Results 121 to 130 of about 8,382,503 (310)

A quantitative decision theory of animal conflict. [PDF]

open access: yesHeliyon, 2021
Wu S   +5 more
europepmc   +1 more source

Structural and biochemical analysis of a B12 superbinder

open access: yesFEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices   +3 more
wiley   +1 more source

A cyber–physical system prospect theoretic game through a VANET lens

open access: yesIET Wireless Sensor Systems
In this paper, the problem of attack mitigation in an intelligent transportation network or vehicular network is considered as a game. The player’s perception of uncertainty and decision making is studied under a subjective prospect theoretic (PT) model ...
Ahmed A. Alabdel Abass
doaj   +1 more source

How do medical schools influence their students’ career choices? A realist evaluation

open access: yesMedical Education Online
Introduction The career choices of medical graduates vary widely between medical schools in the UK and elsewhere and are generally not well matched with societal needs.
Adam Thomas   +4 more
doaj   +1 more source

Decision Theory versus Conventional Statistics for Personalized Therapy of Breast Cancer. [PDF]

open access: yesJ Pers Med, 2022
Kenn M   +5 more
europepmc   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

The Bernoulli sieve: an overview [PDF]

open access: yes, 2010
The Bernoulli sieve is a version of the classical balls-in-boxes occupancy scheme, in which random frequencies of infinitely many boxes are produced by a multiplicative random walk, also known as the residual allocation model or stick-breaking.
Sub Stochastics and Decision Theory begr   +4 more
core  

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

open access: yesFEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge   +6 more
wiley   +1 more source

A harm-threshold model for ethical organ allocation

open access: yesFrontiers in Health Services
BackgroundAllocation of scarce donor organs must balance improving overall outcomes with protecting patients at greatest near-term risk. Urgency-focused systems such as MELD (Model for End-Stage Liver Disease) are efficient in saving lives but can reduce
Yan Jun Lin
doaj   +1 more source

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