Results 1 to 10 of about 46,140 (234)

Derivation of Mouse Haploid Trophoblast Stem Cells

Cell Reports, 2019
Summary: Trophoblast stem (TS) cells are increasingly used as a model system for studying placentation and placental disorders. However, practical limitations of genetic manipulation have posed challenges for genetic analysis using TS cells.
Tongtong Cui, Liyuan Jiang, Tianda Li, Fei Teng, Guihai Feng, Xuepeng Wang, Zhengquan He, Lu Guo, Kai Xu, Yihuan Mao, Leyun Wang, Xuewei Yuan, Liu Wang, Wei Li, Qi Zhou   +14 more
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12-Oxoeicosatetraenoic acid, a candidate signal for placenta separation, activates matrix metalloproteinase and induces apoptosis in bovine trophoblast cells [PDF]

Animal Bioscience, 2023
Objective 12-oxo-5Z,8Z,10E,14Z-eicosatetraenoic acid (12-KETE), a metabolite of arachidonic acid, is a strong candidate signal for placenta separation following calf discharge at delivery.
Hachiro Kamada
doaj   +1 more source

(Dis)similarities between the Decidual and Tumor Microenvironment

Biomedicines, 2022
Placenta-specific trophoblast and tumor cells exhibit many common characteristics. Trophoblast cells invade maternal tissues while being tolerated by the maternal immune system.
Jelena Krstic, Alexander Deutsch, Julia Fuchs, Martin Gauster, Tina Gorsek Sparovec, Ursula Hiden, Julian Christopher Krappinger, Gerit Moser, Katrin Pansy, Marta Szmyra, Daniela Gold, Julia Feichtinger, Berthold Huppertz   +12 more
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RBM10 Regulates Embryonic Trophoblast Injury via Endoplasmic Reticulum Stress

Clinical and Experimental Obstetrics & Gynecology, 2022
Background: Previous studies shown that RNA binding motif proteins (RBM) participate in regulating various physiological processes such as cell autophagy, proliferation, and apoptosis, and are abnormally highly expressed in placental trophoblast cells ...
Xiao Chen, Juan Du, Liyu Chen, Lanlan Wang, Gang Xin   +4 more
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Kisspeptin regulation of genes involved in cell invasion and angiogenesis in first trimester human trophoblast cells. [PDF]

PLoS ONE, 2014
The precise regulation of extravillous trophoblast invasion of the uterine wall is a key process in successful pregnancies. Kisspeptin (KP) has been shown to inhibit cancer cell metastasis and placental trophoblast cell migration.
Víctor A Francis, Aron B Abera, Mushi Matjila, Robert P Millar, Arieh A Katz   +4 more
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Inhibition of LAMP3 mediates the protective effect of vitamin D against hypoxia/reoxygenation in trophoblast cells

Brazilian Journal of Medical and Biological Research, 2023
Inadequate invasion and excessive apoptosis of trophoblast cells are associated with the development of preeclampsia. Vitamin D deficiency in pregnant women may lead to an increased risk of preeclampsia.
Xiaoyu Tian, Lili Zheng, Jing Ma, Ying Xu, Yulin Zhang, Yalei Pi   +5 more
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Trans-differentiation of trophoblast stem cells: implications in placental biology

Life Science Alliance, 2023
Formation of trophendothelial cells is associated with trophoblast differentiation and is regulated by HES1. Trophoblast differentiation–induced TRAIL secretion directs preferential demise of ECs located in their vicinity, aiding trophoblast vasculogenic
Madhurima Paul, Shreeta Chakraborty, Safirul Islam, Rupasri Ain   +3 more
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Extracellular Vesicles of Porphyromonas gingivalis Disrupt Trophoblast Cell Interaction with Vascular and Immune Cells in an In Vitro Model of Early Placentation

Life, 2023
Extracellular vesicles released by the primary pathogen of periodontal disease Porphyromonas gingivalis (Pg), referred to as outer membrane vesicles (OMVs), have been associated with the pathogenesis of systemic diseases like cardiovascular disease ...
Brenda Lara, Matías Sassot, Guillermina Calo, Daniel Paparini, Laura Gliosca, Gabriela Chaufan, Iñaki Loureiro, Daiana Vota, Rosanna Ramhorst, Claudia Pérez Leirós, Vanesa Hauk   +10 more
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BPDE induces human trophoblast cell ferroptosis by up-regulating iron metabolism and promoting GPX4 proteasomal degradation

Ecotoxicology and Environmental Safety, 2021
Human trophoblast cells play important role in embryo-fetal development. However, trophoblast cells are sensitive to environmental carcinogens. Recently, we have discovered that BPDE inhibits trophoblast cell migration, invasion and proliferation, and ...
Peng Tian, Zhongyan Xu, Jiarong Guo, Jingsong Zhao, Rong Wang, Weina Chen, Yang Yang, Wenxin Huang, Chenyang Mi, Huidong Zhang   +9 more
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Hyperactivated Wnt-β-catenin signaling in the absence of sFRP1 and sFRP5 disrupts trophoblast differentiation through repression of Ascl2

BMC Biology, 2020
Background Wnt signaling is a critical determinant for the maintenance and differentiation of stem/progenitor cells, including trophoblast stem cells during placental development.
Haili Bao, Dong Liu, Yingchun Xu, Yang Sun, Change Mu, Yongqin Yu, Chunping Wang, Qian Han, Sanmei Liu, Han Cai, Fan Liu, Shuangbo Kong, Wenbo Deng, Bin Cao, Haibin Wang, Qiang Wang, Jinhua Lu   +16 more
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