Results 71 to 80 of about 305,651 (314)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Rockburst prediction in kimberlite using decision tree with incomplete data

Journal of Sustainable Mining, 2018
A rockburst is a common engineering geological hazard. In order to predict rockburst potential in kimberlite at an underground diamond mine, a decision tree method was employed.
Yuanyuan Pu, Derek B. Apel, Bob Lingga
doaj   +1 more source

Decision tree-based Design Defects Detection

IEEE Access, 2021
Design defects affect project quality and hinder development and maintenance. Consequently, experts need to minimize these defects in software systems. A promising approach is to apply the concepts of refactoring at higher level of abstraction based on ...
Mohamed Maddeh, Sarra Ayouni, Sultan Alyahya, Fahima Hajjej   +3 more
doaj   +1 more source

Multiple decision trees

CoRR, 2013
This paper describes experiments, on two domains, to investigate the effect of averaging over predictions of multiple decision trees, instead of using a single tree. Other authors have pointed out theoretical and commonsense reasons for preferring the multiple tree approach.
Suk Wah Kwok, Chris Carter
openaire   +2 more sources

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Exploiting a knowledge base for intelligent decision tree construction to enhance classification power

Engineering and Applied Science Research, 2022
Decision Trees are a common approach used for classifying unseen data into defined classes. The Information Gain is usually applied as splitting criteria in the node selection process for constructing the decision tree.
Sirichanya Chanmee, Kraisak Kesorn
doaj  

Predicting Disease-Specific Survival for Patients With Primary Cholangiocarcinoma Undergoing Curative Resection by Using a Decision Tree Model

Frontiers in Oncology, 2022
BackgroundThe aim of this study was to derive and validate a decision tree model to predict disease-specific survival after curative resection for primary cholangiocarcinoma (CCA).MethodTwenty-one clinical characteristics were collected from 482 patients
Bing Quan, Bing Quan, Miao Li, Miao Li, Shenxin Lu, Shenxin Lu, Jinghuan Li, Jinghuan Li, Wenfeng Liu, Wenfeng Liu, Feng Zhang, Feng Zhang, Rongxin Chen, Rongxin Chen, Zhenggang Ren, Zhenggang Ren, Xin Yin, Xin Yin   +17 more
doaj   +1 more source

Causal Decision Trees [PDF]

IEEE Transactions on Knowledge and Data Engineering, 2017
Uncovering causal relationships in data is a major objective of data analytics. Causal relationships are normally discovered with designed experiments, e.g. randomised controlled trials, which, however are expensive or infeasible to be conducted in many cases.
Jiuyong Li, Saisai Ma, Thuc Duy Le, Lin Liu 0003, Jixue Liu   +4 more
openaire   +2 more sources

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Decision tree analysis for prostate cancer prediction [PDF]

Srpski Arhiv za Celokupno Lekarstvo, 2019
Introduction/Objective. The use of serum prostate-specific antigen (PSA) test has dramatically increased the number of men undergoing prostate biopsy. However, the best possible strategies for selecting appropriate patients for prostate biopsy have yet ...
Stojadinović Miroslav M., Stojadinović Milorad M., Pantić Damjan N.   +2 more
doaj   +1 more source