Results 131 to 140 of about 49,212 (323)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
On Equivalence and Canonical Forms in the LF Type Theory
, 2000 Decidability of definitional equality and conversion of terms into canonical form play a central role in the meta-theory of a type-theoretic logical framework. Most studies of definitional equality are based on a confluent, strongly-normalizing notion of
Harper, Robert, Pfenning, Frank
core +10 more sources
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Decidability of Global Admissibility of Inference Rules in Logic $S4$
Известия Иркутского государственного университета: Серия "Математика"In the early 2000s, the key questions of the theory of admissible rules (decidability by admissibility, the presence of a basis) were resolved for most basic non-classical logics. The question arose about the direction of development of this theory.
V.V. Rimatskiy
doaj +1 more source
A review of data abstraction. [PDF]
Front Artif Intell, 2023 Cima G, Console M, Lenzerini M, Poggi A.
europepmc +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Toward an efficient algorithm for deciding the vanishing of local cohomology modules in prime characteristic [PDF]
, 2014 Yi Zhang
openalex +1 more source
FEBS Open Bio, EarlyView.KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli +9 more
wiley +1 more source