Results 41 to 50 of about 51,707 (295)

Extravillous trophoblast cell lineage development is associated with active remodeling of the chromatin landscape

Nature Communications, 2023
The extravillous trophoblast cell lineage is a key feature of placentation and successful pregnancy. Knowledge of transcriptional regulation driving extravillous trophoblast cell development is limited.
Kaela M. Varberg, Esteban M. Dominguez, Boryana Koseva, Joseph M. Varberg, Ross P. McNally, Ayelen Moreno-Irusta, Emily R. Wesley, Khursheed Iqbal, Warren A. Cheung, Carl Schwendinger-Schreck, Craig Smail, Hiroaki Okae, Takahiro Arima, Michael Lydic, Kristin Holoch, Courtney Marsh, Michael J. Soares, Elin Grundberg   +17 more
doaj   +1 more source

NK cells, hypoxia and trophoblast cell differentiation [PDF]

Cell Cycle, 2012
Hemochorial placentation is characterized by extensive remodeling of the maternal vasculature, converting them to flaccid low resistance vessels. This process greatly facilitates exchange of nutrients and gases between the mother and the fetus. Two key modulators that orchestrate these vascular changes have been identified at the maternal fetal ...
Damayanti, Chakraborty, M A Karim, Rumi, Michael J, Soares   +2 more
openaire   +2 more sources

N-glycans of human amniotic fluid transferrin stimulate progesterone production in human first trimester trophoblast cells in vitro [PDF]

, 2004
Aims: During pregnancy, the placenta produces a variety of steroid hormones and proteins. Several of these substances have been shown to exert immunomodulatory effects.
Briese, V., Friese, K., Richter, D.-U., Gundel, G., Mylonas, I., Unverzagt, C., Jeschke, U., Müller, H., Streu, A.   +8 more
core   +1 more source

Decidual natural killer cells and trophoblast cells: cellular, humoral and molecular mechanisms of interaction

Медицинская иммунология, 2022
Natural killer cells (NK cells) represent a group of lymphocytes of innate immunity. In addition to NK cells of peripheral blood, tissue-resident populations are described.
P. V. Grebenkina, V. A. Mikhailova, A. A. Oshkolova, S. O. Vershinina, M. S. Dukhinova, D. O. Bazhenov, S. A. Selkov, D. I. Sokolov   +7 more
doaj   +1 more source

Stimulation of hCG protein and mRNA in first trimester villous cytotrophoblast cells in vitro by glycodelin A [PDF]

, 2005
Aim: Human chorionic gonadotropin (hCG) is produced by fetal trophoblast cells and secreted into maternal circulation mainly in the first trimester of pregnancy.
Richter, Dagmar-Ulrike, Bergemann, Claudia, Jeschke, Udo, Jeschke, U., Reimer, T., Richter, D.U., Karsten, U., Briese, V., Briese, Volker, Friese, K., Reimer, Toralf, Mylonas, Ioannis, Bergemann, C., Mylonas, L., Friese, Klaus, Karsten, Uwe   +15 more
core   +1 more source

NOSTRIN: A novel modulator of trophoblast giant cell differentiation

Stem Cell Research, 2018
Differentiation-dependent expression of NOSTRIN in murine trophoblast cells prompted investigation on NOSTRIN's function in trophoblast differentiation. We show here that NOSTRIN levels increased in both mouse and rat placenta during gestation.
Shreeta Chakraborty, Rupasri Ain
doaj   +1 more source

A Unique Expression of Keratin 14 in a Subset of Trophoblast Cells. [PDF]

PLoS ONE, 2015
The placenta, a transient organ in human, is essential for pregnancy maintenance and for fetal growth and development. Trophoblast and stromal cells are the main cell types present in human placenta.
Wassim Abou-Kheir, Assaad Eid, Rabih El-Merahbi, Rebecca Assaf, Georges Daoud   +4 more
doaj   +1 more source

Induction of human trophoblast stem cells

Nature Protocols, 2022
Cell reprogramming has allowed unprecedented access to human development, from virtually any genome. However, reprogramming yields pluripotent stem cells that can differentiate into all cells that form a fetus, but not extraembryonic annexes. Therefore, a cellular model allowing study of placental development from a broad genomic repertoire is lacking.
Castel, Gaël, David, Laurent
openaire   +4 more sources

Localization of cathepsins D and B at the maternal-fetal interface and the invasiveness of the trophoblast during the postimplantation period in the mouse

, 2020
A survey of existing data suggests that trophoblast cells produce factors involved in extracellular matrix degradation. In this study, we correlated the expression of cathepsins D and B in the murine ectoplacental cone with the ultrastructural progress ...
Amarante-Paffaro, A. M., Yamada, A. T., Yokota, S., Joazeiro, P. P., Bevilacqua, E., Hoshida, M. S., Goncalves, C. R.   +6 more
core   +2 more sources

Multipotency of mouse trophoblast stem cells [PDF]

Stem Cell Research & Therapy, 2020
AbstractBackgroundIn a number of disease processes, the body is unable to repair injured tissue, promoting the need to develop strategies for tissue repair and regeneration, including the use of cellular therapeutics. Trophoblast stem cells (TSCs) are considered putative stem cells as they differentiate into other subtypes of trophoblast cells.
Minmin Hou, Junwen Han, Gu Li, Min-Young Kwon, Jiani Jiang, Sirisha Emani, Elizabeth S. Taglauer, Jin-Ah Park, Eun-Bee Choi, Munender Vodnala, Yick W. Fong, Sitaram M. Emani, Ivan O. Rosas, Mark A. Perrella, Xiaoli Liu   +14 more
openaire   +3 more sources