Results 1 to 10 of about 88,307 (280)

HAND1 controls the lineage bifurcation of trophoblast and amnion from human pluripotent stem cells [PDF]

Cellular and Molecular Life Sciences
Trophoblast and amniotic lineages, representing key extra-embryonic tissues, can be differentiated from human pluripotent stem cells (hPSCs) under chemically defined conditions.
Changmiao Pang, Qifeng Yang, Yulong Zhong, Jinhao Ye, Yufang Lv, Shufei Xie, Yanqing Tang, Xianhua Ye, Feifan Zhang, Chao Li, Jingyi Zhang, Liangzhong Sun, Shanshan Ai, Xuefei Gao   +13 more
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Transient inhibition of MEK/ERK and WNT pathways enhances direct differentiation of primed hPSCs into functional trophoblast stem cells [PDF]

Cell Regeneration
The placenta plays a pivotal role in human pregnancy, yet research into placental development has been hindered by limited access to early-stage embryos and ethical constraints.
Qifan Jiang, Ping Liu, Chunlin Chen
doaj   +2 more sources

Progesterone receptor antagonism by mifepristone impairs trophoblast stemness and promotes apoptosis through upregulation of PDCD4 [PDF]

Cell & Bioscience
Background Trophoblast cells are a critical component of retained products of conception (RPOC). While mifepristone is widely used as a non-invasive treatment for RPOC, its precise molecular mechanisms in trophoblast regulation remain poorly defined ...
Jie Zhou, Li Yan, Yamei Li, Suming Huang, Qicheng Lan, Duo Zhang, Qian Zhu, Xiaoya Zhao, Jian Zhang   +8 more
doaj   +2 more sources

Control of human endometrial stromal cell motility by PDGF-BB, HB-EGF and trophoblast-secreted factors [PDF]

, 2013
Human implantation involves extensive tissue remodeling at the fetal-maternal interface. It is becoming increasingly evident that not only trophoblast, but also decidualizing endometrial stromal cells are inherently motile and invasive, and likely ...
A Brar, A Samalecos, A Stavreus-Evers, AA Brahmbhatt, Ana-Maria Bamberger, Anja Wolf, Annemarie Samalecos, AT Fazleabas, B Cloke, B Gellersen, B Gellersen, BA Lessey, Birgit Gellersen, C Ferretti, C Fischer, C Gaggioli, Charlotte H. E. Weimar, CHE Weimar, CM Boomsma, CP Thomas, D Gentilini, D Gentilini, D Haouzi, DE Clark, EE Sander, ER Norwitz, F Chang, F Llorens, F Lyall, G Gaus, G Teklenburg, G Teklenburg, GE Lash, GE Lash, GJ Burton, H Funayama, H Matsumoto, H Xie, HJ Lim, HJ Yoo, I Ihnatovych, IY Yotova, J Anacker, J Baulida, J Fiedler, JJ Brosens, JJ Brosens, JW Tullai, JX Zhu, K Chobotova, K Kawada, K Red-Horse, K Roepstorff, LA Salamonsen, M Bilban, M Bilban, M Cohen, M Gonzalez, M Knöfler, M Knöfler, M Salker, Maren Schwenke, Martin Knöfler, Meijing Wang, Michelle Kruse, MW Maijenburg, Nick S. Macklon, NJ Hannan, NJ Hannan, P Burke, P Jessmon, P Jessmon, P Kaufmann, Philipp Velicky, R Apps, RE Leach, RE Leach, RE Leach, RJ Petrie, RL Kendall, RN Popovici, S Grewal, S Grewal, SK Mitra, Y Jiang, Y Yamazaki   +85 more
core   +15 more sources

Isolation of First-Trimester and Full-term Human Placental Hofbauer Cells

Bio-Protocol, 2021
The placenta is the crucial organ that regulates the health of both mother and fetus during pregnancy. The human placenta is composed of villous tree-like structures that embed into the maternal decidua.
Anna Appios, Jake Thomas, Naomi McGovern
doaj   +1 more source

Primitive haematopoiesis in the human placenta gives rise to macrophages with epigenetically silenced HLA-DR

Nature Communications, 2023
The generation of primitive macrophages remains a poorly understood process in humans. Here, the authors identify placental erythro-myeloid progenitors that give rise to foetal macrophages in the early human placenta and demonstrate that epigenetic ...
Jake R. Thomas, Anna Appios, Emily F. Calderbank, Nagisa Yoshida, Xiaohui Zhao, Russell S. Hamilton, Ashley Moffett, Andrew Sharkey, Elisa Laurenti, Courtney W. Hanna, Naomi McGovern   +10 more
doaj   +1 more source

Maternal and Fetal PI3K-p110α Deficiency Induces Sex-Specific Changes in Conceptus Growth and Placental Mitochondrial Bioenergetic Reserve in Mice

Veterinary Sciences, 2022
Fetal growth is reliant on placental formation and function, which, in turn, requires the energy produced by the mitochondria. Prior work has shown that both mother and fetus operate via the phosphoinositol 3-kinase (PI3K)-p110α signalling pathway to ...
Daniela Pereira-Carvalho, Esteban Salazar-Petres, Jorge Lopez-Tello, Amanda N. Sferruzzi-Perri   +3 more
doaj   +1 more source

Elevated homocysteine activates unfolded protein responses and causes aberrant trophoblast differentiation and mouse blastocyst development

Physiological Reports, 2022
Hyperhomocysteinemia may arise from folate/vitamin B12 deficiency, genetic polymorphisms, kidney disease, or hypothyroidism. It is associated with an increased risk of early pregnancy loss and placenta‐related complications of pregnancy, including pre ...
Nadejda Capatina, Graham J. Burton, Hong Wa Yung   +2 more
doaj   +1 more source

Placental secretome characterization identifies candidates for pregnancy complications

Communications Biology, 2021
Napso et al. identify proteins from mouse placental endocrine cells and create a comprehensive secretome map of the placenta. The authors compare this secretome map with human placental datasets from women with pregnancy complications and demonstrate the
Tina Napso, Xiaohui Zhao, Marta Ibañez Lligoña, Ionel Sandovici, Richard G. Kay, Amy L. George, Fiona M. Gribble, Frank Reimann, Claire L. Meek, Russell S. Hamilton, Amanda N. Sferruzzi-Perri   +10 more
doaj   +1 more source

RNA-Seq reveals changes in human placental metabolism, transport and endocrinology across the first–second trimester transition

Biology Open, 2021
The human placenta is exposed to major environmental changes towards the end of the first trimester associated with full onset of the maternal arterial placental circulation.
Malwina Prater, Russell S. Hamilton, Hong Wa Yung, Andrew M. Sharkey, Paul Robson, N. Erlyani Abd Hamid, Eric Jauniaux, D. Stephen Charnock-Jones, Graham J. Burton, Tereza Cindrova-Davies   +9 more
doaj   +1 more source