Results 91 to 100 of about 6,176,379 (373)
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Decision tree analysis for prostate cancer prediction [PDF]
Srpski Arhiv za Celokupno Lekarstvo, 2019 Introduction/Objective. The use of serum prostate-specific antigen (PSA) test has dramatically increased the number of men undergoing prostate biopsy. However, the best possible strategies for selecting appropriate patients for prostate biopsy have yet ...
Stojadinović Miroslav M. +2 more
doaj +1 more source
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
MAPTree: Beating “Optimal” Decision Trees with Bayesian Decision Trees
Proceedings of the AAAI Conference on Artificial IntelligenceDecision trees remain one of the most popular machine learning models today, largely due to their out-of-the-box performance and interpretability. In this work, we present a Bayesian approach to decision tree induction via maximum a posteriori inference of a posterior distribution over trees.
Sullivan, Colin +2 more
openaire +2 more sources
Screening for lung cancer: A systematic review of overdiagnosis and its implications
Molecular Oncology, EarlyView.Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
A Chi-MIC Based Adaptive Multi-Branch Decision Tree
IEEE Access, 2021 Since the decision trees (DTs) have an advantage over “black-box” models, such as neural nets or support vector machines, in terms of comprehensibility, such that it might merit improvement for further optimization.
Jiahao Ye +6 more
doaj +1 more source
Penerapan Algoritma Decision Tree untuk Penilaian Agunan Pengajuan Kredit [PDF]
, 2015 Masih terdapat kemungkinan kesalahan penilaian agunan sebagai acuan nilai kredit, yang akan membuka peluang terjadinya NPL. Jadi diperlukan suatu cara penilaian (prediksi nilai) yang cukup proporsional, kredibel dan akurat.
Lareno, B. (Bambang), Setiadi, B. (Budi)
core
Using K-Means Cluster Analysis and Decision Trees to Highlight Significant Factors Leading to Homelessness [PDF]
, 2021 Andrea Yoder Clark +5 more
openalex +1 more source
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source