Results 31 to 40 of about 21,207 (299)

Enhancement of Rubella Virus Infection in Immortalized Human First-Trimester Trophoblasts Under Low-Glucose Stress Conditions

Frontiers in Microbiology, 2022
Rubella virus (RuV) infections in pregnant women, especially first-trimester infections, can lead to congenital rubella syndrome (CRS). However, the mechanisms of fetal RuV infection are not completely understood, and it is not observed in every pregnant
Quang Duy Trinh, Kazuhide Takada, Ngan Thi Kim Pham, Chika Takano, Takahiro Namiki, Ryo Ikuta, Shingo Hayashida, Shoko Okitsu, Hiroshi Ushijima, Shihoko Komine-Aizawa, Satoshi Hayakawa   +10 more
doaj   +1 more source

The Trophoblast: A Rejoinder [PDF]

Science, 1904
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openaire   +2 more sources

Uterine spiral artery remodeling involves endothelial apoptosis induced by extravillous trophoblasts through Fas/FasL interactions.

, 2005
Objective— Invasion of uterine spiral arteries by extravillous trophoblasts in the first trimester of pregnancy results in loss of endothelial and musculoelastic layers.
Philip R. Dash, Cartwright, JE, Whitley, GS, Ashton, SV, Philip N. Baker, Crocker, IP, Baker, PN, Guy St. J. Whitley, Ian P. Crocker, Mark Wareing, Wareing, M, Sandra V. Ashton, Judith E. Cartwright, Dash, PR   +13 more
core   +1 more source

Delta‐9‐tetrahydrocannabinol disrupts mitochondrial function and attenuates syncytialization in human placental BeWo cells

Physiological Reports, 2020
The psychoactive component in cannabis, delta‐9‐tetrahydrocannabinol, can restrict fetal growth and development. Delta‐9‐tetrahydrocannabinol has been shown to negatively impact cellular proliferation and target organelles like the mitochondria resulting
O’Llenecia S. Walker, Rehginald Ragos, Harmeet Gurm, Mariah Lapierre, Linda L. May, Sandeep Raha   +5 more
doaj   +1 more source

Here and there a trophoblast, a transcriptional evaluation of trophoblast cell models

Cellular and Molecular Life Sciences, 2022
Abstract A recent explosion of methods to produce human trophoblasts and stem cells (hTSC) is fuelling a renewed interest in this tissue. The trophoblast is critical to reproduction by facilitating implantation, maternal physiological adaptations to pregnancy and the growth of the fetus through transport of nutrients between the mother and ...
Brian Joseph Cox, Kendra Naismith
openaire   +2 more sources

Identification of Epigenetic Factor Proteins Expressed in Human Embryonic Stem Cell-Derived Trophoblasts and in Human Placental Trophoblasts

, 2016
Human embryonic stem cells (hESCs) have been used to derive trophoblasts through differentiation in vitro. Intriguingly, mouse ESCs are prevented from differentiation to trophoblasts by certain epigenetic factor proteins such as Dnmt1, thus necessitating
Prasenjit Sarkar (2882255), Shan M. Randall (1590388), David C. Muddiman (143487), Balaji M. Rao (124516), Adam Mischler (2882252), Karen F. Dorman (2882258), Timothy S. Collier (2882264), Kim A. Boggess (2882261)   +7 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Inhibition of platelet aggregation by rat trophoblasts

, 2002
Objective: To determine the effect of rat trophoblast cell suspensions on adenosine diphosphate (ADP)-induced platelet aggregation. Materials and Methods: The trophoblasts were isolated from ectoplacental cones (a pre-placental tissue very rich in ...
Tewari, R., Singh, M. P., Dikshit, M., Mehrotra, P. K., Farheen, S.   +4 more
core   +1 more source

Malectin Alleviates Endoplasmic Reticulum Stress in Gestational Diabetes Mellitus via Glycoprotein Quality Control Mechanisms

Advanced Science, EarlyView.
Malectin alleviates high glucose‐induced ER stress and damage in placental trophoblasts, a function dependent on its six critical carbohydrate‐binding residues. In a GDM mouse model, administration of TAT‐Malectin ameliorated hyperglycemia and placental ER stress and prevented fetal macrosomia.
Jiahui Zhu, Yumeng Zhang, Ye Wang, Xiaoyu Zhu, Ailin Yuan, Weijing Yin, Huangmin Yu, Xuemin Pang, Yufeng He, Yuchen Wang, Tong Wang, Yong Li, Yunlong Si   +12 more
wiley   +1 more source

Similarities and differences in placental development between humans and cynomolgus monkeys

Reproductive Medicine and Biology, 2023
Background The placenta is an extraembryonic organ, which is essential to maintain a normal pregnancy. However, placental development in humans is poorly understood because of technical and ethical reasons. Methods We analyzed the anatomical localization
Shoma Matsumoto, Eiichi Okamura, Masanaga Muto, Masatsugu Ema   +3 more
doaj   +1 more source