Results 51 to 60 of about 32,908 (297)

Unique Eomes+ NK Cell Subsets Are Present in Uterus and Decidua During Early Pregnancy

Frontiers in Immunology, 2016
Decidual and uterine natural killer (NK) cells have been shown to contribute to the successful pregnancy both in humans and mice. NK cells represent “cytotoxic” group 1 innate lymphoid cells (ILCs) and are distinct from the recently described “helper ...
E. Montaldo, P. Vacca, L. Chiossone, D. Croxatto, Fabrizio Loiacono, S. Martini, S. Ferrero, T. Walzer, L. Moretta, M. Mingari   +9 more
semanticscholar   +1 more source

Visualizing Dynamic Changes at the Maternal-Fetal Interface Throughout Human Pregnancy by Mass Cytometry

Frontiers in Immunology, 2020
During healthy pregnancy, a balanced microenvironment at the maternal-fetal interface with coordinated interaction between various immune cells is necessary to maintain immunological tolerance.
Anita van der Zwan, Vincent van Unen, Vincent van Unen, Guillaume Beyrend, Sandra Laban, Carin van der Keur, Hanneke J. M. Kapsenberg, Thomas Höllt, Thomas Höllt, Susana M. Chuva de Sousa Lopes, Marie-Louise P. van der Hoorn, Frits Koning, Frans H. J. Claas, Michael Eikmans, Sebastiaan Heidt   +14 more
doaj   +1 more source

Ectopic decidua of the appendix: a case report

Surgical Case Reports, 2021
Background Ectopic decidua is the presence of decidual tissue outside the uterus. Ectopic decidua of the appendix is a rare entity that can present with abdominal symptoms mimicking appendicitis.
Manabu Kaneko, Hiroaki Nozawa, Hirofumi Rokutan, Koji Murono, Tetsuo Ushiku, Soichiro Ishihara   +5 more
doaj   +1 more source

New Insights into Atonic Postpartum Hemorrhage: Animal Model Construction Based on Placental Nanodelivery Systems

Advanced Healthcare Materials, EarlyView.
This study develops a placenta‐targeted nanodelivery system co‐loading HMGB1 protein and the NLRP3 agonist nigericin to establish an animal model of atonic postpartum hemorrhage. The model accurately recapitulates clinical phenotypes, including prolonged labor and uterine contractility dysfunction, while revealing inflammatory activation in placental ...
Jiangxue Qu, Ruiqi Wu, Hai Jiang, Lian Chen, Yingying Tian, Shuai Zeng, Tongmin Liu, Cheng Zhao, Huifeng Shi, Xiaolong Liang, Yangyu Zhao   +10 more
wiley   +1 more source

Single cell transcriptional signatures of the human placenta in term and preterm parturition

eLife, 2019
More than 135 million births occur each year; yet, the molecular underpinnings of human parturition in gestational tissues, and in particular the placenta, are still poorly understood. The placenta is a complex heterogeneous organ including cells of both
Roger Pique-Regi, Roberto Romero, Adi L Tarca, Edward D Sendler, Yi Xu, Valeria Garcia-Flores, Yaozhu Leng, Francesca Luca, Sonia S Hassan, Nardhy Gomez-Lopez   +9 more
doaj   +1 more source

Bisphenol B Exposure Induces Miscarriage by Suppressing Migration/Invasion and Migrasome Formation

Advanced Science, EarlyView.
BPB (Bisphenol B) exposure up‐regulates ER (estrogen receptor) levels, enhances its interactions with the lnc‐HZ04 promoter region, and thus promotes ER‐mediated lnc‐HZ04 transcription. Subsequently, lnc‐HZ04 suppresses TCF4 (transcription factor 4)‐mediated PKCA (protein kinase C alpha) transcription and subsequently suppresses migration/invasion and ...
Wenxin Huang, Manli Wang, Yi Sun, Xiaoping Yue, Xun Li, Yanbing Lin, Geng Guo, Depeng Zhao, Qigang Fan, Xiaoling Ma, Zhihong Zhang, Shuaishuai Xing, Xiaoting Shen, Huidong Zhang   +13 more
wiley   +1 more source

HLA-G in human early pregnancy: Control of uterine immune cell activation and likely

Biomedical Journal, 2015
Despite a number of controversies, the functional importance of human leukocyte antigen G (HLA-G) in early human pregnancy is now sustained by a large amount of sound data.
Philippe Le Bouteiller
doaj   +1 more source

How Do Uterine Natural Killer and Innate Lymphoid Cells Contribute to Successful Pregnancy?

Frontiers in Immunology, 2021
Innate lymphoid cells (ILCs) are the most abundant immune cells in the uterine mucosa both before and during pregnancy. Circumstantial evidence suggests they play important roles in regulating placental development but exactly how they contribute to the ...
Oisín Huhn, Oisín Huhn, Xiaohui Zhao, Laura Esposito, Laura Esposito, Ashley Moffett, Ashley Moffett, Francesco Colucci, Francesco Colucci, Andrew M. Sharkey, Andrew M. Sharkey   +10 more
doaj   +1 more source

Natural Cytotoxicity Receptors in Decidua Natural Killer Cells of Term Normal Pregnancy

Journal of Pregnancy, 2018
Aim To investigate the changes in the maternal immune system at term pregnancy, we studied the expression of natural cytotoxicity receptors (NCRs) and the cytokine production of NK cells in term placenta decidua and peripheral blood. Methods Term decidua
Hideki Takahashi, Tatsuo Yamamoto, M. Yamazaki, T. Murase, T. Matsuno, F. Chishima   +5 more
semanticscholar   +1 more source

Hyperandrogenemia Induces Trophoblast Ferroptosis and Early Pregnancy Loss in Patients With PCOS via CMA‐Dependent FTH1 Degradation

Advanced Science, EarlyView.
In PCOS patients with hyperandrogenemia, decreased ferritin heavy chain 1 (FTH1) causes Fe2⁺ overload and ferroptosis in trophoblasts. Androgens induce FTH1 protein degradation via AR‐LAMP2A‐mediated chaperone‐mediated autophagy pathway, leading to placental development disruption and early pregnancy loss. Metformin mitigates androgen‐induced placental
Hanjing Zhou, Weijie Yang, Na Liu, Qing Liu, Jiamin Jin, Chenqiong Zhao, Xiaoying Jin, Miao Gui, Haiyan Zhu, Songying Zhang, Yinli Zhang   +10 more
wiley   +1 more source