Results 11 to 20 of about 51,241 (234)

CHD8-Dependent Chromatin Licensing Sustains Trophoblast Stem Cell Transcriptional Programs. [PDF]

Adv Sci (Weinh)
In this study, Huang et al., identify chromatin remodeler CHD8 as an essential factor in TSC maintenance and placental development. CHD8‐dependent chromatin accessibility supports the occupancy of key trophoblast TFs and is coupled to KMT2A‐associated H3K4me3 deposition at TSC stem and cell cycle genes, providing a permissive chromatin environment for ...
Huang Y, Hu Z, Liao J, Huang L, Liu J, Tu C, Li Y, Xie L, Bi S, Fang X, Chen J, Du L, Sun W, Wang H, Zhang S, Chen D, Tu Z.   +16 more
europepmc   +2 more sources

Trophoblast development [PDF]

Reproduction, 2012
Abstract This review summarises current knowledge about the specification, commitment and maintenance of the trophoblast lineage in mice and cattle. Results from gene expression studies, in vivo loss-of-function models and in vitro systems using trophoblast and embryonic stem cells have been assimilated into a model seeking to explain
Peter L, Pfeffer, David J, Pearton
openaire   +2 more sources

Menstrual flow as a non-invasive source of endometrial organoids

Communications Biology, 2021
Tereza Cindrova-Davies et al. present a method for deriving endometrial organoids using menstrual flow collected from women. The approach shows promise as a personalised and non-invasive way to investigate gynaecological conditions such as endometriosis ...
Tereza Cindrova-Davies, Xiaohui Zhao, Kay Elder, Carolyn J. P. Jones, Ashley Moffett, Graham J. Burton, Margherita Y. Turco   +6 more
doaj   +1 more source

NSUN2-Mediated m⁵C Modification of TGFB1 in Trophoblasts Remodels Macrophage Function to Prevent URSA. [PDF]

Adv Sci (Weinh)
NSUN2 and m5C decline in URSA villous tissues. Trophoblast Nsun2 ablation disrupts macrophage‐mediated maternal‐fetal tolerance and triggers embryo resorption. Mechanistically, NSUN2‐YBX1 axis stabilizes m5C‐modified TGFB1 mRNA to maintain TGF‐β1 secretion and M2 polarization, and restoring this signaling rescues maternal‐fetal immune tolerance to ...
Zhu X, Liu X, Yu X, Han Q, Shi F, Song W, Liu L, Chu C, Shen C, Zhang Z, Li X.   +10 more
europepmc   +2 more sources

Derivation of Mouse Dome-Shaped Trophoblast Stem Cells With Low Heterogeneity From Blastocysts. [PDF]

Cell Prolif
Here, Liu et al. report the generation of mouse dome‐shaped trophoblast stem cells (dTSCs) with low heterogeneity and autonomous differentiation potential. dTSCs robustly generate all trophoblast lineages in vitro and contribute to the placenta in vivo, providing a refined model for studying trophoblast development and related disorders.
Liu M, Ren S, Xia X, Lu G, Yang H, Zheng Y, Zhao J, Zhao XY, Wang M.   +8 more
europepmc   +2 more sources

Perturbation of placental protein glycosylation by endoplasmic reticulum stress promotes maladaptation of maternal hepatic glucose metabolism

iScience, 2023
Summary: Placental hormones orchestrate maternal metabolic adaptations to support pregnancy. We hypothesized that placental ER stress, which characterizes early-onset pre-eclampsia (ePE), compromises glycosylation, reducing hormone bioactivity and these ...
Hong Wa Yung, Xiaohui Zhao, Luke Glover, Charlotte Burrin, Poh-Choo Pang, Carolyn J.P. Jones, Carolyn Gill, Kate Duhig, Matts Olovsson, Lucy C. Chappell, Stuart M. Haslam, Anne Dell, Graham J. Burton, D. Stephen Charnock-Jones   +13 more
doaj   +1 more source

How Do Uterine Natural Killer and Innate Lymphoid Cells Contribute to Successful Pregnancy?

Frontiers in Immunology, 2021
Innate lymphoid cells (ILCs) are the most abundant immune cells in the uterine mucosa both before and during pregnancy. Circumstantial evidence suggests they play important roles in regulating placental development but exactly how they contribute to the ...
Oisín Huhn, Oisín Huhn, Xiaohui Zhao, Laura Esposito, Laura Esposito, Ashley Moffett, Ashley Moffett, Francesco Colucci, Francesco Colucci, Andrew M. Sharkey, Andrew M. Sharkey   +10 more
doaj   +1 more source

Extravillous trophoblast cell lineage development is associated with active remodeling of the chromatin landscape

Nature Communications, 2023
The extravillous trophoblast cell lineage is a key feature of placentation and successful pregnancy. Knowledge of transcriptional regulation driving extravillous trophoblast cell development is limited.
Kaela M. Varberg, Esteban M. Dominguez, Boryana Koseva, Joseph M. Varberg, Ross P. McNally, Ayelen Moreno-Irusta, Emily R. Wesley, Khursheed Iqbal, Warren A. Cheung, Carl Schwendinger-Schreck, Craig Smail, Hiroaki Okae, Takahiro Arima, Michael Lydic, Kristin Holoch, Courtney Marsh, Michael J. Soares, Elin Grundberg   +17 more
doaj   +1 more source

Hyperactivated Wnt-β-catenin signaling in the absence of sFRP1 and sFRP5 disrupts trophoblast differentiation through repression of Ascl2

BMC Biology, 2020
Background Wnt signaling is a critical determinant for the maintenance and differentiation of stem/progenitor cells, including trophoblast stem cells during placental development.
Haili Bao, Dong Liu, Yingchun Xu, Yang Sun, Change Mu, Yongqin Yu, Chunping Wang, Qian Han, Sanmei Liu, Han Cai, Fan Liu, Shuangbo Kong, Wenbo Deng, Bin Cao, Haibin Wang, Qiang Wang, Jinhua Lu   +16 more
doaj   +1 more source

Kisspeptin regulation of genes involved in cell invasion and angiogenesis in first trimester human trophoblast cells. [PDF]

PLoS ONE, 2014
The precise regulation of extravillous trophoblast invasion of the uterine wall is a key process in successful pregnancies. Kisspeptin (KP) has been shown to inhibit cancer cell metastasis and placental trophoblast cell migration.
Víctor A Francis, Aron B Abera, Mushi Matjila, Robert P Millar, Arieh A Katz   +4 more
doaj   +1 more source