Results 71 to 80 of about 60,792 (295)

Protocol for the derivation and culture of murine trophoblast organoids for CRISPR-Cas9 screening

STAR Protocols
Summary: Murine trophoblast organoids present a more balanced array of trophoblast subtypes, rendering them a suitable platform for CRISPR-Cas9-based screening.
Qian Mao, Jingwei Jiang, Qinying Ye, Haopeng Wang, Chao-Po Lin   +4 more
doaj   +1 more source

Vascular dysfunction in women with recurrent pregnancy loss: Possible association with antiphospholipid antibodies

International Journal of Gynecology &Obstetrics, Volume 169, Issue 1, Page 206-214, April 2025.
Abstract Objective Antiphospholipid antibodies (aPL) are recognized to have a pivotal role in recurrent pregnancy loss (RPL) and cardiovascular disease. Therefore, we assessed the vascular function of women with RPL and examined the association with each type of aPL.
Titi Yang, Emi Okada, Maho Todoroki, Siyu Liu, Rukmali Athurupana, Kumie Kataoka, Chiaki Kashino, Takashi Mitsui, Toru Hasegawa, Yasuhiko Kamada, Hisashi Masuyama, Mikiya Nakatsuka   +11 more
wiley   +1 more source

Inhibitor of DNA Binding Protein 2 (ID2) Mediates the Anti-Proliferative and Pro-Differentiation Effects of Insulin-like Growth Factor-1 (IGF-1)

Life
In preeclampsia (PE), impaired trophoblast proliferation and differentiation are thought to cause abnormal placentation and subsequent clinical manifestations of the disease, i.e., hypertension, proteinuria, and end-organ damage.
Rebecca Ssengonzi, Yuye Wang, Jiayi Zhou, Yukako Kayashima, W. H. Davin Townley-Tilson, Balaji Rao, Qing Ma, Nobuyo Maeda-Smithies, Feng Li   +8 more
doaj   +1 more source

Alkaloid leonurine exerts anti‐inflammatory effects via modulating MST1 expression in trophoblast cells

Immunity, Inflammation and Disease, 2021
Background Pre‐eclampsia (PE) is mainly attributed to the inflammation of trophoblast cells in pregnant women, which results in damage to the maternal organs and growth retardation of the fetus.
Fang Zong, Yingzi Zhao
doaj   +1 more source

Crim1 has an essential role in glycogen trophoblast cell and sinusoidal-trophoblast giant cell development in the placenta

, 2012
Normal placental development and function is essential for fetal growth of eutherian mammals. Mutational studies have shown that numerous growth factors'are required for placental development and differentiation of placental lineages.
Chiu, H. S., Chiu, H.S., Little, M.H., Pennisi, D. J., Simmons, D. G., Kinna, G., Little, M. H., Simmons, D.G., Wilkinson, L.   +8 more
core   +1 more source

The utility of serum markers in the conservative management of placenta accreta spectrum (PAS) by leaving the placenta in situ in women with high‐grade PAS

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective To investigate the association between serum markers and successful conservative management of patients with placenta accreta spectrum (PAS). Methods This was a retrospective case–control study where patients with high‐grade PAS between 2011 and 2025 undergoing conservative leaving the placenta in situ were included.
Ammar Al Naimi, Charlotte Wiesmann, Doerthe Brueggmann, Anna Elisabeth Hentrich, Eileen Deuster, Samira Catharina Hoock, Lukas Jennewein, Frank Louwen   +7 more
wiley   +1 more source

SUMO-specific protease 2 is essential for modulating p53-Mdm2 in development of trophoblast stem cell niches and lineages. [PDF]

PLoS Biology, 2008
SUMO-specific protease 2 (SENP2) modifies proteins by removing SUMO from its substrates. Although SUMO-specific proteases are known to reverse sumoylation in many defined systems, their importance in mammalian development and pathogenesis remains largely
Shang-Yi Chiu, Naoya Asai, Frank Costantini, Wei Hsu   +3 more
doaj   +1 more source

Reassessing the role of antiphospholipid antibodies in placental‐mediated adverse pregnancy outcomes in systemic lupus erythematosus: A retrospective cohort study

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective To examine how different antiphospholipid antibody (aPL) profiles influence placental‐mediated adverse pregnancy outcomes (APOs) in women with systemic lupus erythematosus (SLE). Methods This retrospective cohort study included 245 pregnant women with SLE and 490 controls from a single center.
Meng Jiang, Yanling Chang, Ning Zhang, Wen Di, Jiayue Wu   +4 more
wiley   +1 more source

Ovine trophoblast is a primary source of TNFα during Chlamydophila abortus infection

, 2009
Chlamydophila abortus is a Gram-negative obligate intracellular bacterium that causes infectious abortion in sheep (ovine enzootic abortion, OEA) and humans.
Jepson, Catherine, Maley, Stephen, Wheelhouse, Nick, James Stanton, Gary Entrican, Buxton, David, Tim Baszler, David Buxton, David Longbottom, Longbottom, David, Stanton, James, Baszler, Tim, Watson, Donna, Nick Wheelhouse, Entrican, Gary, David Deane, Catherine Jepson, Sean Wattegedera, Stephen Maley, Donna Watson, Wattegedera, Sean, Deane, David   +21 more
core   +1 more source

Decidual macrophage‐mediated ferroptosis in trophoblasts leads to recurrent spontaneous abortion

iMeta, EarlyView.
Decidual macrophages from recurrent spontaneous abortion (RSA) patients promote trophoblast ferroptosis and impair trophoblast cell function. Mechanistically, the CXCL2/NF‐κB/HMOX1 axis mediates this effect. Conversely, trophoblasts co‐cultured with RSA decidual macrophages induce pro‐inflammatory macrophage polarization through IL‐6/JAK2/STAT3 ...
Xin Chen, Xueqin Ma, Pengcheng Pang, Heng Zhou, Ruohan Li, Yan He, Yan Zhang, Jing Yang, Qianlin Song, Qingsong Ye   +9 more
wiley   +1 more source