Results 21 to 30 of about 74,627 (274)

Establishment of Bovine Trophoblast Stem Cells

Cell Reports, 2022
AbstractHere we report that a chemical cocktail (LCDM: hLIF,CHIR99021,DiM andMiH) previously used for extended potential pluripotent stem cells enables the de novo derivation and long-term culture of bovine trophoblast stem cells (TSCs). Bovine TSCs exhibit transcriptomic and epigenetic features characteristic of trophectoderm cells from bovine embryos
Yinjuan Wang, Leqian Yu, Jie Li, Linkai Zhu, Hao Ming, Carlos Pinzon Arteaga, Hai-Xi Sun, Jun Wu, Zongliang Jiang   +8 more
openaire   +2 more sources

Stimulation of hCG protein and mRNA in first trimester villous cytotrophoblast cells in vitro by glycodelin A [PDF]

, 2005
Aim: Human chorionic gonadotropin (hCG) is produced by fetal trophoblast cells and secreted into maternal circulation mainly in the first trimester of pregnancy.
Albanese, Bergemann, Boime, Bonduelle, Cole, Hammer, Heffner, Jeschke, Julkunen, Julkunen, Kubota, Laird, Laird, Maston, Okamoto, Pestell, Pierro, Pockley, Pockley, Seppala   +19 more
core   +1 more source

Fosl1 overexpression directly activates trophoblast-specific gene expression programs in embryonic stem cells

Stem Cell Research, 2018
During early development in placental mammals, proper trophoblast lineage development is essential for implantation and placentation. Defects in this lineage can cause early pregnancy failures and other pregnancy disorders. However, transcription factors
Bum-Kyu Lee, Nadima Uprety, Yu Jin Jang, Scott K. Tucker, Catherine Rhee, Lucy LeBlanc, Samuel Beck, Jonghwan Kim   +7 more
doaj   +1 more source

CXCL12/CXCR4 axis triggers the activation of EGF receptor and ERK signaling pathway in CsA-induced proliferation of human trophoblast cells. [PDF]

PLoS ONE, 2012
INTRODUCTION: Our previous study has demonstrated Cyclosporin A (CsA) promotes the proliferation of human trophoblast cells. Therefore, we further investigate the intracellular signaling pathway involved in the CsA-induced proliferation of human ...
Hong-Bo Zhao, Chuan-Ling Tang, Yan-Li Hou, Li-Rong Xue, Ming-Qing Li, Mei-Rong Du, Da-Jin Li   +6 more
doaj   +1 more source

Human amniotic fluid glycoproteins expressing sialyl Lewis carbohydrate antigens stimulate progesterone production in human trophoblasts in vitro [PDF]

, 2004
Background: Progesterone is thought to mediate immune modulator effects by regulating uterine responsiveness. The aim of the study was to clarify the effect of transferrin and glycodelin A (former name PP14) as sialyl Lewis X-expressing glycoproteins on ...
Annett Streu, Beer AE, Crosignani PG, Dagmar-Ulrike Richter, Heiner Müller, Ioannis Mylonas, Jeschke U, Julkunen M, Julkunen M, Julkunen M, Klaus Friese, Kliman HJ, Loh TT, Mandler RN, Martinovic S, Mylonas I, Okamoto N, Seki H, Shanker YG, Siiteri PK, Starreveld JS, Udo Jeschke, Vanderpuye OA, Volker Briese, Zelewski L   +24 more
core   +1 more source

Fetal-derived trophoblast use the apoptotic cytokine tumor necrosis factor-alpha-related apoptosis-inducing ligand to induce smooth muscle cell death. [PDF]

, 2007
Remodeling of the uterine spiral arteries during pregnancy transforms them from high to low resistance vessels that lack vasoconstrictive properties. This process is essential to meet the demand for increased blood flow imposed by the growing fetus. Loss
Aplin, JD, Baker, PN, Cartwright, JE, Freeman, A, Harris, LK, Keogh, RJ, Whitley, GS   +6 more
core   +1 more source

Trophoblast lineage-specific differentiation and associated alterations in preeclampsia and fetal growth restriction. [PDF]

, 2020
The human placenta is a poorly-understood organ, but one that is critical for proper development and growth of the fetus in-utero. The epithelial cell type that contributes to primary placental functions is called "trophoblast," including two main ...
Farah, Omar, Nguyen, Calvin, Parast, Mana M, Tekkatte, Chandana   +3 more
core   +2 more sources

Differential migration and activation profile of monocytes after trophoblast interaction. [PDF]

PLoS ONE, 2014
Macrophages at the maternal-placental interface coordinate opposite demands under the control of trophoblast cells such as the response against pathogens on one hand, and apoptotic cell clearance and wound healing with the production of suppressor ...
Esteban Grasso, Daniel Paparini, Vanesa Hauk, Gabriela Salamone, Claudia Perez Leiros, Rosanna Ramhorst   +5 more
doaj   +1 more source

Adhesive and degradative properties of human placental cytotrophoblast cells in vitro. [PDF]

, 1989
Human fetal development depends on the embryo rapidly gaining access to the maternal circulation. The trophoblast cells that form the fetal portion of the human placenta have solved this problem by transiently exhibiting certain tumor-like properties ...
Cui, TY, Damsky, CH, Fisher, SJ, Grahl, K, Hartman, L, Tarpey, J, Zhang, GY, Zhang, L   +7 more
core   +3 more sources

NK cells, hypoxia and trophoblast cell differentiation [PDF]

Cell Cycle, 2012
Hemochorial placentation is characterized by extensive remodeling of the maternal vasculature, converting them to flaccid low resistance vessels. This process greatly facilitates exchange of nutrients and gases between the mother and the fetus. Two key modulators that orchestrate these vascular changes have been identified at the maternal fetal ...
Damayanti, Chakraborty, M A Karim, Rumi, Michael J, Soares   +2 more
openaire   +2 more sources