Results 121 to 130 of about 580,863 (315)
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Stochastic Recurrences and their Applications to the Analysis of Partition-Valued Processes
, 2011 The thesis consists of two parts. In the first part (Chapter 1) a new technique is developed for the asymptotic analysis of the moments of linear random recurrences, and some general results are presented for the absorption times of non-increasing Markov
Sub Stochastics and Decision Theory begr +2 more
core
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Do we really need a knowledge-based decision theory? [PDF]
Synthese, 2021 Fassio D, Gao J.
europepmc +1 more source
Limit theorems for random recurrences and renewal-type processes
, 2010 Random recurrence relations are stochastic difference equations, which define recursively a sequence of random variables in such a way that each element of the sequence is a random function of preceding elements.
Sub Stochastics and Decision Theory begr +2 more
core
Decision theory with a human face
, 2017 Explores how decision-makers can manage uncertainty that varies in both kind and severity by extending and supplementing Bayesian decision ...
Bradley, Richard, Richard Bradley
core +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Optimal decision theory for diagnostic testing: Minimizing indeterminate classes with applications to saliva-based SARS-CoV-2 antibody assays. [PDF]
Math Biosci, 2022 Patrone PN +6 more
europepmc +2 more sources
Decision theory for precision therapy of breast cancer. [PDF]
Sci Rep, 2021 Kenn M +6 more
europepmc +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source