Results 21 to 30 of about 44,286 (241)

Isolation of Primary Mouse Trophoblast Cells and Trophoblast Invasion Assay [PDF]

Journal of Visualized Experiments, 2012
The placenta is responsible for the transport of nutrients, gasses and growth factors to the fetus, as well as the elimination of wastes. Thus, defects in placental development have important consequences for the fetus and mother, and are a major cause of embryonic lethality.
Kathleen A, Pennington, Jessica M, Schlitt, Laura C, Schulz   +2 more
openaire   +2 more sources

CXCL12/CXCR4 axis triggers the activation of EGF receptor and ERK signaling pathway in CsA-induced proliferation of human trophoblast cells. [PDF]

PLoS ONE, 2012
INTRODUCTION: Our previous study has demonstrated Cyclosporin A (CsA) promotes the proliferation of human trophoblast cells. Therefore, we further investigate the intracellular signaling pathway involved in the CsA-induced proliferation of human ...
Hong-Bo Zhao, Chuan-Ling Tang, Yan-Li Hou, Li-Rong Xue, Ming-Qing Li, Mei-Rong Du, Da-Jin Li   +6 more
doaj   +1 more source

Differential migration and activation profile of monocytes after trophoblast interaction. [PDF]

PLoS ONE, 2014
Macrophages at the maternal-placental interface coordinate opposite demands under the control of trophoblast cells such as the response against pathogens on one hand, and apoptotic cell clearance and wound healing with the production of suppressor ...
Esteban Grasso, Daniel Paparini, Vanesa Hauk, Gabriela Salamone, Claudia Perez Leiros, Rosanna Ramhorst   +5 more
doaj   +1 more source

What Is Trophoblast? A Combination of Criteria Define Human First-Trimester Trophoblast

Stem Cell Reports, 2016
Controversy surrounds reports describing the derivation of human trophoblast cells from placentas and embryonic stem cells (ESC), partly due to the difficulty in identifying markers that define cells as belonging to the trophoblast lineage.
Cheryl Q.E. Lee, Lucy Gardner, Margherita Turco, Nancy Zhao, Matthew J. Murray, Nicholas Coleman, Janet Rossant, Myriam Hemberger, Ashley Moffett   +8 more
doaj   +1 more source

The trophoblast giant cells of cricetid rodents [PDF]

Frontiers in Cell and Developmental Biology, 2023
Giant cells are a prominent feature of placentation in cricetid rodents. Once thought to be maternal in origin, they are now known to be trophoblast giant cells (TGCs). The large size of cricetid TGCs and their nuclei reflects a high degree of polyploidy. While some TGCs are found at fixed locations, others migrate throughout the placenta and deep into
Favaron, Phelipe O., Carter, Anthony M.
openaire   +3 more sources

Natural Killer Cell Derived Microvesicles Affect the Function of Trophoblast Cells

Membranes, 2023
The interaction of natural killer (NK) and trophoblast cells underlies the formation of immune tolerance in the mother–fetus system and the maintenance of the physiological course of pregnancy.
Dmitry Sokolov, Alina Gorshkova, Kseniia Markova, Yulia Milyutina, Kseniya Pyatygina, Maria Zementova, Andrey Korenevsky, Valentina Mikhailova, Sergey Selkov   +8 more
doaj   +1 more source

Function of survivin in trophoblastic cells of the placenta [PDF]

Placenta, 2013
Preeclampsia is one of the leading causes of maternal and perinatal mortality and morbidity worldwide and its pathogenesis is not totally understood. As a member of the chromosomal passenger complex and an inhibitor of apoptosis, survivin is a well-characterized oncoprotein.
Muschol-Steinmetz, Cornelia, Friemel, Alexandra, Kreis, Nina-Naomi, Reinhard, Joscha, Yuan, Juping, Louwen, Frank   +5 more
openaire   +5 more sources

A defective CXCL16/CXCR6 axis increases the risk of pregnancy loss via the abnormal crosstalk between decidual γδ t cells and trophoblasts

Reproductive and Developmental Medicine, 2021
Objective: The maternal–fetal interface undergoes dynamic changes to allow the fetus to grow and develop in the uterus. The interaction between decidual γδ Τ cells and trophoblasts plays a pivotal role during successful pregnancy; however, their ...
Deng-Xuan Fan, Ming-Qing Li, Wen-Jie Zhou, Hong-Lan Huang, Hui-Li Yang, Cong-Jian Xu   +5 more
doaj   +1 more source

Regulation of major histocompatibility complex class II gene expression in trophoblast cells

Reproductive Biology and Endocrinology, 2004
Trophoblast cells are unique because they are one of the few mammalian cell types that do not express major histocompatibility complex (MHC) class II antigens, either constitutively or after exposure to IFN-γ.
Choi Jason C, Murphy Shawn P, Holtz Renae   +2 more
doaj   +1 more source

Establishment of trophoblast stem cells under defined culture conditions in mice. [PDF]

PLoS ONE, 2014
The inner cell mass (ICM) and trophoblast cell lineages duet early embryonic development in mammals. After implantation, the ICM forms the embryo proper as well as some extraembryonic tissues, whereas the trophoectoderm (TE) exclusively forms the fetal ...
Yasuhide Ohinata, Tomoyuki Tsukiyama
doaj   +1 more source