Results 21 to 30 of about 18,499 (206)

Nested Selves: Self‐Organization and Shared Markov Blankets in Prenatal Development in Humans

Topics in Cognitive Science, EarlyView., 2023
Abstract The immune system is a central component of organismic function in humans. This paper addresses self‐organization of biological systems in relation to—and nested within—other biological systems in pregnancy. Pregnancy constitutes a fundamental state for human embodiment and a key step in the evolution and conservation of our species. While not
Anna Ciaunica, Michael Levin, Fernando E. Rosas, Karl Friston   +3 more
wiley   +1 more source

The Dual Role of HLA-C in Tolerance and Immunity at the Maternal-Fetal Interface

Frontiers in Immunology, 2019
To establish a healthy pregnancy, maternal immune cells must tolerate fetal allo-antigens and remain competent to respond to infections both systemically and in placental tissues.
Henrieta Papúchová, Torsten B. Meissner, Torsten B. Meissner, Qin Li, Jack L. Strominger, Tamara Tilburgs, Tamara Tilburgs   +6 more
doaj   +1 more source

Visualizing Dynamic Changes at the Maternal-Fetal Interface Throughout Human Pregnancy by Mass Cytometry

Frontiers in Immunology, 2020
During healthy pregnancy, a balanced microenvironment at the maternal-fetal interface with coordinated interaction between various immune cells is necessary to maintain immunological tolerance.
Anita van der Zwan, Vincent van Unen, Vincent van Unen, Guillaume Beyrend, Sandra Laban, Carin van der Keur, Hanneke J. M. Kapsenberg, Thomas Höllt, Thomas Höllt, Susana M. Chuva de Sousa Lopes, Marie-Louise P. van der Hoorn, Frits Koning, Frans H. J. Claas, Michael Eikmans, Sebastiaan Heidt   +14 more
doaj   +1 more source

Endometrial stromal cell miR-19b-3p release is reduced during decidualization implying a role in decidual-trophoblast cross-talk

Frontiers in Endocrinology, 2023
IntroductionA healthy pregnancy requires successful blastocyst implantation into an adequately prepared or ‘receptive’ endometrium. Decidualization of uterine endometrial stromal fibroblast cells (hESF) is critical for the establishment of a healthy ...
Ellen Menkhorst, Ellen Menkhorst, Teresa So, Teresa So, Kate Rainczuk, Siena Barton, Siena Barton, Wei Zhou, Wei Zhou, Tracey Edgell, Evdokia Dimitriadis, Evdokia Dimitriadis, Evdokia Dimitriadis   +12 more
doaj   +1 more source

Failure of Decidualization and Maternal Immune Tolerance Underlies Uterovascular Resistance in Intra Uterine Growth Restriction

Frontiers in Endocrinology, 2019
Failure of uterine vascular transformation is associated with pregnancy complications including Intra Uterine Growth Restriction (IUGR). The decidua and its immune cell populations play a key role in the earliest stages of this process.
Caroline Dunk, Melissa Kwan, Aleah Hazan, Sierra Walker, Julie K. Wright, Lynda K. Harris, Lynda K. Harris, Lynda K. Harris, Rebecca Lee Jones, Rebecca Lee Jones, Sarah Keating, John C. P. Kingdom, John C. P. Kingdom, Wendy Whittle, Cynthia Maxwell, Stephen J. Lye, Stephen J. Lye, Stephen J. Lye   +17 more
doaj   +1 more source

Thyroid hormones affect decidualization and angiogenesis in the decidua and metrial gland of rats

Pesquisa Veterinária Brasileira
: This study aimed to evaluate the effects of thyroid hormone on the decidua and metrial gland of rats and to examine the expression of angiogenic factors. 72 adult, female rats were divided into hypothyroid, T4-treated2, and control groups.
Cíntia A. Souza, Juneo F. Silva, Camila L.R. Silva, Natália M. Ocarino, Rogéria Serakides   +4 more
doaj   +1 more source

Estrogen and Progesterone Receptors Are Dysregulated at the BPH/5 Mouse Preeclamptic-Like Maternal–Fetal Interface

Biology
The etiopathogenesis of preeclampsia, a leading hypertensive disorder of pregnancy, has been proposed to involve an abnormal circulating sex hormone profile and misexpression of placental estrogen and progesterone receptors (ER and PR, respectively ...
Viviane C. L. Gomes, Bryce M. Gilbert, Carolina Bernal, Kassandra R. Crissman, Jenny L. Sones   +4 more
doaj   +1 more source

An Anti-inflammatory microRNA Signature Distinguishes Group 3 Innate Lymphoid Cells From Natural Killer Cells in Human Decidua

Frontiers in Immunology, 2020
Innate lymphoid cells (ILCs) are a heterogeneous subset of lymphocytes deeply implicated in the innate immune responses to different pathogens, in lymphoid organogenesis and in the maintenance of tissue homeostasis.
Andrea Pelosi, Claudia Alicata, Nicola Tumino, Tiziano Ingegnere, Fabrizio Loiacono, Maria Cristina Mingari, Maria Cristina Mingari, Maria Cristina Mingari, Lorenzo Moretta, Paola Vacca   +9 more
doaj   +1 more source

Perfluorooctanoic Acid Exposure Causes Macrophage Ammonia Retention and Induces Spontaneous Miscarriages

Advanced Science, EarlyView.
PFOA exposure induces pregnancy loss by promoting glutaminolysis, which further causes ammonia accumulation in macrophages. Cellular ammonia retention results in damage to mitochondria and lysosomes, which leads to cell death eventually. Impaired lysosomes also decrease the secretion of the Cathepsin B (CTSB), and attenuate macrophage infiltration and ...
Yongbo Zhao, Yijun Zhang, Hanyu Rao, Jiani Sun, Zhiyi Pan, Liping Jin, Yan Zhao   +6 more
wiley   +1 more source

Ectopic decidua of the appendix: a case report

Surgical Case Reports, 2021
Background Ectopic decidua is the presence of decidual tissue outside the uterus. Ectopic decidua of the appendix is a rare entity that can present with abdominal symptoms mimicking appendicitis.
Manabu Kaneko, Hiroaki Nozawa, Hirofumi Rokutan, Koji Murono, Tetsuo Ushiku, Soichiro Ishihara   +5 more
doaj   +1 more source