Results 71 to 80 of about 20,607 (261)

Ciclopirox Olamine Inhibits the NLRP3 Inflammasome to Alleviate Inflammatory Diseases

Advanced Science, EarlyView.
There is no drug targeting the NLRP3 inflammasome that has been approved for use in clinical settings. Ciclopirox olamine (CPX), an antifungal agent approved by the US Food and Drug Administration (FDA), is identified as a specific and potent NLRP3 inflammasome inhibitor. CPX targets the NACHT domain of NLRP3 at Y381 to impair NLRP3 oligomerization and
Xinyu Xia, Hui You, Ke Zhang, Hui Jiang, Hongping Liu, Lianghua Liu, Aijie Zhang, You Zhou   +7 more
wiley   +1 more source

Coalition decision support system designing

Vestnik Samarskogo Gosudarstvennogo Tehničeskogo Universiteta. Seriâ: Fiziko-Matematičeskie Nauki, 2013
We describe the main stages of designing and development of the coalition decision support system (DSS). The article includes the requirements to the model, the model description in the form of tuple structures, algorithm of multi-agent simulation, the ...
Alexey S Zraenko, Vladimir P Fedotov, Konstantin A Aksenov   +2 more
doaj   +3 more sources

SSR4 sustains Tertiary Lymphoid Structures by Regulation Quality Control of N‐linked Glycosylation During B‐cell Differentiation Into Plasmacyte in Colorectal Cancer

Advanced Science, EarlyView.
SSR4, a TRAP component induced in B cells, governs BAFFR N‐glycosylation via DDOST to sustain NF‐κB signaling, B‐cell differentiation, and TLS maturation. Its loss impairs anti‐tumor immunity, while overexpression improves antibody glycosylation and ADCC, revealing a critical regulator for cancer immunotherapy.
Wei Zhao, Youcai Zhao, Haiyang Li, Bowen Yang, Siyan Lu, Xueting Fu, Caixia Zhang, Yirong Chen, Xiaofeng Bian, Xinghua Ma, Xiaobing Yang, Bin Wang, Yuan Fang, Lulu Yang, Yelin Zhao, Shuli Zhao   +15 more
wiley   +1 more source

O Processo Decisório Descrito pelo Indivíduo e Representado nos Sistemas de Apoio à Decisão [PDF]

RAC: Revista de Administração Contemporânea, 2012
This study aimed to check if a Decision Support System (DSS) reproduces the process of human decision. Forthis, we used the fundamental elements of the Saaty’s (1991) Analytic Hierarchy Process (AHP), which allowsup to five categories of analysis ...
Eliete dos Reis, Mauri Leodir Löbler
doaj  

A Decision Support System (DSS) for the Prediction and Selection of Optimum Operational Parameters in Pressure Die-Casting Processes. [PDF]

Materials (Basel), 2022
Martínez-Pastor J, Hernández-Ortega JJ, Zamora R.   +2 more
europepmc   +1 more source

Decision support system for Warfarin therapy management using Bayesian networks

, 2013
Warfarin therapy is known as a complex process because of the variation in the patients' response. Failure to deal with such variation may lead to death as a result of thrombosis or bleeding.
Yet, Barbaros,, Lifvergren, Svante, Bergman, Bo, Lifvergren, Svante,, Yet, Barbaros, Bastani, Kaveh, Marsh, William,, Bergman, Bo,, Bastani, Kaveh,, Marsh, William, Raharjo, Hendry, Raharjo, Hendry,   +11 more
core   +1 more source

De Novo Design of Membrane‐Targeting Antimicrobial Peptides Against Gram‐Negative Bacteria Using a Generative Artificial Intelligence Framework

Advanced Science, EarlyView.
Antimicrobial resistance caused by Gram‐negative bacteria remains difficult to overcome due to the protective outer membrane. To address this challenge, a multi‐condition constrained generative AI framework, GenMTAMP is proposed for de novo membrane‐targeting antimicrobial peptide design by integrating physicochemical and spatial structure descriptors.
Jingxiao Yu, Da‐Wen Sun, QingYi Wei, Yibing Zhang, Jidong Tang, Hongbin Pu   +5 more
wiley   +1 more source

Metadata-Driven DSS Framework [PDF]

Journal of the ACS Advances in Computer Science, 2008
This paper presents a proposed decision support system (DSS) framework based on extended use of metadata to include business concepts, which improves system usability, flexibility, data legibility and provides an enhanced level of integration between ...
doaj   +1 more source

A Machine Learning Decision Support System (DSS) for Neuroendocrine Tumor Patients Treated with Somatostatin Analog (SSA) Therapy. [PDF]

Diagnostics (Basel), 2021
Hasic Telalovic J, Pillozzi S, Fabbri R, Laffi A, Lavacchi D, Rossi V, Dreoni L, Spada F, Fazio N, Amedei A, Iadanza E, Antonuzzo L.   +11 more
europepmc   +1 more source

Correcting Apparent Priming Bias Unveils Fertilizer Nitrogen‐Risk Archetypes of Surplus and Depletion Across Asian Rice Systems

Advanced Science, EarlyView.
Correcting the apparent priming effect resolves systematic biases in Asian rice fertilizer nitrogen accounting. Net soil retention drops below 7%, while 48% of fertilizer escapes, inflicting US$98.53 billion in annual reactive‐nitrogen damages. High‐resolution mapping uncovers N‐risk archetypes across 42% of the rice area, delivering a spatially ...
Xiuyun Liu, Siyuan Cai, Longlong Xia, Jagdish K. Ladha, Xiaoyuan Yan, Xu Zhao   +5 more
wiley   +1 more source