Results 141 to 150 of about 475,794 (375)

Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi   +26 more
wiley   +1 more source

Special Issue of Selected Extended Papers of IJCAR 2020. [PDF]

open access: yesJ Autom Reason, 2022
Peltier N, Sofronie-Stokkermans V.
europepmc   +1 more source

Infinite Time Turing Machines [PDF]

open access: yesarXiv, 1998
We extend in a natural way the operation of Turing machines to infinite ordinal time, and investigate the resulting supertask theory of computability and decidability on the reals. The resulting computability theory leads to a notion of computation on the reals and concepts of decidability and semi-decidability for sets of reals as well as individual ...
arxiv  

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

open access: yesMolecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam   +9 more
wiley   +1 more source

A review of data abstraction. [PDF]

open access: yesFront Artif Intell, 2023
Cima G, Console M, Lenzerini M, Poggi A.
europepmc   +1 more source

Strong equivalence of reversible circuits is coNP-complete [PDF]

open access: yesarXiv, 2013
It is well-known that deciding equivalence of logic circuits is a coNP-complete problem. As a corollary, the problem of deciding weak equivalence of reversible circuits, i.e. ignoring the ancilla bits, is also coNP-complete. The complexity of deciding strong equivalence, including the ancilla bits, is less obvious and may depend on gate set.
arxiv  

Enhancing patient engagement in cancer research: a focus on patient‐centric approaches to scientific discovery

open access: yesMolecular Oncology, EarlyView.
Patient engagement involves actively including patients in healthcare decisions and research to ensure care and studies align with their needs. This approach improves outcomes, trust, and communication while fostering collaboration between patients and professionals.
Estela Cepeda   +3 more
wiley   +1 more source

Decidability of the Monadic Shallow Linear First-Order Fragment with Straight Dismatching Constraints [PDF]

open access: yesarXiv, 2017
The monadic shallow linear Horn fragment is well-known to be decidable and has many application, e.g., in security protocol analysis, tree automata, or abstraction refinement. It was a long standing open problem how to extend the fragment to the non-Horn case, preserving decidability, that would, e.g., enable to express non-determinism in protocols. We
arxiv  

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

open access: yesMolecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes   +20 more
wiley   +1 more source

Home - About - Disclaimer - Privacy