Results 141 to 150 of about 2,454,117 (316)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The Health Care Decision-Making Process Framework

, 2010
Health care decision making is a process that includes definable steps in a desirable sequence. The process is universally relevant (i.e., it applies in all settings) and enduring (i.e., it has remained applicable over time and will continue to apply in ...
Levenson, Steven A
core  

Decision Making with Inaccurate, Unreliable Data

, 2008
This article reviews some evidence that decision makers often rely on inaccurate or unreliable data. The article also points out ways decision makers react when they realize their data are inaccurate or unreliable.
Hodgkinson, Gerard P, Mezias, John M, Starbuck, William H   +2 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Decision making [PDF]

Current Biology, 2005
openaire   +2 more sources

Patient readiness for shared decision making about treatment: Conceptualisation and development of the ReadySDM

Health Expectations
Introduction Shared decision making (SDM) requires an active role of both clinicians and patients. We aimed to conceptualise patient readiness for SDM about treatment, and to develop a patient questionnaire to assess readiness.
Sascha M. Keij, Anne M. Stiggelbout, Arwen H. Pieterse   +2 more
doaj   +1 more source

Intuition in Organisational Decision-Making

, 2020
The Oxford Handbook of Organizational Decision-Making comprehensively surveys research on organizational decision-making, broadly ...
Sadler-Smith, E, Sparrow, PR
core  

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Visualizing A Discrete-Event-Simulation Model-The Application Of Alternative Methods For A Breast Cancer Decision- Analytic Model

, 2014
Purpose: Discrete event simulation (DES) is a commonly used modeling method to analyze the comparative effectiveness of alternative health technologies and to optimize resource alloca- tion in health care settings.
Jahn, Beate, Kluibenschädl, Martina, Popper, Nikolas, Siebert, Uwe, Rochau, Ursula, Shterjovska, Jasmina, Kurzthaler, Christina, Einzinger, Patrick, Piringer, H., Urach, Christoph   +9 more
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