Results 121 to 130 of about 16,607,891 (208)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Strength and balance asymmetries in children and adolescents: comparison between single- and multi-sport participants

BMC Sports Science, Medicine and Rehabilitation
Background Prior research has suggested links between youth sport special-ization, inter-limb asymmetries, and injury risk, but findings remain inconsistent regarding whether single-sport athletes show greater asymmetries than their multi-sport peers ...
Bartosz Wilczyński, Jakub Buler, Rafa l Buler, Micha l Grochowski, Bartosz Puchalski, Katarzyna Zorena   +5 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Extracting legal arguments from forensic Bayesian networks [PDF]

, 2014
Recent developments in the forensic sciences have confronted the field of legal reasoning with the new challenge of reasoning under uncertainty. Forensic results come with uncertainty and are described in terms of likelihood ratios and random match ...
Sub Intelligent Systems, Hoekstra, Rinke, Prakken, Hendrik, Renooij, S., Intelligent Systems, Sub Decision Support Systems, Meyer, John-Jules Charles, Renooij, Silja, Hoekstra, R., Meyer, John-Jules Ch., Timmer, Sjoerd, Decision Support Systems, Timmer, S., Verheij, Bart, Verheij, Bart; id_orcid   +14 more
core  

Multi-Criteria Optimization of a Standalone Photovoltaic System in Cyprus (Techno-Economic Analysis)

Energies
Photovoltaic systems are increasingly recognized as one of the most advanced, efficient, and rapidly developing methods of electricity generation, utilizing the limitless potential of solar radiation while offering environmentally sustainable solutions ...
Athina Vogiatzoglou, Konstantinos Alexakis, Dimitris Askounis   +2 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Evolution of Decision Support Systems Research Field in Numbers [PDF]

The scientific production in a certain field shows, in great extent, the research interests in that field. Decision Support Systems are a particular class of information systems which are gaining more popularity in various domains.
Marius CIOCA, Florin Gheorghe FILIP, Mihai BIZOI, Ana-Maria SUDUC   +3 more
core  

Optimizing Control of Wastewater Treatment Plant With Reinforcement Learning: Technical Evaluation of Twin-Delayed Deep Deterministic Policy Gradient Agent

IEEE Access
Control of the wastewater treatment processes presents significant challenges due to the fluctuating nature of inflow and wastewater composition, alongside the system’s non-linear dynamics.
Zuzanna Klawikowska, Michal Grochowski
doaj   +1 more source