Results 111 to 120 of about 16,607,891 (208)

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Emergent Frameworks for Decision Support Systems [PDF]

Knowledge is generated and accessed from heterogeneous spaces. The recent advances in in-formation technologies provide enhanced tools for improving the efficiency of knowledge-based decision support systems.
Florin Gheorghe FILIP, Ioana Andreea STANESCU   +1 more
core  

Decision support systems for strategic information systems planning: an approach for logistics strategic management

, 2018
As business environment is getting more and more turbulent, effective strategic management and decision-making is necessary, thus the implementation of decision support systems (DSS) is considered crucial to sustain competitive advantage.
Kitsios, Fotis, Kamariotou, Maria
core   +1 more source

WOODSS - a spatial decision support system based on workflows

, 2015
Environmental planning takes advantage of geographic information systems (GIS) to manage geographic data. GIS are, however, tools which require a great deal of training and programming expertise and, furthermore, have little support for decision makers ...
Rocha, JV, Medeiros, CB, Yi, B, Seffino, LA   +3 more
core   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Bayesian networks for mastitis management on dairy farms [PDF]

, 2009
This manuscript presents the idea of providing dairy farmers with probability distributions to support decisions on mastitis management and illustrates its feasibility by two applications. Naive Bayesian networks were developed for both applications. The
Barkema, H.W., Decision Support Systems, van der Gaag, M.A., Gaag, M.A., van der, Steeneveld, Wilma, van der Gaag, Linda, Steeneveld, W., Sub Decision Support Systems begr 1/1/13, Hogeveen, H.   +8 more
core  

The Need for Standards in Evaluating the Quality of Electronic Health Records and Dental Records: A Narrative Review

Big Data and Cognitive Computing
Over the past two decades, there has been an enormous growth in the utilization of electronic health records (EHRs). However, the adoption and use of EHRs vary widely across countries, healthcare systems, and individual facilities.
Varadraj P. Gurupur, Giang Vu, Veena Mayya, Christian King   +3 more
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Innovative Business Models Towards Sustainable Energy Development: Assessing Benefits, Risks, and Optimal Approaches of Blockchain Exploitation in the Energy Transition

Energies
The goals of the European Union towards the energy transition imply profound changes in the energy field, so as to promote sustainable energy development while fostering economic growth.
Aikaterini Papapostolou, Ioanna Andreoulaki, Filippos Anagnostopoulos, Sokratis Divolis, Harris Niavis, Sokratis Vavilis, Vangelis Marinakis   +6 more
doaj   +1 more source