Results 151 to 160 of about 2,826,372 (331)

Decision support systems [PDF]

open access: yes
Decision Support Systems (DSS) are a specific class of computerized information system that supports business and organizational decision-making activities.
Georgiana MARIN
core  

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

open access: yesFEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani   +6 more
wiley   +1 more source

Joint Determination of Internal Organizational Design: Decision-Making, Task Allocation, and Incentive Scheme, [PDF]

open access: yes
This paper studies the issue of designing an optimal organizational form: design for sub-units' task allocation, decision-making structure, and incentive schemes for organizational members.
Keunkwan Ryu, Son Ku Kim
core  

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

open access: yesFEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

Consensus Decision-Making and its Possibilities in Libraries

open access: yesIn the Library with the Lead Pipe, 2012
Introduction Since Occupy Wall Street finally started getting mainstream media coverage, the idea of consensus decision-making seems to have permeated our American psyche.
Emily Ford
doaj  

ORGANIZATIONAL CRISES AND DECISION MAKING

open access: yes, 2011
Henrique Martinelli sempre sonhou em tornar a sua pequena empresa uma referência na produção de vinhos. Porém, a organização apresentava algumas deficiências, como a falta de tecnologia, baixa capacitação dos colaboradores e dificuldades de distribuição dos produtos, sendo que estes fatores não permitiam que o sonho se tornasse realidade. Além disso, o
Genari, Denise   +3 more
openaire   +1 more source

Firms, Nonprofits, and Cooperatives: A Theory of Organizational Choice [PDF]

open access: yes
This paper formalizes the difference between firms, nonprofits, and cooperatives and identifies optimal organizational choice. In a model of quality provision, we find a clear ranking of quality produced: Firms provide lowest and nonprofits highest ...
Herbst, P., Prüfer, J.
core   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

open access: yesFEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li   +8 more
wiley   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

open access: yesFEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand   +2 more
wiley   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

open access: yesAging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef   +2 more
wiley   +1 more source

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