Results 111 to 120 of about 65,002 (306)
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Graphical representation of global water models [PDF]
Geoscientific Model DevelopmentNumerical models are simplified representations of the real world at a finite level of complexity. Global water models are used to simulate the terrestrial part of the global water cycle, and their outputs contribute to the evaluation of important ...
H. Müller Schmied +41 more
doaj +1 more source
Reasoning with ordered binary decision diagrams
Discrete Applied Mathematics, 2000 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Takashi Horiyama, Toshihide Ibaraki
openaire +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Journal of Computer Science and Technology, 2007 This paper proposes a model that predicts the complexity of Boolean functions with only XOR/XNOR min-terms using back propagation neural networks (BPNNs) applied to Binary Decision Diagrams (BDDs). The BPNN model (BPNNM) is developed through the training
Ali Assi +3 more
doaj
Reconstruction of the transformer theory
MATEC Web of Conferences, 2018 The fallacy of the traditional transformer theory is illustrated. The fundamentals of the new theory, beginning from principle of the transformer action, motion of electromagnetic field in its window, new equivalent circuit and vector diagrams are ...
Shakirov Mansur
doaj +1 more source
Parallel Combinatorial Optimization with Decision Diagrams
, 2014 . We propose a new approach for parallelizing search for com-binatorial optimization that is based on a recursive application of approx-imate Decision Diagrams.
Horst Samulowitz +5 more
core +1 more source
Assessing the Effect of Visualizations on Bayesian Reasoning through Crowdsourcing [PDF]
, 2012 People have difficulty understanding statistical information and are unaware of their wrong judgments, particularly in Bayesian reasoning. Psychology studies suggest that the way Bayesian problems are represented can impact comprehension, but few visual ...
Dragicevic, Pierre +2 more
core +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source