Results 71 to 80 of about 49,121 (248)

Trophoblast tales [PDF]

Reproductive BioMedicine Online, 2012
Martin H, Johnson, Jacques, Cohen, Gedis, Grudzinskas   +2 more
openaire   +2 more sources

Analysis of High‐Risk Factors for Failure of Bleeding Control in Enhanced Myometrial Vascularity Treated With Uterine Artery Embolization

Journal of Clinical Ultrasound, EarlyView.
Enhanced Myometrial Vascularity (EMV) is a serious gynecological condition that often leads to abnormal uterine bleeding. Malformation size and involvement of the uterine fundus are significant risk factors. If EMV diameter > 3.85 cm, the bleeding of the patient is more likely to result in failure in UAE treatment.
Linhua Zhu, Yongfang Yue, Lili Cao
wiley   +1 more source

TFAP2C is a key regulator of intrauterine trophoblast cell invasion and deep hemochorial placentation

JCI Insight
Transcription factor AP-2 gamma (TFAP2C) has been identified as a key regulator of the trophoblast cell lineage and hemochorial placentation. The rat possesses deep placentation characterized by extensive intrauterine trophoblast cell invasion, which ...
Esteban M. Dominguez, Ayelen Moreno-Irusta, Regan L. Scott, Khursheed Iqbal, Michael J. Soares   +4 more
doaj   +1 more source

Novel role for PI3Kβ in placental function through regulation of system A amino acid transporter expression, associated with embryonic lethality

Cellular and Molecular Life Sciences
The placenta is essential for embryonic development, in part by mediating nutrient transfer from mother to embryo. Placental insufficiency is the most common cause of intrauterine growth restriction which has long-term health consequences lasting into ...
Sarah E. Conduit, Cindy X. W. Zhang, Wayne Pearce, Julie Guillermet-Guibert, Amanda N. Sferruzzi-Perri, Bart Vanhaesebroeck   +5 more
doaj   +1 more source

Alterations in MicroRNA and Cytokine Expressions in Placental and Amniotic Tissues of COVID‐19 Affected Pregnant Women

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Since 2019, coronavirus disease 2019 (COVID‐19) has been associated with increased risks of preterm birth and placental complications. We prospectively investigated alterations in microRNAs (miRNAs) and cytokines in placental and amniotic tissues from pregnant women with and without COVID‐19 to evaluate the infection's impact on pregnancy ...
Wei‐Chun Chen, Shu‐Yu Hu, Chao‐Min Cheng, Ching‐Ju Shen   +3 more
wiley   +1 more source

Hemophilia A: An Ideal Disease for Prenatal Therapy

Prenatal Diagnosis, EarlyView.
ABSTRACT Hemophilia A (HA) is the most common inherited coagulation defect. Current state‐of‐the‐art treatment consists of frequent administration of prophylactic infusions of coagulation factor VIII (FVIII) protein or bispecific antibodies that replace the cofactor function of FVIIIa to maintain hemostasis. However, these treatments are far from ideal,
Christopher D. Porada, Anthony Atala, Graça Almeida‐Porada   +2 more
wiley   +1 more source

In Utero HSC Transplantation for Sickle Cell Disease: A Potential Therapeutic Approach That Overcomes Complications of Current Therapies

Prenatal Diagnosis, EarlyView.
ABSTRACT Sickle cell disease (SCD) affects millions worldwide but has limited treatment options, most of which carry significant side effects. At present, the only curative treatment for SCD is allogeneic or gene‐modified autologous hematopoietic stem cell (HSC) transplantation (Tx).
Oluwaseun O. Babatunde, Madeleine G. Bibby, Anthony Atala, Graça Almeida‐Porada, Christopher D. Porada   +4 more
wiley   +1 more source

Novel and High‐Throughput Method of Isolating Single Fetal Cells Using FACS for NIPT

Prenatal Diagnosis, EarlyView.
ABSTRACT Objective To evaluate fluorescence activated cell sorting (FACS) as a method of single‐cell isolation of rare circulating fetal cells from maternal blood for use in cell‐based non‐invasive prenatal testing (cbNIPT). Method Blood samples (30 mL) were collected from 75 ‘low‐risk’ pregnant women (gestational age 10–15 weeks).
Ripudaman Singh, Bolette Hestbek Nicolaisen, Mathias Kølvraa, Inga Baasch Christensen, Mads Tang Dalsgaard, Lars Henning Pedersen, Niels Uldbjerg, Ida Vogel, Lotte Hatt, Katarina Ravn   +9 more
wiley   +1 more source

Progesterone receptor antagonism by mifepristone impairs trophoblast stemness and promotes apoptosis through upregulation of PDCD4

Cell & Bioscience
Background Trophoblast cells are a critical component of retained products of conception (RPOC). While mifepristone is widely used as a non-invasive treatment for RPOC, its precise molecular mechanisms in trophoblast regulation remain poorly defined ...
Jie Zhou, Li Yan, Yamei Li, Suming Huang, Qicheng Lan, Duo Zhang, Qian Zhu, Xiaoya Zhao, Jian Zhang   +8 more
doaj   +1 more source

Mirror Syndrome (Ballantyne Syndrome): Prenatal Diagnosis, Pathophysiology, and the Role of Fetal Therapy—A Narrative Review

Prenatal Diagnosis, EarlyView.
ABSTRACT Mirror syndrome is a rare maternal–fetal condition associated with fetal hydrops and a high risk of adverse maternal and fetal perinatal outcomes. Its diagnosis is challenging due to the lack of standardized diagnostic criteria and its clinical and biochemical overlap with preeclampsia.
Riccardo Tudisco, Pauline Latapie, Anita Romiti, Alexandra Benachi, Maelig Abgral, Alexandre J. Vivanti   +5 more
wiley   +1 more source