Results 231 to 240 of about 1,481,839 (312)

Mixed methods evaluation of a clinical decision support system to reduce variation in healthcare. [PDF]

NPJ Digit Med
Pak A, Robertson ST, Nguyen BH, Hodgson T, Sullivan C, Burton-Jones A.   +5 more
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

MOCRA: A multi-algorithm clinical decision support system for the early detection of ovarian cancer. [PDF]

J Ovarian Res
Safaie A, Ghaffari P, Ghaderzadeh M, Salehnasab C.   +3 more
europepmc   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Acceptability, Usability, and Perceived Quality of Care of a Digital Decision Support System in Tele-Primary Health Care in Sindh, Pakistan: Sequential Explanatory Mixed Methods Pilot Study. [PDF]

JMIR Form Res
Jawed S, Tahir HN, Shaikh A, Aziz H, Khurram SS, Aga IZ, Muzzamil M, Karim M, Kazi AM, Habib SS.   +9 more
europepmc   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Development and Evaluation of the Personal Patient Profile-Bladder Cancer (P3-BC): A Web-Based Decision Support System for Patients Considering Cystectomy and Urinary Diversion. [PDF]

Cancers (Basel)
Mohamed NE, Berry DL, McReynolds J, Korn T, Kata H, Benn E, Scharp D, Sfakianos J, Mehrazin R, Wiklund P, Lober WB.   +10 more
europepmc   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Monitoring prostate cancer under androgen-deprivation therapy: insights from the implementation of a clinical decision support system dashboard. [PDF]

Front Oncol
Martínez-Pérez Á, Collantes G, Ruiz-Cerdá JL, Conde-Moreno A, Gironés R, Garcillán B, Amengual J, Gas ME.   +7 more
europepmc   +1 more source