The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Patient-reported outcomes in studies evaluating shared decision-making interventions: protocol for a systematic review and meta-analysis. [PDF]
Yoo SH, Park M, Kim MJ.
europepmc +1 more source
Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui +4 more
wiley +1 more source
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil +3 more
wiley +1 more source
Decision-Making Around Preimplantation Genetic Testing by Individuals With Neurofibromatosis Type I: A Qualitative Study. [PDF]
Ching SL +3 more
europepmc +1 more source
Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source
An Exploratory Study of Physician Decision-Making When Treating Uncontrolled COPD
Kristin Kahle-Wrobleski,1 Bonnie KH Bui,2 Jennifer Friderici,2 Kristin J Moore,2 Maureen Carlyle,2 Noah S Webb,2 Carolyn K Martin,2 Wilson D Pace,3,4 John M Westfall3,4 1US Value Evidence and Outcomes, GSK, Philadelphia, PA, USA; 2Health Economics and ...
Kahle-Wrobleski K +8 more
doaj
Psychometric Properties of the General Decision-Making Style (GDMS-20) Questionnaire in a Lebanese Arab Adult Sample. [PDF]
Rahme R +10 more
europepmc +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
The relationship between smartphone distraction and clinical decision-making among nurses. [PDF]
Bekar P, Çalık SA, Efe E.
europepmc +1 more source

