Results 1 to 10 of about 51,241 (234)

PPARG directs trophoblast cell fate and establishment of the uterine-placental interface [PDF]

EMBO Reports
The expansion and differentiation of trophoblast stem (TS) cells are critical for defining fundamental properties of the placenta. Specialized trophoblast cells called extravillous trophoblast (EVT) cells in human and invasive trophoblast cells in rat ...
Esteban M Dominguez, Ayelen Moreno-Irusta, Khursheed Iqbal, Keting Chen, Alex Finlinson, Marc Parrish, Hiroaki Okae, Takahiro Arima, Geetu Tuteja, Michael J Soares   +9 more
doaj   +2 more sources

Decidual macrophage‐mediated ferroptosis in trophoblasts leads to recurrent spontaneous abortion [PDF]

iMeta
Recurrent spontaneous abortion (RSA) poses a significant challenge to successful early pregnancy, and trophoblast cell ferroptosis is an important pathogenic mechanism of RSA.
Xin Chen, Xueqin Ma, Pengcheng Pang, Heng Zhou, Ruohan Li, Yan He, Yan Zhang, Jing Yang, Qianlin Song, Qingsong Ye   +9 more
doaj   +2 more sources

Arginine methyltransferase PRMT1 equipoises trophoblast development to prevent early pregnancy loss [PDF]

Nature Communications
Idiopathic recurrent pregnancy loss (RPL) affects 1–2% of human pregnancies, yet the underlying molecular causes are poorly understood. Here we identify defective Protein Arginine Methyltransferase 1 (PRMT1) function in trophoblast progenitors as a cause
Purbasa Dasgupta, Rajnish Kumar, Soma Ray, Namrata Roy, Asef Jawad Niloy, Mounika Vallakati, Courtney Marsh, Sebastian J. Arnold, Soumen Paul   +8 more
doaj   +2 more sources

Isolation of First-Trimester and Full-term Human Placental Hofbauer Cells

Bio-Protocol, 2021
The placenta is the crucial organ that regulates the health of both mother and fetus during pregnancy. The human placenta is composed of villous tree-like structures that embed into the maternal decidua.
Anna Appios, Jake Thomas, Naomi McGovern
doaj   +1 more source

Primitive haematopoiesis in the human placenta gives rise to macrophages with epigenetically silenced HLA-DR

Nature Communications, 2023
The generation of primitive macrophages remains a poorly understood process in humans. Here, the authors identify placental erythro-myeloid progenitors that give rise to foetal macrophages in the early human placenta and demonstrate that epigenetic ...
Jake R. Thomas, Anna Appios, Emily F. Calderbank, Nagisa Yoshida, Xiaohui Zhao, Russell S. Hamilton, Ashley Moffett, Andrew Sharkey, Elisa Laurenti, Courtney W. Hanna, Naomi McGovern   +10 more
doaj   +1 more source

Maternal and Fetal PI3K-p110α Deficiency Induces Sex-Specific Changes in Conceptus Growth and Placental Mitochondrial Bioenergetic Reserve in Mice

Veterinary Sciences, 2022
Fetal growth is reliant on placental formation and function, which, in turn, requires the energy produced by the mitochondria. Prior work has shown that both mother and fetus operate via the phosphoinositol 3-kinase (PI3K)-p110α signalling pathway to ...
Daniela Pereira-Carvalho, Esteban Salazar-Petres, Jorge Lopez-Tello, Amanda N. Sferruzzi-Perri   +3 more
doaj   +1 more source

Elevated homocysteine activates unfolded protein responses and causes aberrant trophoblast differentiation and mouse blastocyst development

Physiological Reports, 2022
Hyperhomocysteinemia may arise from folate/vitamin B12 deficiency, genetic polymorphisms, kidney disease, or hypothyroidism. It is associated with an increased risk of early pregnancy loss and placenta‐related complications of pregnancy, including pre ...
Nadejda Capatina, Graham J. Burton, Hong Wa Yung   +2 more
doaj   +1 more source

Placental secretome characterization identifies candidates for pregnancy complications

Communications Biology, 2021
Napso et al. identify proteins from mouse placental endocrine cells and create a comprehensive secretome map of the placenta. The authors compare this secretome map with human placental datasets from women with pregnancy complications and demonstrate the
Tina Napso, Xiaohui Zhao, Marta Ibañez Lligoña, Ionel Sandovici, Richard G. Kay, Amy L. George, Fiona M. Gribble, Frank Reimann, Claire L. Meek, Russell S. Hamilton, Amanda N. Sferruzzi-Perri   +10 more
doaj   +1 more source

RNA-Seq reveals changes in human placental metabolism, transport and endocrinology across the first–second trimester transition

Biology Open, 2021
The human placenta is exposed to major environmental changes towards the end of the first trimester associated with full onset of the maternal arterial placental circulation.
Malwina Prater, Russell S. Hamilton, Hong Wa Yung, Andrew M. Sharkey, Paul Robson, N. Erlyani Abd Hamid, Eric Jauniaux, D. Stephen Charnock-Jones, Graham J. Burton, Tereza Cindrova-Davies   +9 more
doaj   +1 more source

Maternal and Intrauterine Influences on Feto-Placental Growth Are Accompanied by Sexually Dimorphic Changes in Placental Mitochondrial Respiration, and Metabolic Signalling Pathways

Cells, 2023
Adverse maternal environments such as small size, malnutrition, and metabolic conditions are known to influence fetal growth outcomes. Similarly, fetal growth and metabolic alterations may alter the intrauterine environment and affect all fetuses in ...
Esteban Salazar-Petres, Daniela Pereira-Carvalho, Jorge Lopez-Tello, Amanda N. Sferruzzi-Perri   +3 more
doaj   +1 more source