Results 251 to 260 of about 7,088,536 (331)

The challenges, opportunities, and lessons learned in evidence-informed decision making in Africa

, 2016
International Food Policy Research Institute, https://orcid.org/0000-0002-2793-8985 Verstraeten, Roosmarijn   +1 more
openalex   +2 more sources

Distributed cognition in collective environmental decision-making [PDF]

, 2010
Wong, James
core  

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Efforts towards the institutionalisation of evidence-informed decision-making. [PDF]

BMJ Evid Based Med
Boeira L, Hayter E, Oliver S, Mahlanza-Langer L, Simeon D, Bangpan M, Osorio Calderon V, Reveiz L, Hunte SA, Bogale Wolde F, Kuchenmuller T.   +10 more
europepmc   +1 more source

Associative Relevance Based Eye Fixations Enhance Decision Making Processes in Scene Perception

, 2016
Gufran Ahmad
openalex   +2 more sources

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source

Right frontopolar cortex stimulation and its role in alternative strategy use in decision-making: a tDCS study

Brain Stimulation
Andrey Timashkov, Oksana Zinchenko, Vasily Klucharev   +2 more
doaj   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Influence of Intraocular Pressure on Clinical Decision-Making in Glaucoma Management.

JAMA Ophthalmol
Polski A, Brintz BJ, Hess R, Kawamoto K, Medeiros FA, Stein JD, Stagg BC, SOURCE Consortium.   +7 more
europepmc   +1 more source