Results 41 to 50 of about 88,307 (280)

Inhibition of LAMP3 mediates the protective effect of vitamin D against hypoxia/reoxygenation in trophoblast cells

Brazilian Journal of Medical and Biological Research, 2023
Inadequate invasion and excessive apoptosis of trophoblast cells are associated with the development of preeclampsia. Vitamin D deficiency in pregnant women may lead to an increased risk of preeclampsia.
Xiaoyu Tian, Lili Zheng, Jing Ma, Ying Xu, Yulin Zhang, Yalei Pi   +5 more
doaj   +1 more source

Expression of CD82 in human trophoblast and its role in trophoblast invasion. [PDF]

PLoS ONE, 2012
BACKGROUND: Well-controlled trophoblast invasion at maternal-fetal interface is a critical event for the normal development of placenta. CD82 is a member of transmembrane 4 superfamily, which showed important role in inhibiting tumor cell invasion and ...
Qian Zhang, Dongmei Tan, Wenping Luo, Junjie Lu, Yi Tan   +4 more
doaj   +1 more source

Analysis of Oct4-dependent transcriptional networks regulating self-renewal and pluripotency in human embryonic stem cells [PDF]

, 2006
The POU domain transcription factor OCT4 is a key regulator of pluripotency in the early mammalian embryo and is highly expressed in the inner cell mass of the blastocyst. Consistent with its essential role in maintaining pluripotency, Oct4 expression is
Adjaye, J., Babaie, Y., Brink, T., Burdon, T., Greber, B., Groth, D., Herwig, R., Lehrach, H., Wruck, W.   +8 more
core   +2 more sources

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Nested Selves: Self‐Organization and Shared Markov Blankets in Prenatal Development in Humans

Topics in Cognitive Science, EarlyView., 2023
Abstract The immune system is a central component of organismic function in humans. This paper addresses self‐organization of biological systems in relation to—and nested within—other biological systems in pregnancy. Pregnancy constitutes a fundamental state for human embodiment and a key step in the evolution and conservation of our species. While not
Anna Ciaunica, Michael Levin, Fernando E. Rosas, Karl Friston   +3 more
wiley   +1 more source

Obesogenic Diet in Mice Leads to Inflammation and Oxidative Stress in the Mother in Association with Sex-Specific Changes in Fetal Development, Inflammatory Markers and Placental Transcriptome

Antioxidants
Background: Obesity during pregnancy is related to adverse maternal and neonatal outcomes. Factors involved in these outcomes may include increased maternal insulin resistance, inflammation, oxidative stress, and nutrient mishandling. The placenta is the
Alejandro A. Candia, Samantha C. Lean, Cindy X. W. Zhang, Daniel R. McKeating, Anna Cochrane, Edina Gulacsi, Emilio A. Herrera, Bernardo J. Krause, Amanda N. Sferruzzi-Perri   +8 more
doaj   +1 more source

Trans-differentiation of trophoblast stem cells: implications in placental biology

Life Science Alliance, 2023
Formation of trophendothelial cells is associated with trophoblast differentiation and is regulated by HES1. Trophoblast differentiation–induced TRAIL secretion directs preferential demise of ECs located in their vicinity, aiding trophoblast vasculogenic
Madhurima Paul, Shreeta Chakraborty, Safirul Islam, Rupasri Ain   +3 more
doaj   +1 more source

A method for isolating and culturing placental cells from failed early equine pregnancies [PDF]

, 2016
Early pregnancy loss occurs in 6–10% of equine pregnancies making it the main cause of reproductive wastage. Despite this, reasons for the losses are known in only 16% of cases.
A.J. McGladdery, A.M. de Mestre, Allen, B.V. Rose, C. Smith, Cabrera-Sharp, D.C. Wathes, de Mestre, Diskin, F.E. Barrelet, Greenwold, H. Neal, Hamstead, I.J. Cameron, Inskeep, J. Crowhurst, J. Pynn, J.R. Crabtree, K.L.P. Verheyen, Lanoix, M.J. Firth, O.D. Pynn, Oriol, Petracchi, Raudsepp, Robbin, S. Bate, Seo, Strand, V. Cabrera-Sharp, Vanderwall, Z. Wise   +31 more
core   +2 more sources

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Conserved gene expression patterns in the placenta underlie pregnancy complications associated with hypoxia in mice and humans

Cellular and Molecular Life Sciences
During pregnancy hypoxia leads to complications like fetal growth restriction (FGR). Maternal inhalation hypoxia during late murine pregnancy impairs placental phenotype and fetal development in a severity-dependent manner.
Emma J Siragher, Josephine S Higgins, Owen R Vaughan, Abigail L Fowden, Amanda N Sferruzzi-Perri   +4 more
doaj   +1 more source