Results 61 to 70 of about 896,248 (269)

Application and Evaluation of a Blockchain-Centric Platform for Smart Badge Accreditation in Higher Education Institutions

Applied Sciences
Since its conceptualization in 2008, blockchain technology has advanced rapidly and been applied in multiple domains. In higher education, blockchain can be applied to develop ICT systems that can revolutionize student accreditation through certificate ...
Christos Kontzinos, Evangelos Karakolis, Panagiotis Kokkinakos, Stavros Skalidakis, Dimitris Askounis, John Psarras   +5 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Convolutional Autoencoders Coupled With Hypernetworks for Recognizing Attacks in 5G Networks and Beyond

IEEE Open Journal of the Communications Society
The evolution of Beyond 5G (B5G) and 6G networks requires the design of powerful deep neural networks to effectively address the emerging threats and ensure predictive, adaptive security measures that can safeguard the performance and integrity of these ...
Loukas Ilias, Stefanos Palmos, George Doukas, Afroditi Blika, George Kiokes, Christos Ntanos, Dimitris Askounis   +6 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

A Co-Creation Framework for Developing Digital Technology-Assisted Policy Adoption Roadmaps: Evidence from European Public Sector Case Studies

Applied Sciences
Public administrations increasingly seek to adopt digital tools for evidence-based policymaking, yet systematic frameworks guiding this adoption remain scarce.
Panagiotis Kokkinakos, Konstantinos Alexakis, Ourania Markaki, Ariadni Michalitsi-Psarrou, Marika Androutsopoulou, Spiros Mouzakitis, Dimitris Askounis   +6 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Explainable AI-Based Ensemble Clustering for Load Profiling and Demand Response

Energies
Smart meter data provide an in-depth perspective on household energy usage. This research leverages on such data to enhance demand response (DR) programs through a novel application of ensemble clustering.
Elissaios Sarmas, Afroditi Fragkiadaki, Vangelis Marinakis   +2 more
doaj   +1 more source