Results 151 to 160 of about 65,002 (306)
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
IEEE AccessComputerized adaptive testing (CAT) presents a tradeoff dilemma involving item exposure bias and measurement accuracy. To resolve this dilemma, we propose a new two-step CAT mechanism to balance exposure bias and measurement accuracy.
Maomi Ueno +3 more
doaj +1 more source
Dynamic Minimization of Word-Level Decision Diagrams
, 1998 Word-Level Decision Diagrams (WLDDs), like *BMDs and K*BMDs, have recently been introduced as a data structure for verification. The size of WLDDs largely depends on the chosen variable ordering, i.e.
Rolf Drechsler +3 more
core +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Probabilistic Sentential Decision Diagrams.
, 2014 sponsorship: ONR grant #N00014-12-1-0423 NSF grant #IIS-1118122 Research Foundation-Flanders (FWO-Vlaanderen)
Kisa, Doga +3 more
openaire +2 more sources
Lagrangian Bounds from Decision Diagrams
, 2015 Relaxed decision diagrams have recently been used in constraint programming to improve constraint propagation and optimization reasoning. In most applications, however, a decision diagram is compiled with respect to a single combinatorial structure.
Cire, Andre A. +5 more
core +1 more source
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source