Results 161 to 170 of about 595,841 (289)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Enhancing trust in clinical decision support systems: a framework for developers

BMJ Health & Care Informatics, 2021
Jeremy C Wyatt, Caroline Jones, James Thornton   +2 more
doaj   +1 more source

Artificial intelligence in radiation treatment planning: a narrative review from automation to clinical decision support. [PDF]

Transl Cancer Res
Chow JCL.
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Artificial Intelligence in Gastrointestinal Endoscopy and Hemostatic Decision-Making: Current Evidence, Clinical Implications and Implementation Barriers. [PDF]

Life (Basel)
Brusnic O, Boicean A, Ichim C, Anderco P, Onisor D.   +4 more
europepmc   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Research progress on the application of machine learning clinical decision support system in ICU

Huli yanjiu
This paper reviewed the relevant researches on the application of machine learning clinical decision support system in ICU from four aspects:overview,application status,challenges and future development trends,aiming to enhance the intelligent management
YAN Huina, LIU Ruiyun, LI Ying, DAI Jinghua, WANG Jiaxun, ZHAO Min, LU Jiayun   +6 more
doaj  

Defining physician-AI collaboration in pulmonary and critical care medicine: concepts and illustrative examples for clinical reasoning. [PDF]

ATS Sch
Vaezi A, Ashby T, Kadir S, Schweitzer M, Hadeh A, Sen P, Seeram V, Mirsaeidi M.   +7 more
europepmc   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Generative Artificial Intelligence and Large Language Models in Clinical Oncology. [PDF]

MedComm (2020)
Yu Y, Zhao Z, Wang Z, Lin R, Tan Y, Chen Y, Li T, Baptista-Hon D, Zhang X, Wu C, Tong M, Zheng L, Wu J, Monteiro O, Zhang K.   +14 more
europepmc   +1 more source