Results 131 to 140 of about 8,382,503 (310)

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Optimal decision theory for diagnostic testing: Minimizing indeterminate classes with applications to saliva-based SARS-CoV-2 antibody assays. [PDF]

Math Biosci, 2022
Patrone PN, Bedekar P, Pisanic N, Manabe YC, Thomas DL, Heaney CD, Kearsley AJ.   +6 more
europepmc   +2 more sources

Decision making, symmetry and structure: Justifying causal interventions

Journal of Causal Inference
We can use structural causal models (SCMs) to help us evaluate the consequences of actions given data. SCMs identify actions with structural interventions. A careful decision maker may wonder whether this identification is justified.
Johnston David O., Ong Cheng Soon, Williamson Robert C.   +2 more
doaj   +1 more source

Decision theory for precision therapy of breast cancer. [PDF]

Sci Rep, 2021
Kenn M, Cacsire Castillo-Tong D, Singer CF, Karch R, Cibena M, Koelbl H, Schreiner W.   +6 more
europepmc   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

The decision paradoxes motivating Prospect Theory : The prevalence of the paradoxes increases with numerical ability

, 2019
Prospect Theory (PT: Kahneman & Tversky, 1979) of risky decision making is based on psychological phenomena (paradoxes) that motivate assumptions about how people react to gains and losses, and how they weight outcomes with probabilities.
Nilsson, Håkan, Juslin, Peter, Millroth, Philip   +2 more
core   +2 more sources

Gazing at Social Interactions Between Foraging and Decision Theory. [PDF]

Front Neurorobot, 2021
D'Amelio A, Boccignone G.
europepmc   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Algorithmic Decision Theory for solving complex decision problems [PDF]

, 2017
Today's decision makers in fields ranging from engineering to psychology, from medicine to economics and/or homeland security are faced with remarkable new technologies, huge amounts of information to help them in reaching good decisions, and the ability
BISDORFF, Raymond
core   +1 more source