FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Indian Organised Apparel Retail Sector and DSS (Decision Support Systems) [PDF]
Indian apparel retail sector poses interesting challenges to a manager as it is evolving and closely linked to fashions. Appealing mainly to youth, the sector has typical information requirements to manage its operations.
Sharma Ankush, Vyas Preeta H
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PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
A graph neural architecture search approach for identifying bots in social media
Frontiers in Artificial IntelligenceSocial media platforms, including X, Facebook, and Instagram, host millions of daily users, giving rise to bots automated programs disseminating misinformation and ideologies with tangible real-world consequences.
Georgios Tzoumanekas +5 more
doaj +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Lightweight Embedded IoT Gateway for Smart Homes Based on an ESP32 Microcontroller
ComputersThe rapid expansion of the Internet of Things (IoT) demands scalable, efficient, and user-friendly gateway solutions that seamlessly connect resource-constrained edge devices to cloud services.
Filippos Serepas +4 more
doaj +1 more source
The Swiss Learning Health System: a national initiative supporting evidence-informed decision-making [PDF]
, 2020 Sarah Mantwill +2 more
openalex +1 more source
Information techniques for irrigation systems: Selected proceedings of the Second International Network Meeting on Information Techniques for Irrigation Systems held in Lahore/Bahawalnagar, Pakistan, 5-8 December 1994 [PDF]
Irrigation management / Irrigation systems / Decision support tools / Decision making / Information systems / Computer techniques / Models / Water management / Malaysia / Pakistan / Sri ...
Kuper, M. +3 more
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