Results 101 to 110 of about 39,716 (258)
Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer
Molecular Oncology, EarlyView.We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas +15 more
wiley +1 more source
Quantum computing architectures with signaling and control mimicking biological processes. [PDF]
Heliyon, 2023 Pau LF, Borza PN.
europepmc +1 more source
Molecular Oncology, EarlyView.Cancer stem cells are associated with aggressive disease, but a deep characterization of such markers is lacking in endometrial cancer. This study uses imaging mass cytometry to explore putative cancer stem cell markers in endometrial tumors and corresponding organoid models.
Hilde E. Lien +7 more
wiley +1 more source
Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance
Molecular Oncology, EarlyView.Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren +4 more
wiley +1 more source
On algorithmic decidability of the square-free word problem relative to a system of two defining relations [PDF]
arXiv, 2012 The square-free word problem relative to a system of two defining relations is decidable.
arxiv
Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer
Molecular Oncology, EarlyView.We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi +26 more
wiley +1 more source
Branch-Well-Structured Transition Systems and Extensions [PDF]
Logical Methods in Computer ScienceWe propose a relaxation to the definition of well-structured transition systems (\WSTS) while retaining the decidability of boundedness and non-termination.
Benedikt Bollig +2 more
doaj +1 more source
Deciding the Chromatic Numbers of Algebraic Hypergrahs [PDF]
arXiv, 2016 For each infinite cardinal k, the set of algebraic hypergraphs having chromatic number no larger than k is decidable.
arxiv
Federated Learning in Computational Toxicology: An Industrial Perspective on the Effiris Hackathon. [PDF]
Chem Res Toxicol, 2023 Bassani D, Brigo A, Andrews-Morger A.
europepmc +1 more source
Molecular Oncology, EarlyView.TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam +9 more
wiley +1 more source