Results 1 to 10 of about 30,805 (282)

Proinflammatory response of canine trophoblasts to Brucella canis infection. [PDF]

PLoS ONE, 2017
Brucella canis infection is an important cause of late-term abortion in pregnant bitches. The pathophysiological mechanisms leading to B. canis-induced abortion are unknown, but heavily infected trophoblasts are consistently observed.
Andrea G Fernández, M Soledad Hielpos, Mariana C Ferrero, Carlos A Fossati, Pablo C Baldi   +4 more
doaj   +4 more sources

Follistatin Is a Novel Chemoattractant for Migration and Invasion of Placental Trophoblasts of Mice

Cells, 2022
Follistatin (FST) as a gonadal protein is central to the establishment and maintenance of pregnancy. Trophoblasts’ migration and invasion into the endometrium are critical events in placental development.
Yan Qi, Xueling Cui, Zhonghui Liu
exaly   +3 more sources

Amnion-Derived Mesenchymal Stem Cell Exosomes-Mediated Autophagy Promotes the Survival of Trophoblasts Under Hypoxia Through mTOR Pathway by the Downregulation of EZH2

Frontiers in Cell and Developmental Biology, 2020
Human amnion-derived mesenchymal stem cells (AD-MSCs) have been reported as a promising effective treatment to repair tissue. Trophoblast dysfunction during pregnancy is significantly involved in the pathogenesis of preeclampsia (PE).
Yuanhua Ye, Ling Liu
exaly   +3 more sources

Reciprocal activation between M1 macrophages and trophoblasts through CXCL9/STAT1/ZEB1/CCL2 axis promotes recurrent spontaneous abortion [PDF]

Frontiers in Immunology
BackgroundThe crosstalk between macrophages and trophoblasts plays a crucial role in the development and progression of recurrent spontaneous abortion (RSA).
Sisi Yan, Xiang Wang, Qiuji Wu, Jinli Ding, Hui Qiu   +4 more
doaj   +2 more sources

Function of survivin in trophoblastic cells of the placenta [PDF]

, 2013
Background: Preeclampsia is one of the leading causes of maternal and perinatal mortality and morbidity worldwide and its pathogenesis is not totally understood.
Friemel, Alexandra, Kreis, Nina-Naomi, Louwen, Frank, Muschol-Steinmetz, Cornelia, Reinhard, Joscha, Yuan, Juping   +5 more
core   +14 more sources

Chorionic villus-derived mesenchymal stem cell-mediated autophagy promotes the proliferation and invasiveness of trophoblasts under hypoxia by activating the JAK2/STAT3 signalling pathway

Cell & Bioscience, 2021
Background Trophoblast dysfunction during pregnancy is fundamentally involved in preeclampsia. Several studies have revealed that human chorionic villous mesenchymal stem cells (CV-MSCs) could regulate trophoblasts function.
Yijing Chu, Chengzhan Zhu, Chongyu Yue, Wei Peng, Weiping Chen, Guifang He, Changchang Liu, Yang Lv, Guoqiang Gao, Ke Yao, Rendong Han, Xiaoyu Hu, Yan Zhang, Yuanhua Ye   +13 more
doaj   +1 more source

Role of microRNAs in trophoblast invasion and spiral artery remodeling: Implications for preeclampsia

Frontiers in Cell and Developmental Biology, 2022
It is now well-established that microRNAs (miRNAs) are important regulators of gene expression. The role of miRNAs in placental development and trophoblast function is constantly expanding. Trophoblast invasion and their ability to remodel uterine spiral
Heyam Hayder, Yanan Shan, Yan Chen, Jacob Anderson O’Brien, Chun Peng, Chun Peng   +5 more
doaj   +1 more source

A High-Throughput Toxicity Screen of 42 Per- and Polyfluoroalkyl Substances (PFAS) and Functional Assessment of Migration and Gene Expression in Human Placental Trophoblast Cells

Frontiers in Toxicology, 2022
Per- and polyfluoroalkyl substances (PFAS) have become ubiquitous environmental contaminants that have been associated with adverse pregnancy outcomes in women and experimental research models.
Bevin E. Blake, Bevin E. Blake, Brittany P. Rickard, Suzanne E. Fenton   +3 more
doaj   +1 more source

Trophoblast development [PDF]

REPRODUCTION, 2012
This review summarises current knowledge about the specification, commitment and maintenance of the trophoblast lineage in mice and cattle. Results from gene expression studies,in vivoloss-of-function models andin vitrosystems using trophoblast and embryonic stem cells have been assimilated into a model seeking to explain trophoblast ontogeny via gene ...
Peter L, Pfeffer, David J, Pearton
openaire   +2 more sources

Vertical Zika Virus Transmission at the Maternal-Fetal Interface

Frontiers in Virology, 2022
Zika virus (ZIKV) is spread by mosquito bites or via sexual or vertical transmission. ZIKV-infected adults are generally asymptomatic, but can display mild symptoms including fever, joint pain, rash and conjunctivitis. However, during pregnancy, vertical
Ozlem Guzeloglu-Kayisli, Umit Ali Kayisli, Frederick Schatz, Charles Joseph Lockwood   +3 more
doaj   +1 more source