Results 11 to 20 of about 88,307 (280)
REPRODUCTION, 2012 This review summarises current knowledge about the specification, commitment and maintenance of the trophoblast lineage in mice and cattle. Results from gene expression studies,in vivoloss-of-function models andin vitrosystems using trophoblast and embryonic stem cells have been assimilated into a model seeking to explain trophoblast ontogeny via gene ...
Peter L, Pfeffer, David J, Pearton
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Modeling human trophoblast, the placental epithelium at the maternal fetal interface. [PDF]
, 2020 Appropriate human trophoblast lineage specification and differentiation is crucial for the establishment of normal placentation and maintenance of pregnancy. However, due to the lack of proper modeling systems, the molecular mechanisms of these processes
Bui, Tony +3 more
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Cells, 2023 Adverse maternal environments such as small size, malnutrition, and metabolic conditions are known to influence fetal growth outcomes. Similarly, fetal growth and metabolic alterations may alter the intrauterine environment and affect all fetuses in ...
Esteban Salazar-Petres +3 more
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Menstrual flow as a non-invasive source of endometrial organoids
Communications Biology, 2021 Tereza Cindrova-Davies et al. present a method for deriving endometrial organoids using menstrual flow collected from women. The approach shows promise as a personalised and non-invasive way to investigate gynaecological conditions such as endometriosis ...
Tereza Cindrova-Davies +6 more
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Trophoblast lineage-specific differentiation and associated alterations in preeclampsia and fetal growth restriction. [PDF]
, 2020 The human placenta is a poorly-understood organ, but one that is critical for proper development and growth of the fetus in-utero. The epithelial cell type that contributes to primary placental functions is called "trophoblast," including two main ...
Farah, Omar +3 more
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Nature Communications, 2023 The extravillous trophoblast cell lineage is a key feature of placentation and successful pregnancy. Knowledge of transcriptional regulation driving extravillous trophoblast cell development is limited.
Kaela M. Varberg +17 more
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iScience, 2023 Summary: Placental hormones orchestrate maternal metabolic adaptations to support pregnancy. We hypothesized that placental ER stress, which characterizes early-onset pre-eclampsia (ePE), compromises glycosylation, reducing hormone bioactivity and these ...
Hong Wa Yung +13 more
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Kisspeptin regulation of genes involved in cell invasion and angiogenesis in first trimester human trophoblast cells. [PDF]
PLoS ONE, 2014 The precise regulation of extravillous trophoblast invasion of the uterine wall is a key process in successful pregnancies. Kisspeptin (KP) has been shown to inhibit cancer cell metastasis and placental trophoblast cell migration.
Víctor A Francis +4 more
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How Do Uterine Natural Killer and Innate Lymphoid Cells Contribute to Successful Pregnancy?
Frontiers in Immunology, 2021 Innate lymphoid cells (ILCs) are the most abundant immune cells in the uterine mucosa both before and during pregnancy. Circumstantial evidence suggests they play important roles in regulating placental development but exactly how they contribute to the ...
Oisín Huhn +10 more
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Inhibition of Trophoblast-Induced Spiral Artery Remodeling Reduces Placental Perfusion in Rat Pregnancy. [PDF]
, 2010 Rats harboring the human angiotensinogen and human renin genes develop preeclamptic features in pregnancy. The preeclamptic rats exhibit a deeper trophoblast invasion associated with a reduced resistance index by uterine Doppler.
Cartwright, JE +12 more
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