Results 111 to 120 of about 20,368,872 (251)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

The Need for Standards in Evaluating the Quality of Electronic Health Records and Dental Records: A Narrative Review

Big Data and Cognitive Computing
Over the past two decades, there has been an enormous growth in the utilization of electronic health records (EHRs). However, the adoption and use of EHRs vary widely across countries, healthcare systems, and individual facilities.
Varadraj P. Gurupur, Giang Vu, Veena Mayya, Christian King   +3 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Innovative Business Models Towards Sustainable Energy Development: Assessing Benefits, Risks, and Optimal Approaches of Blockchain Exploitation in the Energy Transition

Energies
The goals of the European Union towards the energy transition imply profound changes in the energy field, so as to promote sustainable energy development while fostering economic growth.
Aikaterini Papapostolou, Ioanna Andreoulaki, Filippos Anagnostopoulos, Sokratis Divolis, Harris Niavis, Sokratis Vavilis, Vangelis Marinakis   +6 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Strength and balance asymmetries in children and adolescents: comparison between single- and multi-sport participants

BMC Sports Science, Medicine and Rehabilitation
Background Prior research has suggested links between youth sport special-ization, inter-limb asymmetries, and injury risk, but findings remain inconsistent regarding whether single-sport athletes show greater asymmetries than their multi-sport peers ...
Bartosz Wilczyński, Jakub Buler, Rafa l Buler, Micha l Grochowski, Bartosz Puchalski, Katarzyna Zorena   +5 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Multi-Criteria Optimization of a Standalone Photovoltaic System in Cyprus (Techno-Economic Analysis)

Energies
Photovoltaic systems are increasingly recognized as one of the most advanced, efficient, and rapidly developing methods of electricity generation, utilizing the limitless potential of solar radiation while offering environmentally sustainable solutions ...
Athina Vogiatzoglou, Konstantinos Alexakis, Dimitris Askounis   +2 more
doaj   +1 more source