Author response to Zupan et al., Letter to the editor regarding "Intracranial hemorrhage after ischemic stroke in patients on direct oral anticoagulants: results from a prospective observational study" by Purrucker et al. [PDF]
Neurol Res PractPurrucker J +5 more
europepmc +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Is body mass index a sufficient marker in spine pain prognostication? [PDF]
Interv Pain MedSamnani L.
europepmc +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Reconciling Value Conflicts in Regional Forest Planning in Australia: A Decision Theoretic Approach
The Regional Forest Agreement (RFA) programme introduced in the 1990s, in Australia to protect environmental values, encourage job creation and growth and manage forests in an ecologically sustainable manner.
Herath, Gamini, Ananda, Jayanath
core
Surgical implications of CT-based emphysema scoring in predicting prolonged air leak-defining its role as a risk stratification tool rather than a decision trigger. [PDF]
J Thorac DisWang J, Guo H.
europepmc +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Adult-onset nephroblastoma in a male patient: a case report. [PDF]
AME Case RepMahenthiran AK, Abedali ZA, Rice KR.
europepmc +1 more source
Ideological implications of translation decisions
, 1998 Aquest article presenta un seguit de consideracions sobre la manera com determinades solucions a l'hora de traduir termes institucionals influencien la visió que la cultura d'arribada pugui tenir de les institucions a què es fa referència, i per extensió de la cultura a la qual pertanyen.
openaire +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source