Results 131 to 140 of about 494,097 (364)
A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms
FEBS Open Bio, EarlyView.We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley +1 more source
Query Answering over Contextualized RDF/OWL Knowledge with Forall-Existential Bridge Rules: Attaining Decidability using Acyclicity (full version) [PDF]
, 2014 Mathew Joseph +2 more
openalex +1 more source
Decidability of cutpoint isolation for probabilistic finite automata on\n letter-bounded inputs [PDF]
, 2020 Paul C. Bell, Pavel Semukhin
openalex +1 more source
Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays
FEBS Open Bio, EarlyView.We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul +3 more
wiley +1 more source
Agency—the ability to define one’s own goals and make choices to achieve them—is often measured through questions that capture an individual’s direct involvement in decision-making. Yet not participating in decision-making may not always imply a lack of power.
Hillesland, Marya +6 more
openaire +1 more source
Molecular determinants of signal transduction in tropomyosin receptor kinases
FEBS Open Bio, EarlyView.Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley +1 more source
FEBS Open Bio, EarlyView.Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani +7 more
wiley +1 more source
Decidability of Global Admissibility of Inference Rules in Logic $S4$
Известия Иркутского государственного университета: Серия "Математика"In the early 2000s, the key questions of the theory of admissible rules (decidability by admissibility, the presence of a basis) were resolved for most basic non-classical logics. The question arose about the direction of development of this theory.
V.V. Rimatskiy
doaj +1 more source
A review of data abstraction. [PDF]
Front Artif Intell, 2023 Cima G, Console M, Lenzerini M, Poggi A.
europepmc +1 more source
On the Use of MPC Techniques to Decide Intervention Policies against COVID-19
, 2021 Zonglin Liu, Olaf Stursberg
openalex +1 more source