Results 151 to 160 of about 15,781,096 (290)

Behaviour artificial intelligence technology to support the decision-making process of continuation or withdrawal of life-sustaining therapy. [PDF]

Intensive Care Med Exp
Thoral PJ, de Metz J, Mulia S, Ten Broeke A, Heyning N, Ten Tusscher BL, Gigengack RK, Feijen HM, Chorus CG, van den Bogaard B, Elbers PWG.   +10 more
europepmc   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Parental Decision-Making Process in Termination of Pregnancy for Congenital Heart Disease: From the Multidisciplinary Perinatal Council of a Turkish Tertiary Center. [PDF]

Diagnostics (Basel)
Oktem A, Ceylan M, Golbasi H.
europepmc   +1 more source

A Decision-Support Tool for Choosing Between Alternative Payment Models for Multispecialty Group Practices

, 2014
Purpose: In Austria, the existing payment mechanism for ambulatory health care has a strong fee-for-service component. Due to legal requirements, however, Austrian sickness funds have to implement a new payment system with a focus on lump sum payment for
Pfeffer, N., Popper, Nikolas, Jung, Reinhard, Einzinger, Patrick   +3 more
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Strategic Decision-Making in Small Firms: Towards a Taxonomy of Entrepreneurial Decision-Makers [PDF]

Most changes in firms take place after a decision has been made. Despite that small firms are no exception to this, previous research into decision-making processes have left this subject uncharted.
Petra Gibcus, Jeroen de Jong, Patrick Vermeulen   +2 more
core  

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Understanding the kidney replacement therapy decision-making process. [PDF]

BMC Nephrol
Prakash S, Vangala S, Razvi K, Taylor MH, Drury E, D'Alfonso M, Oliveira I, Le TH, Veazie P, McIntosh S.   +9 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Decision-Making Process of Healthcare Providers Regarding Catheterization Method: A Nationwide Survey Study. [PDF]

Neurourol Urodyn
Christiaans CHH, van Veen FEE, Scheepe JR, Blok BFM.   +3 more
europepmc   +1 more source