Results 71 to 80 of about 896,248 (269)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

DeepTSF: Codeless machine learning operations for time series forecasting

SoftwareX
This paper presents DeepTSF, a comprehensive machine learning operations (MLOps) framework aiming to innovate time series forecasting through workflow automation and codeless modeling. DeepTSF automates key aspects of the machine learning (ML) lifecycle,
Sotiris Pelekis, Theodosios Pountridis, Georgios Kormpakis, George Lampropoulos, Evangelos Karakolis, Spiros Mouzakitis, Dimitris Askounis   +6 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Enhanced ELECTRE III method with interval-valued hesitant fuzzy linguistic sets for multi-criteria group decision-making in smart supply networks

Applied Computer Science
This study presents a robust decision-making framework for evaluating strategic artificial intelligence (AI) initiatives within DHL's smart supply network.
Fadoua TAMTAM, Amina TOURABI
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

The Backbone of Decision Support Systems

International Journal of Information Systems for Crisis Response and Management, 2018
Understanding the current situation is critical in every natural disaster or crisis. Therefore, there is a need for accurate and up-to-date information about the scope, extent and impact of a disaster. The basis for this information is data that is available through a variety of sensors.
Hertweck, Philipp, Moßgraber, Jürgen, Kontopoulos, Efstratios, Mitzias, Panagiotis, Hellmund, Tobias, Karakostas, Anastasios, Hilbring, Désirée, van der Schaaf, Hylke, Vrochidis, Stefanos, Blume, Jan-Wilhem, Kompatsiaris, Ioannis   +10 more
openaire   +3 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Classifying Delayed Dental Care Using Machine Learning: A National Health Interview Survey Analysis

International Dental Journal
: Background: Delays in dental care worsen oral disease and mirror broader inequities in health care access and use. Objective: To estimate the 12-month prevalence of delayed dental care among US adults, to characterise disparities across demographic ...
Giang Vu, Atish Chandra, Sanket Salvi, Christian King, Varadraj Gurupur   +4 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source