Results 11 to 20 of about 51,707 (295)

Establishment of Bovine Trophoblast Stem Cells

Cell Reports, 2022
Abstract Here we report that a chemical cocktail (LCDM: h L IF, C HIR99021, D iM and M iH) previously used for extended potential pluripotent stem cells enables the de novo ...
Yinjuan Wang, Leqian Yu, Jie Li, Linkai Zhu, Hao Ming, Carlos Pinzon Arteaga, Hai-Xi Sun, Jun Wu, Zongliang Jiang   +8 more
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Here and there a trophoblast, a transcriptional evaluation of trophoblast cell models

Cellular and Molecular Life Sciences, 2022
Abstract A recent explosion of methods to produce human trophoblasts and stem cells (hTSC) is fuelling a renewed interest in this tissue. The trophoblast is critical to reproduction by facilitating implantation, maternal physiological adaptations to pregnancy and the growth of the fetus through transport of nutrients between the mother and ...
Brian Joseph Cox, Kendra Naismith
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BPDE induces human trophoblast cell ferroptosis by up-regulating iron metabolism and promoting GPX4 proteasomal degradation

Ecotoxicology and Environmental Safety, 2021
Human trophoblast cells play important role in embryo-fetal development. However, trophoblast cells are sensitive to environmental carcinogens. Recently, we have discovered that BPDE inhibits trophoblast cell migration, invasion and proliferation, and ...
Peng Tian, Zhongyan Xu, Jiarong Guo, Jingsong Zhao, Rong Wang, Weina Chen, Yang Yang, Wenxin Huang, Chenyang Mi, Huidong Zhang   +9 more
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Extracellular Vesicles of Porphyromonas gingivalis Disrupt Trophoblast Cell Interaction with Vascular and Immune Cells in an In Vitro Model of Early Placentation

Life, 2023
Extracellular vesicles released by the primary pathogen of periodontal disease Porphyromonas gingivalis (Pg), referred to as outer membrane vesicles (OMVs), have been associated with the pathogenesis of systemic diseases like cardiovascular disease ...
Brenda Lara, Matías Sassot, Guillermina Calo, Daniel Paparini, Laura Gliosca, Gabriela Chaufan, Iñaki Loureiro, Daiana Vota, Rosanna Ramhorst, Claudia Pérez Leirós, Vanesa Hauk   +10 more
doaj   +1 more source

Hyperactivated Wnt-β-catenin signaling in the absence of sFRP1 and sFRP5 disrupts trophoblast differentiation through repression of Ascl2

BMC Biology, 2020
Background Wnt signaling is a critical determinant for the maintenance and differentiation of stem/progenitor cells, including trophoblast stem cells during placental development.
Haili Bao, Dong Liu, Yingchun Xu, Yang Sun, Change Mu, Yongqin Yu, Chunping Wang, Qian Han, Sanmei Liu, Han Cai, Fan Liu, Shuangbo Kong, Wenbo Deng, Bin Cao, Haibin Wang, Qiang Wang, Jinhua Lu   +16 more
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Phenotypic Profile of Peripheral Blood NK Cells under Culturing with Trophoblast Cells and IL-15 and IL-18 Cytokines

Медицинская иммунология, 2021
Natural killer cells (NK cells) are innate immunity lymphocytes. NK cell differentiation is controlled by the cellular microenvironment and locally produced cytokines, including IL-2, IL-15 and IL-18.
V. A. Mikhailova, P. V. Grebenkina, E. V. Tyshchuk, A. A. Davydova, V. A. Zagaynova, I. Yu. Kogan, S. A. Selkov, D. I. Sokolov   +7 more
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Cooperation between NSPc1 and DNA methylation represses HOXA11 expression and promotes apoptosis of trophoblast cells during preeclampsia

Acta Biochimica et Biophysica Sinica, 2023
Accumulating evidence has shown that the apoptosis of trophoblast cells plays an important role in the pathogenesis of preeclampsia, and an intricate interplay between DNA methylation and polycomb group (PcG) protein-mediated gene silencing has been ...
Xie Lin, Ding Ning, Sheng Siqi, Zhang Honghong, Yin He, Gao Lina, Zhang Hui, Ma Shengchao, Yang Anning, Li Guizhong, Jiao Yun, Shi Qing, Jiang Yideng, Zhang Huiping   +13 more
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Alkaloid leonurine exerts anti‐inflammatory effects via modulating MST1 expression in trophoblast cells

Immunity, Inflammation and Disease, 2021
Background Pre‐eclampsia (PE) is mainly attributed to the inflammation of trophoblast cells in pregnant women, which results in damage to the maternal organs and growth retardation of the fetus.
Fang Zong, Yingzi Zhao
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Environmental BPDE induced human trophoblast cell apoptosis by up-regulating lnc-HZ01/p53 positive feedback loop

Ecotoxicology and Environmental Safety, 2022
Human trophoblast cell apoptosis may induce miscarriage. Trophoblast cells are sensitive to environmental BaP-7,8-dihydrodiol-9,10-epoxide (BPDE). However, how BPDE induces human trophoblast cell apoptosis is still largely elusive.
Xinying Huang, Chenglong Ma, Wenxin Huang, Mengyuan Dai, Jingjing Yang, Xiaole Xu, Yuanlv Deng, Yang Yang, Huidong Zhang   +8 more
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Fosl1 overexpression directly activates trophoblast-specific gene expression programs in embryonic stem cells

Stem Cell Research, 2018
During early development in placental mammals, proper trophoblast lineage development is essential for implantation and placentation. Defects in this lineage can cause early pregnancy failures and other pregnancy disorders. However, transcription factors
Bum-Kyu Lee, Nadima Uprety, Yu Jin Jang, Scott K. Tucker, Catherine Rhee, Lucy LeBlanc, Samuel Beck, Jonghwan Kim   +7 more
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