Results 41 to 50 of about 3,913,304 (297)

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács   +8 more
wiley   +1 more source

Neural sentence embedding models for semantic similarity estimation in the biomedical domain

open access: yesBMC Bioinformatics, 2019
Background Neural network based embedding models are receiving significant attention in the field of natural language processing due to their capability to effectively capture semantic information representing words, sentences or even larger text ...
Kathrin Blagec   +3 more
doaj   +1 more source

A multi-agent system to support location based group decision making in mobile teams [PDF]

open access: yes, 2003
This paper describes an agent-based approach for developing a location-based asynchronous group decision-support system for mobile teams. The approach maximises the use of reusable service components (GSCmas — generic service component for multi-agent ...
Buckland, MA, Lee, H, Shepherdson, JW
core   +1 more source

Brainstorming Will Never Be the Same Again—A Human Group Supported by Artificial Intelligence

open access: yesMachine Learning and Knowledge Extraction, 2023
A modification of the brainstorming process by the application of artificial intelligence (AI) was proposed. Here, we describe the design of the software system “kresilnik”, which enables hybrid work between a human group and AI.
Franc Lavrič, Andrej Škraba
doaj   +1 more source

An integrated decision support environment for organisational decision making [PDF]

open access: yes, 2008
Traditional decision support systems are based on the paradigm of a single decision maker working at a stand-alone computer or terminal who has a specific decision to make with a specific goal in mind.
Boyle, Iain M.   +3 more
core  

Sirolimus for Extracranial Arteriovenous Malformations: A Scoping Review of the Evidence in Syndromic and Non‐Syndromic Cases

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson   +3 more
wiley   +1 more source

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski   +9 more
wiley   +1 more source

Asymptotic normality of recursive algorithms via martingale difference arrays [PDF]

open access: yesDiscrete Mathematics & Theoretical Computer Science, 2001
We propose martingale central limit theorems as an tool to prove asymptotic normality of the costs of certain recursive algorithms which are subjected to random input data. The recursive algorithms that we have in mind are such that if input data of size
Werner Schachinger
doaj   +1 more source

Outcomes of Live Virus Vaccination in Patients With Vascular Anomalies Being Treated With Sirolimus

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Live vaccination in patients with vascular anomalies (VA) receiving sirolimus remains controversial due to immunosuppressive effects and theoretical risks. Procedure This single‐center retrospective study included patients with VA less than 4 years old at the start of sirolimus therapy who were incompletely vaccinated.
Svatava Merkle   +5 more
wiley   +1 more source

A new structure of sociotechnical system processes using resilience engineering

open access: yesInternational Journal of Engineering Business Management, 2019
In the context of a world dominated by growing uncertainty, complex sociotechnical systems find themselves confronted with unexpected disruptions, which may lead to significant losses.
Saloua Said   +2 more
doaj   +1 more source

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