Trophoblast stem cells differentiate in vitro into invasive trophoblast giant cells
Developmental Biology, 2004 Trophoblast cells are characterized by an invasive behavior into the surrounding uterine tissue. In rodents, an early peri-/endovascular type of invasion exerted by trophoblast giant cells can be distinguished from a late interstitial type carried out by glycogen trophoblast cells.
Myriam Hemberger, James C Cross
exaly +4 more sources
Mechanism of hsa_circ_0069443 promoting early pregnancy loss through ALKBH5/FN1 axis in trophoblast cells [PDF]
iScienceSummary: Studies have shown that circRNAs play an important regulatory role in trophoblast function and embryonic development. Based on sequencing and functional experiments, we found that hsa_circ_0069443 can regulate the function of trophoblast cells ...
Bai-xue Li +8 more
doaj +2 more sources
Derivation of Mouse Haploid Trophoblast Stem Cells
Cell Reports, 2019 Summary: Trophoblast stem (TS) cells are increasingly used as a model system for studying placentation and placental disorders. However, practical limitations of genetic manipulation have posed challenges for genetic analysis using TS cells.
Tongtong Cui +14 more
doaj +3 more sources
12-Oxoeicosatetraenoic acid, a candidate signal for placenta separation, activates matrix metalloproteinase and induces apoptosis in bovine trophoblast cells [PDF]
Animal Bioscience, 2023 Objective 12-oxo-5Z,8Z,10E,14Z-eicosatetraenoic acid (12-KETE), a metabolite of arachidonic acid, is a strong candidate signal for placenta separation following calf discharge at delivery.
Hachiro Kamada
doaj +1 more source
(Dis)similarities between the Decidual and Tumor Microenvironment
Biomedicines, 2022 Placenta-specific trophoblast and tumor cells exhibit many common characteristics. Trophoblast cells invade maternal tissues while being tolerated by the maternal immune system.
Jelena Krstic +12 more
doaj +1 more source
RBM10 Regulates Embryonic Trophoblast Injury via Endoplasmic Reticulum Stress
Clinical and Experimental Obstetrics & Gynecology, 2022 Background: Previous studies shown that RNA binding motif proteins (RBM) participate in regulating various physiological processes such as cell autophagy, proliferation, and apoptosis, and are abnormally highly expressed in placental trophoblast cells ...
Xiao Chen +4 more
doaj +1 more source
Kisspeptin regulation of genes involved in cell invasion and angiogenesis in first trimester human trophoblast cells. [PDF]
PLoS ONE, 2014 The precise regulation of extravillous trophoblast invasion of the uterine wall is a key process in successful pregnancies. Kisspeptin (KP) has been shown to inhibit cancer cell metastasis and placental trophoblast cell migration.
Víctor A Francis +4 more
doaj +1 more source
Brazilian Journal of Medical and Biological Research, 2023 Inadequate invasion and excessive apoptosis of trophoblast cells are associated with the development of preeclampsia. Vitamin D deficiency in pregnant women may lead to an increased risk of preeclampsia.
Xiaoyu Tian +5 more
doaj +1 more source
Immunobiology of trophoblast cells [PDF]
Indian Journal of Clinical Biochemistry, 2000 Trophoblast cells contribute in all the stages of pregnancy starting from implantation of the embryo to parturition through their unique inherent properties of invasion, proliferation, differentiation and endocrine secretions. Hence, successful outcome of pregnancy depends greatly on the coordinated functioning of the trophoblast cells which is brouth ...
C, Das +4 more
openaire +2 more sources
Trans-differentiation of trophoblast stem cells: implications in placental biology
Life Science Alliance, 2023 Formation of trophendothelial cells is associated with trophoblast differentiation and is regulated by HES1. Trophoblast differentiation–induced TRAIL secretion directs preferential demise of ECs located in their vicinity, aiding trophoblast vasculogenic
Madhurima Paul +3 more
doaj +1 more source