Results 181 to 190 of about 2,185,301 (307)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Interactive, Personalized Patient Decision Aid for COVID-19 Vaccination in Canada: User-Centered Design Approach.

JMIR Hum Factors
Etienne D, Archambault PM, Bogoch II, Chambers CT, Chittle AD, Demers J, Driedger SM, Dubé È, Gagnon MP, Gavaruzzi T, Giguère A, Grandvaux N, Grindrod K, Hakim H, Jeimy S, Kindrachuk J, LeBlanc A, MacDonald SE, Ndjaboue R, Noubi M, Orji R, Paquette JS, Parent E, Renaud JS, Sander B, Taljaard M, Tannenbaum Greenberg D, Tremblay MC, Vohra-Miller S, Welch VA, Witteman HO.   +30 more
europepmc   +1 more source

Patient Perspectives Toward a Decision Aid for Radioactive Iodine Treatment for Intermediate Risk Thyroid Cancer. [PDF]

Int J Behav Med
Carr AL, Gabriel KL, Pillai G, Pocchia J, Graves KD, Jonklaas J.   +5 more
europepmc   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Effect of an in-consult patient decision aid on decisional quality and involvement for patients with severe hip or knee osteoarthritis: a multicenter, cluster randomized controlled trial. [PDF]

Acta Orthop
Pedersen TA, Lindberg-Larsen M, Jensen CM, Steffensen KD, Varnum C.   +4 more
europepmc   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

"The Doctor Helped Me Decide": A Linguistic Analysis of Contraceptive Shared Decision-Making Narratives in Clinical Encounters Supported by a Decision Aid Mobile Application. [PDF]

Perspect Med Educ
Witkop CT, Maggio LA, Konopasky A.
europepmc   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Development of a Decision Aid to Support Shared Decision-Making on Cannabis Use for Arthritis: Protocol for a Multiphase Study.

JMIR Res Protoc
Aref HAT, Al Hamarneh YN, Kiang TKL, Yacyshyn E, Sadowski CA.   +4 more
europepmc   +1 more source

The development of a decision aid to support treatment choice in pelvic organ prolapse: a Delphi study. [PDF]

BMC Med Inform Decis Mak
Drost LE, Stegeman M, van Dijk J, Lamers RED, The R, Gerritse MBE, Franx A, Vos MC.   +7 more
europepmc   +1 more source