Results 91 to 100 of about 60,792 (295)

In Utero HSC Transplantation for Sickle Cell Disease: A Potential Therapeutic Approach That Overcomes Complications of Current Therapies

Prenatal Diagnosis, EarlyView.
ABSTRACT Sickle cell disease (SCD) affects millions worldwide but has limited treatment options, most of which carry significant side effects. At present, the only curative treatment for SCD is allogeneic or gene‐modified autologous hematopoietic stem cell (HSC) transplantation (Tx).
Oluwaseun O. Babatunde, Madeleine G. Bibby, Anthony Atala, Graça Almeida‐Porada, Christopher D. Porada   +4 more
wiley   +1 more source

TFAP2C is a key regulator of intrauterine trophoblast cell invasion and deep hemochorial placentation

JCI Insight
Transcription factor AP-2 gamma (TFAP2C) has been identified as a key regulator of the trophoblast cell lineage and hemochorial placentation. The rat possesses deep placentation characterized by extensive intrauterine trophoblast cell invasion, which ...
Esteban M. Dominguez, Ayelen Moreno-Irusta, Regan L. Scott, Khursheed Iqbal, Michael J. Soares   +4 more
doaj   +1 more source

Trophoblast tales [PDF]

Reproductive BioMedicine Online, 2012
Martin H, Johnson, Jacques, Cohen, Gedis, Grudzinskas   +2 more
openaire   +2 more sources

Phosphatidylinositol 3 kinase modulation of trophoblast cell differentiation [PDF]

, 2010
Background The trophoblast lineage arises as the first differentiation event during embryogenesis. Trophoblast giant cells are one of several end-stage products of trophoblast cell differentiation in rodents.
Michael J Soares, Lindsey N. Kent, Michael J. Soares, Konno, Toshihiro, Soares, Michael J., Lindsey N Kent, Kent, Lindsey N., Toshihiro Konno   +7 more
core   +1 more source

Exploring the Reproductive Toxicity of Bisphenol S Through a Network Toxicology and Molecular Docking Analysis

Pediatric Discovery, EarlyView.
Utilizing network toxicology, molecular docking, and dynamic simulations to investigate the potential reproductive toxicity of bisphenol S (BPS). ABSTRACT The aim of this study was to investigate the potential reproductive toxicity of bisphenol S (BPS) and the related molecular mechanisms through a network toxicology approach.
Siyuan Wang, Yan Fu, Xu Huang, Qitong Guo, Xiangqin Zheng, Shengde Wu, Lianju Shen, Guanghui Wei   +7 more
wiley   +1 more source

Single-Cell Analysis Identifies Thymic Maturation Delay in Growth-Restricted Neonatal Mice

Frontiers in Immunology, 2018
Fetal growth restriction (FGR) causes a wide variety of defects in the neonate which can lead to increased risk of heart disease, diabetes, anxiety and other disorders later in life.
Wendi A. Bacon, Wendi A. Bacon, Wendi A. Bacon, Russell S. Hamilton, Russell S. Hamilton, Ziyi Yu, Jens Kieckbusch, Jens Kieckbusch, Delia Hawkes, Ada M. Krzak, Chris Abell, Francesco Colucci, Francesco Colucci, D. Stephen Charnock-Jones, D. Stephen Charnock-Jones   +14 more
doaj   +1 more source

Gestational related morphological abnormalities in placental villous trophoblast turnover in compromised pregnancies

, 2009
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Human placental villi are covered by a layer of trophoblast epithelia in direct contact with maternal blood, which exist in a constant steady-state of ...
Widdows, Kate Louise
core  

MUC1 is involved in trophoblast transendothelial migration

, 2007
The factors that regulate trophoblast invasion of the uterine vasculature are incompletely understood. In this paper we show that macaque trophoblasts express the mucin, MUC1, and that it is involved in trophoblast-endothelial interaction ...
Stout, Michael, Cao, Tim, Thirkill, Twanda L., Barakat, Abdul, Douglas, Gordon C., Blankenship, Thomas N.   +5 more
core   +1 more source

Diflubenzuron Caused Mitochondrial Dysfunction, Ca2+ Homeostasis Disruption, and Intrinsic Apoptosis in Trophoblastic Cells

Environmental Toxicology, EarlyView.
ABSTRACT Diflubenzuron is used as an insect growth inhibitor, and its potential risk to human health was raised owing to the possibility of environmental residues and human exposure. This study aimed to investigate the toxic mechanism of diflubenzuron on trophoblastic cells such as HTR8/SVneo and JEG‐3 cells. We investigated mitochondrial function, Ca2+
Miji Kim, Wonhyoung Park, Whasun Lim, Gwonhwa Song, Sunwoo Park   +4 more
wiley   +1 more source

Novel role for PI3Kβ in placental function through regulation of system A amino acid transporter expression, associated with embryonic lethality

Cellular and Molecular Life Sciences
The placenta is essential for embryonic development, in part by mediating nutrient transfer from mother to embryo. Placental insufficiency is the most common cause of intrauterine growth restriction which has long-term health consequences lasting into ...
Sarah E. Conduit, Cindy X. W. Zhang, Wayne Pearce, Julie Guillermet-Guibert, Amanda N. Sferruzzi-Perri, Bart Vanhaesebroeck   +5 more
doaj   +1 more source