Results 11 to 20 of about 21,207 (299)

Chorion laeve trophoblasts of preeclamptic fetal membranes: histochemically detectable enzyme activities do not change at a subcellular level

European Journal of Histochemistry, 2009
We examined the subcellular localization of ADPdegrading activity and cytochrome c oxidase (CCO) activity in chorion laeve trophoblasts from term and near term human fetal membranes, and compared them with those from severe preeclamptic fetal membranes ...
S Matsubara, T Takayama, R Iwasaki, A Izumi, T Watanabe, I Sato   +5 more
doaj   +3 more sources

Adipokine chemerin overexpression in trophoblasts leads to dyslipidemia in pregnant mice: implications for preeclampsia [PDF]

Lipids in Health and Disease, 2023
Background The adipokine chemerin regulates adipogenesis and the metabolic function of both adipocytes and liver. Chemerin is elevated in preeclamptic women, and overexpression of chemerin in placental trophoblasts induces preeclampsia-like symptoms in ...
Lunbo Tan, Zijun Ouyang, Zhilong Chen, Fen Sun, Haichun Guo, Feng Wang, Monique Mulder, Yuan Sun, Xifeng Lu, Jian V. Zhang, A. H. Jan Danser, Koen Verdonk, Xiujun Fan, Qing Yang   +13 more
doaj   +2 more sources

Trophoblast development [PDF]

Reproduction, 2012
Abstract This review summarises current knowledge about the specification, commitment and maintenance of the trophoblast lineage in mice and cattle. Results from gene expression studies, in vivo loss-of-function models and in vitro systems using trophoblast and embryonic stem cells have been assimilated into a model seeking to explain
Peter L, Pfeffer, David J, Pearton
openaire   +2 more sources

Engineering placenta‐like organoids containing endogenous vascular cells from human‐induced pluripotent stem cells

Bioengineering & Translational Medicine, 2023
The placenta is an essential organ that maintains the health of both the fetus and its mother. Understanding the development of human placenta has been hindered by the limitations of existing animal models and monolayer cell cultures.
Kangli Cui, Tingwei Chen, Yujuan Zhu, Yang Shi, Yaqiong Guo, Jianhua Qin   +5 more
doaj   +1 more source

Ezrin and Its Phosphorylated Thr567 Form Are Key Regulators of Human Extravillous Trophoblast Motility and Invasion

Cells, 2023
The protein ezrin has been shown to enhance cancer cell motility and invasion leading to malignant behaviours in solid tumours, but a similar regulatory function in the early physiological reproduction state is, however, much less clear.
Maral E. A. Tabrizi, Janesh K. Gupta, Stephane R. Gross   +2 more
doaj   +1 more source

The Expression and Localization of N-Myc Downstream-Regulated Gene 1 in Human Trophoblasts [PDF]

, 2013
The protein N-Myc downstream-regulated gene 1 (NDRG1) is implicated in the regulation of cell proliferation, differentiation, and cellular stress response.
Shi, Xiao-Hua, Shi, XH, Jacob C. Larkin, Baosheng Chen, Xiao-Hua Shi (2286394), Larkin Jacob C., Larkin, Jacob C., Yoel Sadovsky, Baosheng Chen (294603), Larkin, JC, Chuang, Eric Y., Jacob C Larkin, Chen Baosheng, Sadovsky, Y, Shi Xiao-Hua, Chen, Baosheng, Sadovsky, Yoel, Sadovsky Yoel, Yoel Sadovsky (199874), Jacob C. Larkin (459267), Chen, B, Xiao-Hua Shi, Larkin, Jacob C   +22 more
core   +1 more source

Human amniotic fluid glycoproteins expressing sialyl Lewis carbohydrate antigens stimulate progesterone production in human trophoblasts in vitro [PDF]

, 2004
Background: Progesterone is thought to mediate immune modulator effects by regulating uterine responsiveness. The aim of the study was to clarify the effect of transferrin and glycodelin A (former name PP14) as sialyl Lewis X-expressing glycoproteins on ...
Streu, Annett, Richter, Dagmar-Ulrike, Volker Briese, Jeschke, Udo, Klaus Friese, Ioannis Mylonas, Annett Streu, Udo Jeschke, Briese, Volker, Mylonas, Ioannis, Müller, Heiner, Dagmar-Ulrike Richter, Friese, Klaus, Heiner Müller   +13 more
core   +1 more source

TMBIM4 Deficiency Facilitates NLRP3 Inflammasome Activation-Induced Pyroptosis of Trophoblasts: A Potential Pathogenesis of Preeclampsia

Biology, 2023
Impaired invasion of EVTs results in inadequate remodelling of arteries and poor placentation, leading to PE. TMBIM4 was found to promote the migration and invasion of human osteosarcoma U2-OS and breast cancer MCF7 cell lines.
Yuanyao Chen, Lin Xiao, Guoqiang Sun, Min Li, Hailan Yang, Zhangyin Ming, Kai Zhao, Xuejun Shang, Huiping Zhang, Chunyan Liu   +9 more
doaj   +1 more source

Interferon gamma is involved in apoptosis of trophoblast cells at the maternal–fetal interface following Toxoplasma gondii infection

International Journal of Infectious Diseases, 2015
Objective: To assess whether interferon gamma (IFN-γ) secreted by decidual natural killer (dNK) cells at the maternal–fetal interface is involved in the apoptosis of trophoblast cells (trophoblasts) following Toxoplasma gondii infection.
Ling Zhang, Mingdong Zhao, Fang Jiao, Xiaoyan Xu, Xianbing Liu, Yuzhu Jiang, Haixia Zhang, Xiaoxuan Ou, Xuemei Hu   +8 more
doaj   +1 more source

Regulation of trophoblast beta1-integrin expression by contact with endothelial cells

Cell Communication and Signaling, 2004
Background In human and non-human primates, migratory trophoblasts penetrate the uterine epithelium, invade uterine matrix, and enter the uterine vasculature. Invasive trophoblasts show increased expression of β1 integrin.
Thirkill Twanda L, Hendren Sonia R, Soghomonians Arlen, Mariano Natalie F, Barakat Abdul I, Douglas Gordon C   +5 more
doaj   +1 more source