Oxidative stress stimulates alpha-tocopherol transfer protein in human trophoblast tumor cells BeWo [PDF]
, 2012 alpha-Tocopherol transfer protein (alpha-TTP) has been identified as the major intracellular transport protein for the antioxidant vitamin E (alpha-Tocopherol).
Etzl, Ronny P. +7 more
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What Is Trophoblast? A Combination of Criteria Define Human First-Trimester Trophoblast
Stem Cell Reports, 2016 Controversy surrounds reports describing the derivation of human trophoblast cells from placentas and embryonic stem cells (ESC), partly due to the difficulty in identifying markers that define cells as belonging to the trophoblast lineage.
Cheryl Q.E. Lee +8 more
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Natural Killer Cell Derived Microvesicles Affect the Function of Trophoblast Cells
Membranes, 2023 The interaction of natural killer (NK) and trophoblast cells underlies the formation of immune tolerance in the mother–fetus system and the maintenance of the physiological course of pregnancy.
Dmitry Sokolov +8 more
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Brucella abortus Infection of Placental Trophoblasts Triggers Endoplasmic Reticulum Stress-Mediated Cell Death and Fetal Loss via Type IV Secretion System-Dependent Activation of CHOP. [PDF]
, 2019 Subversion of endoplasmic reticulum (ER) function is a feature shared by multiple intracellular bacteria and viruses, and in many cases this disruption of cellular function activates pathways of the unfolded protein response (UPR).
Atluri, Vidya L +14 more
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Inhibition of Trophoblast-Induced Spiral Artery Remodeling Reduces Placental Perfusion in Rat Pregnancy. [PDF]
, 2010 Rats harboring the human angiotensinogen and human renin genes develop preeclamptic features in pregnancy. The preeclamptic rats exhibit a deeper trophoblast invasion associated with a reduced resistance index by uterine Doppler.
Cartwright, JE +12 more
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Isolation of Primary Mouse Trophoblast Cells and Trophoblast Invasion Assay [PDF]
Journal of Visualized Experiments, 2012 The placenta is responsible for the transport of nutrients, gasses and growth factors to the fetus, as well as the elimination of wastes. Thus, defects in placental development have important consequences for the fetus and mother, and are a major cause of embryonic lethality.
Kathleen A, Pennington +2 more
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Establishment of trophoblast stem cells under defined culture conditions in mice. [PDF]
PLoS ONE, 2014 The inner cell mass (ICM) and trophoblast cell lineages duet early embryonic development in mammals. After implantation, the ICM forms the embryo proper as well as some extraembryonic tissues, whereas the trophoectoderm (TE) exclusively forms the fetal ...
Yasuhide Ohinata, Tomoyuki Tsukiyama
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Gene expression analysis of bovine embryonic disc, trophoblast and parietal hypoblast at the start of gastrulation [PDF]
, 2017 In cattle early gastrulation-stage embryos (Stage 5), four tissues can be discerned: (i) the top layer of the embryonic disc consisting of embryonic ectoderm (EmE); (ii) the bottom layer of the disc consisting of mesoderm, endoderm and visceral hypoblast
Berg, D +3 more
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Impaired decidual natural killer cell regulation of vascular remodelling in early human pregnancies with high uterine artery resistance [PDF]
, 2012 During human pregnancy, natural killer (NK) cells accumulate in the maternal decidua, but their specific roles remain to be determined. Decidual NK (dNK) cells are present during trophoblast invasion and uterine spiral artery remodelling.
Cartwright, JE +6 more
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Regulation of major histocompatibility complex class II gene expression in trophoblast cells
Reproductive Biology and Endocrinology, 2004 Trophoblast cells are unique because they are one of the few mammalian cell types that do not express major histocompatibility complex (MHC) class II antigens, either constitutively or after exposure to IFN-γ.
Choi Jason C +2 more
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