Results 21 to 30 of about 51,241 (234)

Application of a JEG-3 organoid model to study HLA-G function in the trophoblast

Frontiers in Immunology, 2023
The human placenta is a unique temporary organ with a mysterious immune tolerance. The formation of trophoblast organoids has advanced the study of placental development.
Bai-Mei Zhuang, Bai-Mei Zhuang, Dan-Dan Cao, Xiao-Feng Liu, Li Wang, Xiao-Li Lin, Yong-Gang Duan, Cheuk-Lun Lee, Cheuk-Lun Lee, Philip C. N. Chiu, Philip C. N. Chiu, William S. B. Yeung, William S. B. Yeung, Yuan-Qing Yao, Yuan-Qing Yao, Yuan-Qing Yao   +15 more
doaj   +1 more source

BPDE induces human trophoblast cell ferroptosis by up-regulating iron metabolism and promoting GPX4 proteasomal degradation

Ecotoxicology and Environmental Safety, 2021
Human trophoblast cells play important role in embryo-fetal development. However, trophoblast cells are sensitive to environmental carcinogens. Recently, we have discovered that BPDE inhibits trophoblast cell migration, invasion and proliferation, and ...
Peng Tian, Zhongyan Xu, Jiarong Guo, Jingsong Zhao, Rong Wang, Weina Chen, Yang Yang, Wenxin Huang, Chenyang Mi, Huidong Zhang   +9 more
doaj   +1 more source

Regulation of Placental Development and Its Impact on Fetal Growth—New Insights From Mouse Models

Frontiers in Endocrinology, 2018
The placenta is the chief regulator of nutrient supply to the growing embryo during gestation. As such, adequate placental function is instrumental for developmental progression throughout intrauterine development.
Laura Woods, Laura Woods, Vicente Perez-Garcia, Vicente Perez-Garcia, Myriam Hemberger, Myriam Hemberger   +5 more
doaj   +1 more source

Fetal and trophoblast PI3K p110α have distinct roles in regulating resource supply to the growing fetus in mice

eLife, 2019
Studies suggest that placental nutrient supply adapts according to fetal demands. However, signaling events underlying placental adaptations remain unknown.
Jorge López-Tello, Vicente Pérez-García, Jaspreet Khaira, Laura C Kusinski, Wendy N Cooper, Adam Andreani, Imogen Grant, Edurne Fernández de Liger, Brian YH Lam, Myriam Hemberger, Ionel Sandovici, Miguel Constancia, Amanda N Sferruzzi-Perri   +12 more
doaj   +1 more source

Extracellular Vesicles of Porphyromonas gingivalis Disrupt Trophoblast Cell Interaction with Vascular and Immune Cells in an In Vitro Model of Early Placentation

Life, 2023
Extracellular vesicles released by the primary pathogen of periodontal disease Porphyromonas gingivalis (Pg), referred to as outer membrane vesicles (OMVs), have been associated with the pathogenesis of systemic diseases like cardiovascular disease ...
Brenda Lara, Matías Sassot, Guillermina Calo, Daniel Paparini, Laura Gliosca, Gabriela Chaufan, Iñaki Loureiro, Daiana Vota, Rosanna Ramhorst, Claudia Pérez Leirós, Vanesa Hauk   +10 more
doaj   +1 more source

RBM10 Regulates Embryonic Trophoblast Injury via Endoplasmic Reticulum Stress

Clinical and Experimental Obstetrics & Gynecology, 2022
Background: Previous studies shown that RNA binding motif proteins (RBM) participate in regulating various physiological processes such as cell autophagy, proliferation, and apoptosis, and are abnormally highly expressed in placental trophoblast cells ...
Xiao Chen, Juan Du, Liyu Chen, Lanlan Wang, Gang Xin   +4 more
doaj   +1 more source

A Critical Role of TET1/2 Proteins in Cell-Cycle Progression of Trophoblast Stem Cells

Stem Cell Reports, 2018
Summary: The ten-eleven translocation (TET) proteins are well known for their role in maintaining naive pluripotency of embryonic stem cells. Here, we demonstrate that, jointly, TET1 and TET2 also safeguard the self-renewal potential of trophoblast stem ...
Stephanie Chrysanthou, Claire E. Senner, Laura Woods, Elena Fineberg, Hanneke Okkenhaug, Sarah Burge, Vicente Perez-Garcia, Myriam Hemberger   +7 more
doaj   +1 more source

Environmental BPDE induced human trophoblast cell apoptosis by up-regulating lnc-HZ01/p53 positive feedback loop

Ecotoxicology and Environmental Safety, 2022
Human trophoblast cell apoptosis may induce miscarriage. Trophoblast cells are sensitive to environmental BaP-7,8-dihydrodiol-9,10-epoxide (BPDE). However, how BPDE induces human trophoblast cell apoptosis is still largely elusive.
Xinying Huang, Chenglong Ma, Wenxin Huang, Mengyuan Dai, Jingjing Yang, Xiaole Xu, Yuanlv Deng, Yang Yang, Huidong Zhang   +8 more
doaj   +1 more source

The Trophoblast: A Rejoinder [PDF]

Science, 1904
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openaire   +2 more sources

Cooperation between NSPc1 and DNA methylation represses HOXA11 expression and promotes apoptosis of trophoblast cells during preeclampsia

Acta Biochimica et Biophysica Sinica, 2023
Accumulating evidence has shown that the apoptosis of trophoblast cells plays an important role in the pathogenesis of preeclampsia, and an intricate interplay between DNA methylation and polycomb group (PcG) protein-mediated gene silencing has been ...
Xie Lin, Ding Ning, Sheng Siqi, Zhang Honghong, Yin He, Gao Lina, Zhang Hui, Ma Shengchao, Yang Anning, Li Guizhong, Jiao Yun, Shi Qing, Jiang Yideng, Zhang Huiping   +13 more
doaj   +1 more source