Results 1 to 10 of about 17,936 (165)

Follistatin Is a Novel Chemoattractant for Migration and Invasion of Placental Trophoblasts of Mice

Cells, 2022
Follistatin (FST) as a gonadal protein is central to the establishment and maintenance of pregnancy. Trophoblasts’ migration and invasion into the endometrium are critical events in placental development.
Yan Qi, Xueling Cui, Zhonghui Liu
exaly   +3 more sources

Proinflammatory response of canine trophoblasts to Brucella canis infection [PDF]

PLoS ONE, 2017
Brucella canis infection is an important cause of late-term abortion in pregnant bitches. The pathophysiological mechanisms leading to B. canis-induced abortion are unknown, but heavily infected trophoblasts are consistently observed.
Mariana C Ferrero, CARLOS A Fossati, Pablo C Baldi   +2 more
exaly   +2 more sources

Chorionic villus-derived mesenchymal stem cell-mediated autophagy promotes the proliferation and invasiveness of trophoblasts under hypoxia by activating the JAK2/STAT3 signalling pathway

Cell & Bioscience, 2021
Background Trophoblast dysfunction during pregnancy is fundamentally involved in preeclampsia. Several studies have revealed that human chorionic villous mesenchymal stem cells (CV-MSCs) could regulate trophoblasts function.
Yijing Chu, Chengzhan Zhu, Chongyu Yue, Wei Peng, Weiping Chen, Guifang He, Changchang Liu, Yang Lv, Guoqiang Gao, Ke Yao, Rendong Han, Xiaoyu Hu, Yan Zhang, Yuanhua Ye   +13 more
doaj   +1 more source

Role of microRNAs in trophoblast invasion and spiral artery remodeling: Implications for preeclampsia

Frontiers in Cell and Developmental Biology, 2022
It is now well-established that microRNAs (miRNAs) are important regulators of gene expression. The role of miRNAs in placental development and trophoblast function is constantly expanding. Trophoblast invasion and their ability to remodel uterine spiral
Heyam Hayder, Yanan Shan, Yan Chen, Jacob Anderson O’Brien, Chun Peng, Chun Peng   +5 more
doaj   +1 more source

A High-Throughput Toxicity Screen of 42 Per- and Polyfluoroalkyl Substances (PFAS) and Functional Assessment of Migration and Gene Expression in Human Placental Trophoblast Cells

Frontiers in Toxicology, 2022
Per- and polyfluoroalkyl substances (PFAS) have become ubiquitous environmental contaminants that have been associated with adverse pregnancy outcomes in women and experimental research models.
Bevin E. Blake, Bevin E. Blake, Brittany P. Rickard, Suzanne E. Fenton   +3 more
doaj   +1 more source

Vertical Zika Virus Transmission at the Maternal-Fetal Interface

Frontiers in Virology, 2022
Zika virus (ZIKV) is spread by mosquito bites or via sexual or vertical transmission. ZIKV-infected adults are generally asymptomatic, but can display mild symptoms including fever, joint pain, rash and conjunctivitis. However, during pregnancy, vertical
Ozlem Guzeloglu-Kayisli, Umit Ali Kayisli, Frederick Schatz, Charles Joseph Lockwood   +3 more
doaj   +1 more source

ARHGEF18/p114RhoGEF Coordinates PKA/CREB Signaling and Actomyosin Remodeling to Promote Trophoblast Cell-Cell Fusion During Placenta Morphogenesis

Frontiers in Cell and Developmental Biology, 2021
Coordination of cell-cell adhesion, actomyosin dynamics and gene expression is crucial for morphogenetic processes underlying tissue and organ development. Rho GTPases are main regulators of the cytoskeleton and adhesion.
Robert Beal, Ana Alonso-Carriazo Fernandez, Dimitris K. Grammatopoulos, Dimitris K. Grammatopoulos, Karl Matter, Maria S. Balda   +5 more
doaj   +1 more source

TGF-β1 Promotes Zika Virus Infection in Immortalized Human First-Trimester Trophoblasts via the Smad Pathway

Cells, 2022
The Zika virus (ZIKV) is well known for causing congenital Zika syndrome if the infection occurs during pregnancy; however, the mechanism by which the virus infects and crosses the placenta barrier has not been completely understood. In pregnancy, TGF-β1
Quang Duy Trinh, Ngan Thi Kim Pham, Kazuhide Takada, Chika Takano, Shihoko Komine-Aizawa, Satoshi Hayakawa   +5 more
doaj   +1 more source

Crosstalk Between Trophoblasts and Decidual Immune Cells: The Cornerstone of Maternal-Fetal Immunotolerance

Frontiers in Immunology, 2021
The success of pregnancy relies on the fine adjustment of the maternal immune system to tolerate the allogeneic fetus. Trophoblasts carrying paternal antigens are the only fetal-derived cells that come into direct contact with the maternal immune cells ...
Ling Xu, Yanhong Li, Yifei Sang, Da-Jin Li, Meirong Du, Meirong Du   +5 more
doaj   +1 more source

Obesity and Maternal-Placental-Fetal Immunology and Health

Frontiers in Pediatrics, 2022
Obesity rates in women of childbearing age is now at 29%, according to recent CDC reports. It is known that obesity is associated with oxidative stress and inflammation, including disruptions in cellular function and cytokine levels.
Meredith Monaco-Brown, David A. Lawrence, David A. Lawrence   +2 more
doaj   +1 more source