Results 51 to 60 of about 51,241 (234)

Exposure‐Response Analyses of Datopotamab Deruxtecan (Dato‐DXd), a TROP2‐Directed Antibody‐Drug Conjugate, in Advanced Non‐small Cell Lung Cancer

Clinical Pharmacology &Therapeutics, EarlyView.
Exposure‐response analyses supported a favorable benefit‐risk profile of Dato‐DXd at 6 mg/kg Q3W in patients with advanced nonsquamous NSCLC. Datopotamab deruxtecan (Dato‐DXd) is a trophoblast cell‐surface antigen‐2 (TROP2)‐directed antibody‐drug conjugate (ADC) that has demonstrated clinical activity in patients with NSCLC who have received prior ...
Ying Hong, Anna M. Mc Laughlin, Yuzhuo Pan, Sofia Friberg Hietala, Sophie Peigné, Michael Chargualaf, Zoey Tang, Diansong Zhou, Naoyuki Tajima, Malaz Abutarif, Tushar Garimella   +10 more
wiley   +1 more source

Impact of donor mare and stallion identity on the likelihood of pregnancy after transfer of in vitro produced embryos

Equine Veterinary Journal, EarlyView.
Abstract Background The success of in vitro embryo production (IVEP) is influenced by donor mare and stallion. Objectives To determine whether donor mare and stallion influence the pregnancy rate after transfer of in vitro produced (IVP) blastocysts and to identify factors influencing the likelihood of obtaining one or more pregnancies from a single ...
M. Papas, T. A. E. Stout, J. C. M. Vernooij, B. Leemans, L. Arnold, M. M. Beitsma, L. I. Wijnands, M. de Ruijter‐Villani, S. Colleoni, G. Lazzari, C. Galli, A. Claes   +11 more
wiley   +1 more source

Vascular dysfunction in women with recurrent pregnancy loss: Possible association with antiphospholipid antibodies

International Journal of Gynecology &Obstetrics, Volume 169, Issue 1, Page 206-214, April 2025.
Abstract Objective Antiphospholipid antibodies (aPL) are recognized to have a pivotal role in recurrent pregnancy loss (RPL) and cardiovascular disease. Therefore, we assessed the vascular function of women with RPL and examined the association with each type of aPL.
Titi Yang, Emi Okada, Maho Todoroki, Siyu Liu, Rukmali Athurupana, Kumie Kataoka, Chiaki Kashino, Takashi Mitsui, Toru Hasegawa, Yasuhiko Kamada, Hisashi Masuyama, Mikiya Nakatsuka   +11 more
wiley   +1 more source

Nested Selves: Self‐Organization and Shared Markov Blankets in Prenatal Development in Humans

Topics in Cognitive Science, EarlyView., 2023
Abstract The immune system is a central component of organismic function in humans. This paper addresses self‐organization of biological systems in relation to—and nested within—other biological systems in pregnancy. Pregnancy constitutes a fundamental state for human embodiment and a key step in the evolution and conservation of our species. While not
Anna Ciaunica, Michael Levin, Fernando E. Rosas, Karl Friston   +3 more
wiley   +1 more source

The utility of serum markers in the conservative management of placenta accreta spectrum (PAS) by leaving the placenta in situ in women with high‐grade PAS

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective To investigate the association between serum markers and successful conservative management of patients with placenta accreta spectrum (PAS). Methods This was a retrospective case–control study where patients with high‐grade PAS between 2011 and 2025 undergoing conservative leaving the placenta in situ were included.
Ammar Al Naimi, Charlotte Wiesmann, Doerthe Brueggmann, Anna Elisabeth Hentrich, Eileen Deuster, Samira Catharina Hoock, Lukas Jennewein, Frank Louwen   +7 more
wiley   +1 more source

Protocol for the derivation and culture of murine trophoblast organoids for CRISPR-Cas9 screening

STAR Protocols
Summary: Murine trophoblast organoids present a more balanced array of trophoblast subtypes, rendering them a suitable platform for CRISPR-Cas9-based screening.
Qian Mao, Jingwei Jiang, Qinying Ye, Haopeng Wang, Chao-Po Lin   +4 more
doaj   +1 more source

The effectiveness of a training program in improving the prenatal diagnosis accuracy of placenta accreta spectrum with ultrasound

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective This study evaluates the effectiveness of a structured training program in improving prenatal ultrasound diagnostic accuracy for placenta accreta spectrum (PAS) and assesses trainees' ability to recognize individual ultrasound markers of PAS.
Nicha Vetvitayavatana, Pharuhas Chanprapaph, Julaporn Pooliam   +2 more
wiley   +1 more source

KRT18 regulates trophoblast cell migration and invasion which are essential for embryo implantation

Reproductive Biology and Endocrinology, 2023
Female infertility is a worldwide concern that impacts the quality of life and well-being of affected couples. Failure of embryo implantation is a major cause of early pregnancy loss and is precisely regulated by a programmed molecular mechanism.
Xiaoling Liang, Xiaoxiao Qiu, Yana Ma, Wenzhi Xu, Sijia Chen, Peipei Zhang, Mengying Liu, Xiaona Lin   +7 more
doaj   +1 more source

Reassessing the role of antiphospholipid antibodies in placental‐mediated adverse pregnancy outcomes in systemic lupus erythematosus: A retrospective cohort study

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective To examine how different antiphospholipid antibody (aPL) profiles influence placental‐mediated adverse pregnancy outcomes (APOs) in women with systemic lupus erythematosus (SLE). Methods This retrospective cohort study included 245 pregnant women with SLE and 490 controls from a single center.
Meng Jiang, Yanling Chang, Ning Zhang, Wen Di, Jiayue Wu   +4 more
wiley   +1 more source

The role of large language models as screening assistants in the diagnosis of placenta accreta spectrum pathologies

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective Large language models (LLMs) are increasingly utilized in modern medicine. In obstetrics, their ability to interpret complex imaging, such as ultrasound images for placenta accreta spectrum (PAS), remains largely unexplored. This study aimed to investigate the capacity of multimodal LLMs to interpret sonographic images of placentae ...
Iason Psilopatis, Heidrun Schoenberger, Annkatrin Butenschoen, Thabea K. Musik, Georgia Levidou, Beatrice Mosimann, Gwendolin Manegold‐Brauer   +6 more
wiley   +1 more source