pygm gene is responsible for producing the myophosphorylase enzyme which catalyses the breakdown ...
Guillaume P. Ducrocq, Laura Anselmi, Victor Ruiz‐Velasco, Marc P. Kaufman   +3 more
wiley   +1 more source

Vomiting Center reanalyzed: An electrical stimulation study [PDF]

Electrical stimulation of the brainstem of 15 decerebrate cats produced stimulus-bound vomiting in only 4 animals. Vomiting was reproducible in only one cat.
Miller, A. D., Wilson, V. J.
core   +1 more source

Intracerebroventricular insulin injection acutely normalizes the augmented exercise pressor reflex in male rats with type 2 diabetes mellitus

The Journal of Physiology, Volume 603, Issue 18, Page 4991-5008, September 15, 2025.
Abstract figure legend The exercise pressor reflex (EPR), evoked by muscle contraction, is exaggerated in male rats with type 2 diabetes mellitus (T2DM). Cerebrospinal fluid insulin and phosphoinositide 3‐kinase in the nucleus tractus solitarius levels are normal in controls and low in T2DM rats, corresponding with normal and exaggerated EPR function ...
Juan A. Estrada, Rie Ishizawa, Han‐Kyul Kim, Ayumi Fukazawa, Amane Hori, Norio Hotta, Gary A. Iwamoto, Scott A. Smith, Wanpen Vongpatanasin, Masaki Mizuno   +9 more
wiley   +1 more source