Results 151 to 160 of about 12,247,022 (294)

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Governance frameworks and decision-making models for intensive care units in low- and middle-income countries: a scoping review protocol. [PDF]

BMJ Open
Ghoshal A, Damani A, Rao S, Varghese V C, Salins N.   +4 more
europepmc   +1 more source

Analyzing dynamic decision-making models using Chapman-Kolmogorov equations. [PDF]

J Comput Neurosci, 2019
Barendregt NW, Josić K, Kilpatrick ZP.
europepmc   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Geostatistical and multi-criteria decision-making models to subsidize a quantitative monitoring network of aquifers intensively used for irrigated agriculture: the case of Urucuia Aquifer System, Brazil. [PDF]

Environ Monit Assess
Leão BRC, da Silva Junior GC, Marques EAG.   +2 more
europepmc   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Comparing intertemporal decision-making models: Predictions and applications in lifespan through subjective time perception. [PDF]

Br J Psychol
Dai L, Wang Y, Chark R, Liu L.
europepmc   +1 more source

The use of multi-criteria decision making models in evaluating anesthesia method options in circumcision surgery. [PDF]

BMC Med Inform Decis Mak, 2017
Hancerliogullari G, Hancerliogullari KO, Koksalmis E.   +2 more
europepmc   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Enhancing teacher recruitment and retention through decision-making models in education systems. [PDF]

Sci Rep
Liu T, Li W.
europepmc   +1 more source